[demografx]

Limejuice, would you mind just elaborating a teensy bit more on discipline and POIS? For example, in spite of POIS, did you work through the day rather than call in sick?

[demografx]

Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasure
http://www.scientificamerican.com/article.cfm?id=the-orgasmic-mind

[demografx]

I just want to post something I think about and am thankful for that goes against the grain of this thread but should be acknowldged.  POIS has given something to me that's made me absolutely a better person and that is dicipline.  Straight faced, no blinking, up most honesty - dealing with POIS has straigthened my self control and character.

 I think it should be said for myself.

Not me. It has driven me absolutely mad before and led to a lot of self destructive behavior earlier on in my life, mostly out of frustration with its existence and girlfriend's DISBELIEF in its existence. It took 15 years before my sanity was once again in control, and I only managed that through absolute abstinence.

Defsync, it's an absolute killer. I don't know how I made it thru 30+ years!!

[demografx]

okay so one thing i've been poking around is histamine.

http://en.wikipedia.org/wiki/Histamine_H3_receptor

"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."

now about histamine itself:

http://en.wikipedia.org/wiki/Histamine

"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."

Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms.

Histadelia: This is a disorder, prominent in males, of too
much histamine in the blood.

Symptoms include hyperactivity, compulsions, obsessions, inner
tensions, blank mind episodes, phobias, chronic depression,
and strong suicidal tendencies.

Physical signs can include little tolerance for pain, rapid
metabolism, lean build, profuse sweating, seasonal allergies,
and frequent colds.

So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.

Just another random theory i have....

Defsync, you wrote, “after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop when I feel POIS strongly…after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.”

Very interesting. When I’m in-POIS, the feeling I’ve had very often is as if I were somehow injected with some POISonous (no pun intended)  substance. And I can feel the poison coursing through my veins.  Imagination? Who knows…

At the onset of POIS, my nose gets stuffed, so I take Afrin, which is a decongestant and not an antihistamine, so I’m not sure whether or not that supports the Histamine theory.

Not Histamine-related, but POIS-related: My “dried up” fingertips continue to drive me berserk, even with my treatment and dramatic improvement.  Day Zero is still not much fun.

[Counterpoints]

Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasure
http://www.scientificamerican.com/article.cfm?id=the-orgasmic-mind

Sure, add it if you like, as an external reference.  I am not sure how it fits specifically with POIS though.

[Counterpoints]

man am i glad to see you guys still going strong... too bad the wiki page got cut down to size, since it's said you cant use a forum as a source of reference =( but at least the page is still up

okay so one thing i've been poking around is histamine.

http://en.wikipedia.org/wiki/Histamine_H3_receptor

"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."

now about histamine itself:

http://en.wikipedia.org/wiki/Histamine

"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."

Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms.

Histadelia: This is a disorder, prominent in males, of too
much histamine in the blood.

Symptoms include hyperactivity, compulsions, obsessions, inner
tensions, blank mind episodes, phobias, chronic depression,
and strong suicidal tendencies.

Physical signs can include little tolerance for pain, rapid
metabolism, lean build, profuse sweating, seasonal allergies,
and frequent colds.

So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.

Just another random theory i have....

You could try taking an antihistamine?

[demografx]

Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasure
http://www.scientificamerican.com/article.cfm?id=the-orgasmic-mind

Sure, add it if you like, as an external reference.  I am not sure how it fits specifically with POIS though.

Right, that's why I wanted you to see it. I don't want to lessen credibility. The main plus is the idea of showing scientific acceptance of studying ORGASM, the science which is in it's infancy. I'll put it there, but feel free to remove it if you feel it's not a strong enough connection to POIS.

I also have a question about POIS defined as "hours or days". It says elsewhere in wikipedia "needs days of rest". I wonder if only "days" would be more accurate than "hours/days". Marnia and the New York Times article talk about "hours" as a fairly widespread, universal, mild orgasmic aftereffect, unrelated to the dark severity of POIS, which lasts "forever", i.e., days or even weeks.

[demografx]

TECH PROBLEMS

Is anyone else having problems with writing long posts or Private Messages?

When the writing gets to a certain length, the preview box that we write in "snaps back" on me and I can't see what I'm typing. So the only way around this is to copy and paste into Word, then copy and paste back to the POIS thread.

I've been complaining about this to Naked Science Forum people.

If you have the same problem with long posts/PM's, please PM me about it, or post about it here.

THANKS!

[Counterpoints]

Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasure
http://www.scientificamerican.com/article.cfm?id=the-orgasmic-mind

Sure, add it if you like, as an external reference.  I am not sure how it fits specifically with POIS though.

Right, that's why I wanted you to see it. I don't want to lessen credibility. The main plus is the idea of showing scientific acceptance of studying ORGASM, the science which is in it's infancy. I'll put it there, but feel free to remove it if you feel it's not a strong enough connection to POIS.

I also have a question about POIS defined as "hours or days". It says elsewhere in wikipedia "needs days of rest". I wonder if only "days" would be more accurate than "hours/days". Marnia and the New York Times article talk about "hours" as a fairly widespread, universal, mild orgasmic aftereffect, unrelated to the dark severity of POIS, which lasts "forever", i.e., days or even weeks.

The range seems to be from hours to days, although days is more common here.... at some point the article will need a major renovation, although we'll have to be careful about how to approach it.

[martin88]

John, so the improvement is caused by cranberries or maybe a synergic effect of both.

Cranberry has proved effects :
- antibacterial (urinary system)
- anti-inflammatory
- anti-oxydant

Wiki :" One evaluates effects of cranberry polyphenols on cytochrome P450 enzymes involved in metabolism."

Very very very interesting! Remember I have told about  cytochrome P450 when we have a look on pancreas role on steroids synthesis (cholesterol to pregnenolone).

Cytochome P450 c17 (with cytochrome p450 cc ) can convert cholesterol to pregnenolone, a steroid hormone in mitochondries.

Cranberries juice may help to increase HDL cholesterol (10?).

The problem for me is to find cranberries :/
 [] Only supplements, dehydrated fruit or juice. Very expansive ...

Thanks about HDL.
All this will increase motivation!
In case it doesn't help for POIS it will at least decrease my cardiovascular risk which is raised by low HDL.
It's good not to drink 2 liters a day because of the oxalic acid. (Bitter taste too!)

[demografx]

Sure, add it if you like, as an external reference.  I am not sure how it fits specifically with POIS though.

My previous small edits of wikipedia (nowhere near your masterful work) were straightforward enough, but just now, adding a simple reference? Stumped!

[demografx]

The range seems to be from hours to days, although days is more common here.... at some point the article will need a major renovation, although we'll have to be careful about how to approach it.

Then maybe it would be easier and also appear more consistent (for now) if we change "needs days of rest" to "needs hours or days of rest"?

[demografx]

WHO UPDATE

Pronobis, thank you! It's wonderful that you got a contact name who we can now hold accountable in this bureaucracy! As you indicated, I will send the follow up email today.

Thanks again for calling their Switzerland headquarters, and for your persistent follow-up.

[Counterpoints]

The range seems to be from hours to days, although days is more common here.... at some point the article will need a major renovation, although we'll have to be careful about how to approach it.

Then maybe it would be easier and also appear more consistent (for now) if we change "needs days of rest" to "needs hours or days of rest"?

Sure, good idea.

[nsf]

Friends.. I have been away for months now, certainly going through POIS symptoms in person. I might have missed few important findings from the forum. I would appreciate if anyone could summarize the highlight findings where we have a common consensus.

From my end, I am getting some understanding on what is happening to me post Orgasm. Typically, post Orgasm, after a brief relaxed mode, I sense I get into a physically tense state for days. This invariably happens even with me taking actions to stay relaxed. This is similar to, or same as Psychosomatic disorder (i.e., excess stress in the body). I had attempted Orgasm for continuous 5 days, during which the excess stress (Psychosomatic) had triggered an auto-immune problem. This has manifested in me, in the form of Psoriasis. I had attempted Orgasm during my Psoriasis attack. I have experienced the same Post Orgasm stress for few days, that does not impact Psoriasis attack differently (with 1 day orgasm). I did not have heart to try continuous days post Psoriasis - I would presume this might aggravate my condition.

[Pronobis]

WHO UPDATE

Pronobis, thank you! It's wonderful that you got a contact name who we can now hold accountable in this bureaucracy! As you indicated, I will send the follow up email today.

Thanks again for calling their Switzerland headquarters, and for your persistent follow-up.

Thank you too. I hope it will work

[demografx]

WHO UPDATE

Pronobis, thank you! It's wonderful that you got a contact name who we can now hold accountable in this bureaucracy! As you indicated, I will send the follow up email today.

Thanks again for calling their Switzerland headquarters, and for your persistent follow-up.

Thank you too. I hope it will work

It already has. The optimism here is increasing! []


ps - let me know the Switzerland telephone charges by PM for reimbursement.

[John21 (OP)]

nsf,

From my end, I am getting some understanding on what is happening to me post Orgasm. Typically, post Orgasm, after a brief relaxed mode, I sense I get into a physically tense state for days. This invariably happens even with me taking actions to stay relaxed. This is similar to, or same as Psychosomatic disorder (i.e., excess stress in the body). I had attempted Orgasm for continuous 5 days, during which the excess stress (Psychosomatic) had triggered an auto-immune problem. This has manifested in me, in the form of Psoriasis. I had attempted Orgasm during my Psoriasis attack. I have experienced the same Post Orgasm stress for few days, that does not impact Psoriasis attack differently (with 1 day orgasm). I did not have heart to try continuous days post Psoriasis - I would presume this might aggravate my condition.]

Why are you thinking that it is a psychosomatic disorder that caused an autoimmune problem?

[demografx]

OFF TOPIC : Humor

(We can't always be so dead serious around here! [] )

= = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =

My Urologist.....

As men age, we start seeing more of the medical world, which
nowadays seems  to include an  increasing number of women as our
physicians and therapists.  And in  my case, a new urologist...

My family doctor recently referred me to a just out of
medical school female urologist. I saw her  yesterday, and she's
absolutely drop-dead gorgeous as well as unbelievably  sexy.

She told me that I must stop masturbating.


I asked her why.
.
.
.
.
.
.
.
.
.
.
.

She said, "Because I'm trying to examine you..."

[Defsync]

man am i glad to see you guys still going strong... too bad the wiki page got cut down to size, since it's said you cant use a forum as a source of reference =( but at least the page is still up

okay so one thing i've been poking around is histamine.

http://en.wikipedia.org/wiki/Histamine_H3_receptor

"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."

now about histamine itself:

http://en.wikipedia.org/wiki/Histamine

"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."

Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms.

Histadelia: This is a disorder, prominent in males, of too
much histamine in the blood.

Symptoms include hyperactivity, compulsions, obsessions, inner
tensions, blank mind episodes, phobias, chronic depression,
and strong suicidal tendencies.

Physical signs can include little tolerance for pain, rapid
metabolism, lean build, profuse sweating, seasonal allergies,
and frequent colds.

So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.

Just another random theory i have....

You could try taking an antihistamine?

Exactly. I'm tempted to experiment with this if I can accumulate enuf days off work proceeding, though that wont be for awhile =(

Also, I just happened across a book on the intarweb that may have some good info.

http://books.google.com/books?id=7ccB3CCAtYkC&pg=PA104&lpg=PA104&dq=sleep+NMDA+receptors&source=bl&ots=JGlkc3q-6I&sig=C667SObFlnQuh2zO5mSa5Z2JAiw&hl=en&ei=kXBvSvXBM46eMcuw9OMI&sa=X&oi=book_result&ct=result&resnum=10

It notes: "Prolactin, which is elevated if its secretion is not inhibited by dopamine and other factors, is an endogenous anxiolytic neuropeptide that reduces HPA axis and oxytocin responses in males and is partly responsible for their postcoital sexual refractory period by inhibiting mesocorticolimbic DA secretion. Male CFS (chronic fatigue syndrome?)  patients often relapse after orgasm, because they often do not have enough dopamine and norepinephrine reserve to perform independent activities of daily living even prior to ejaculation, or because their catecholamine autoreceptors are hypersensitive."

hmm okay I have to do look up a couple of those terms now =P gonna see if the university library might have this book, looks rather pricey ($50+)