[underwater]

I have always felt significantly better when I have had a large fruit salad made by my wife.

What if it were made by someone else? []

(sorry, couldn't resist).

One has to really pois before committing to such culinary risktaking.

[demografx]

...do you realize other people have sex all the time and don't have side effects like we do?

My guess is that about 99%+ do.

[demografx]

...the only reported cure for POIS in this forum...

Underwater, did you see B_Jim's list of cured/healed in the forum?
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

[demografx]

I have always felt significantly better when I have had a large fruit salad made by my wife.

What if it were made by someone else? []

(sorry, couldn't resist).

One has to really pois before committing to such culinary risktaking.

Touché  [] []

[demografx]

sex was fine until I started drinking coffee I believe.

Fascinating for me, because i would love to explain mine that way. Nice and simple! But if this were universally true, POIS would be rampant, which it's not.

[demografx]

Ever since sleeping on my side, I don't get NEs.  Occationally I'll roll on my back or chest unintentionally while sleeping and an NE will happen.

Limejuice, I hope this can work for others, too!

[GoingCrazy]

I dunno what theories i can have for the cause, i support the auto-immune one though, it kind of make sense.  Our heads are overloaded with hormones and maybe our body views that as a threat, maybe that is why i get immense headaches.... our bodies recognize the hormones as "foreigners" and then treats it like an infection.  I also find it weird the last time i had pois I was sneezing and "yellow" mucus was coming out of my nose, indicating an infection

[martin88]

The theory that I have about POIS, is that the symptoms may be caused by a deficiency of one or more of the catecholamines of which noradrenaline may be the most relevant.

Deloun, I believe in this theory about noradrenaline (or norepinephrine). I thought exactly the same thing and wanted to post about this, but the fact that some people tried SNRI without success made me think that perhaps it's not true.

I have slightly this symptom you mention about genitals when in pois. Running, working, taking chocolate or coffee help (before the side effects for these foods). The symptom is mentionned in this page for the first remedy : http://www.hpathy.com/diseases/spermatorrhoea-symptoms-treatment-cure.asp

Also I know that coffee is increasing noradrenaline, so maybe before taking it NA is continuously low and after we take coffee the complete depletion occurs because we can't produce enough NA.

In a book I have it's written that sympathetic nerves exhaustion is causing pois, and I think these nerves are releasing noradrenaline.
http://en.wikipedia.org/wiki/Sympathetic_nervous_system

http://en.wikipedia.org/wiki/Noradrenaline


My MD also thinks I have a problem with noradrenaline because he wants me to take clomipramine or an equivalent.

Noradrenaline is highly involved in motivation and concentration.

I think the herb rhodiola is supposed to increase noradrenaline but for me it causes a complete insomnia, perhaps a sign that something is depleted.

[Finally]

here is some information I found on adrenals:

http//www.patientsmedical.com/adrenals.html

[underwater]

Catecholamines: A flow of consciousness rant---Signifying nothing or something???Read only at your leisure------------------------------------------------------------
For me, it is very logical to look at Catecholamines in trying to figure out the POIS riddle, because my POIS and GAD (flareups) share identical symptoms. Why haven't I solved POIS, when in the past I have solved GAD on and off? Good question!
Until this forum, I have not focused on the adrenal glands. I always thought about my brain. Girlwind seems to have influenced me in focusing on adrenal rehabilitation. That type of nutritional therapy involves considering adrenal fatigue. I might have made the mistake of always thinking I constantly had too much norepinephrine and epinephrine. Instead, the last few hours it dawned on me that I may be deficient in norepinephrine. Also, I have been noticing something weird lately. I sometimes go into the water fatigued and after a few laps feel just depleted. I fight not to get out. Then, after 15 minutes, I get some kind of rush, and I'm energetic. Could my enhanced metabolism be working with my new supplements to make some more norepinephrine/epinephrine? Could my frequent insomnia and lousy sleep be due to slow metabolism and reduced production of norepinephrine etc.? Could there be general metabolic shutdown in some of us after orgasm, thus causing failure of adrenals to produce what they're supposed to produce? What is metabolic shutdown? I don't know. I just coined this in my flow of consciousness post. However, could it be that the caloric expenditure is so overwhelming that the body refuses to reup for a few days. It's not going to "burn", it's going to not even rest. It's just quitting for a while.
What do epinephrine and nor do? Nothing!!! All the hormones and neurotransmitters in our body are thrown out of whack. So why do they come back? Why do we recover? Maybe goingcrazy is right; our brain (pituitary, hypo) sense trouble down there, and they desperately signal the conversion of other neurotransmitters (dopamine for example) to go and help the adrenals.

[martin88]

This is interesting (if you didn't visit the wiki link about noradrenaline) : 

Biosynthesis :
Norepinephrine is synthesized by a series of enzymatic steps in the adrenal medulla from the amino acid tyrosine:

The first reaction is the oxidation into dihydroxyphenylalanine (L-DOPA) (DOPA = 3,4-DiHydroxy-L-Phenylalanine), catalyzed by tyrosine hydroxylase. This is the rate-limiting step.
This is followed by decarboxylation into the neurotransmitter dopamine, catalyzed by pyridoxal phosphate & DOPA decarboxylase.
Last is the final β-oxidation into norepinephrine by dopamine beta hydroxylase, requiring ascorbate as a cofactor (electron donor).

(If prolactin is increased, dopamine is decreased so the noradrenaline chain is broken.)

Norepinephrine, along with dopamine, has come to be recognized as playing a large role in attention and focus. For people with ADD/ADHD, psychostimulant medications such as methylphenidate (Ritalin/Concerta), dextroamphetamine (Dexedrine), and Adderall (a mixture of dextroamphetamine and racemic amphetamine salts) are prescribed to help increase levels of norepinephrine and dopamine.

[CertainlyPOIS]

Am with the dopamine, nonphenerine  /prolactin theory, because i have a two day high where i believe i have an overdose of dopamine or other neurochemicals that tame prolactin.  And because prolactin and dopamine are involved in a form of system where one determines the amount of the other. 

[GoingCrazy]

What I'm thinking is.  A lot of people with depression might actually have pois, you know?  I thought I had depression for about 2 years until I found out it was from the sex.  I was even prescribed lexapro, an antidepressant

And it's interesting I have an uncle who is depressed... maybe we have identical genes and he just hasn't figured out it is from sex

I dunno guys, it is ok to feel like crap once and a while, but everyday if you have sex... that''s just impossible to deal with... people around me think I'm a different person [:-'(]

[demografx]

what do you mean by there will be others

Besides SSTAR, there are other "influentials" who can spread the good word about this forum. For example, I also wrote to the psychiatrist who wrote the NY Times article (alas, he didn't respond...but there will be...others!)

[demografx]

- Sceletium Tortuosum helps reducing POIS symptoms. It's a herb of which the main active alkaloid is mesembrine, which is a PDE4 inhibitor with a mechanism in a way similar to rolipram (11) that raises levels of noradrenaline.

Deloun, do you know if there's a relationship between your noradrenaline theory and PDE-5 inhibitors like Levitra? And with testosterone?

[demografx]

to be sure of the abstinence thing, I'm not going to have sex at all for a year and then do it and see what happens

what about NE's?

[GoingCrazy]

to be sure of the abstinence thing, I'm not going to have sex at all for a year and then do it and see what happens

what about NE's?

Lol i'll have to "lay on my side"

[demografx]

Deloun, I believe in this theory about noradrenaline (or norepinephrine). I thought exactly the same thing and wanted to post about this, but the fact that some people tried SNRI without success made me think that perhaps it's not true.

Martin, maybe your theory is still possibly correct. Effexor (SNRI) didn't work for me but maybe SNRI's just aren't powerful enough for norepinephrine balancing?

[demografx]

Why do we recover?

That question stumped me the most!!

[demografx]

to be sure of the abstinence thing, I'm not going to have sex at all for a year and then do it and see what happens

what about NE's?

Lol i'll have to "lay on my side"

For a year?? []