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Post Orgasmic Illness Syndrome (POIS)

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Offline EDS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6120 on: 20/11/2009 02:03:11 »
Quote from: Limejuice on 12/11/2009 22:12:29
I understand.

I'm reluctant to push to try T for one reason - I don't want to jeopardize my natural production of T.  If supplemented T is not the answer to POIS for me, and in testing this disrupted the natural levels for the rest of my life, I would be....upset.

With only you, Demo, cured that risk is too high for me.  If most the forum was cured with T that's a different story.


Make that two of us now! I can safely say that T treatments (5 mg patches) are helping me. I will estimate 60% because it seems to have shortened my recovery time to about half and the time I'm in POIS is less severe. As I stated almost three months ago that I would be happy to see a 5% or 10% improvement - I am seeing far better than that!

I went from 3-4 days of full blown POIS to a day or two. What is strange is that my 1st day, before T treatment, wasn't too bad; now it is my worst day, but day two is much better; which WAS my worst day. So it seems to have accelerated the time for POIS to "kick-in" and also go away. The whole nightmarish process has been moved up by a couple of days.

What does this mean? Is it just the addition of T that is causing improvement? Or is the additional T affecting some other function that speeds up the time to reach full POIS symptoms and recovery?

I don't know what is happening, of course, but I'm sure glad it is!!!!! After over 30 years of this plague, this is the first time I have tried anything that helped!! Thanks Demo!! POIS is getting cross wired... interupted... or something because it is definitely different than it has ever been after "O" for me.

Thanks to everyone involved in this forum! If we keep it up, I know we'll beat this thing!!

« Last Edit: 20/11/2009 02:16:19 by EDS »
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Offline pauliebaby61

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6121 on: 20/11/2009 02:24:27 »
Just got back from my Dr's appt. My Dr agreed with Dr in's theory about what happens to our body at O, because it IS what happens at O.
He did not think much of the products Dr Lin sells.
He did not RX SSRI's to me. He said they were not the answer and would probably have a negative effect for pois.
He felt the main culprit here is low dopamine level.He said that is the main transmitter and responsible for the good feelings we get from O. If enough isnt present, the response will be bad and exhausting.

His treatment is 3 herbal suppliments that are precursers to dopamine and seratonin. 1] 5HTP[for seratonin], 2] Mucuna[for dopamine] 3] a product high in selenium. He said he treats Parkins patients much in the same way, with good success getting rid of their tremors.

He says all 3 will increase my dopamine level. He said that the main neurotransmitter after O, which gives us a good feeling after O is dopamine.He explained that if we are low in dopamine, the bodys response to O is negative. Over time,,If we abstain, the bodys dopamine level slowly rises into the normal range, only to be depleted after the next time in the bedroom.
He felt the main cause, for me anyway, was a dopamine deficiency, and also low seratonin.
He also told me that one hit of cocaine[ i never did cocaine or any drugs] will use up the bodies supply of dopamine and it talks a full year for the dopamine level to be restored. I mention this only because it shows how important and frail this neurotransmitter is, and , just in case anyone has done this drug may explain possibly why they have pois and that quiting such drugs may reverse your symptoms over time.
My Dr feels my problem, as i described it, can be treated. But again, the proof will be in the pudding.
I will keep you posted as to how i do over time.
oh also--- my T level is now 899, which is a great number for a 48yr old male, but still does not change my pois symptoms. I am hopeful this latest treatment gives relief to me and all my fellow sufferers who read this. Hopefully i will have good things to report shortly!
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6122 on: 20/11/2009 02:26:08 »
Quote from: EDS on 20/11/2009 02:03:11
Quote from: Limejuice on 12/11/2009 22:12:29

I understand.

I'm reluctant to push to try T for one reason - I don't want to jeopardize my natural production of T.  If supplemented T is not the answer to POIS for me, and in testing this disrupted the natural levels for the rest of my life, I would be....upset.

With only you, Demo, cured that risk is too high for me.  If most the forum was cured with T that's a different story.


Make that two of us now! I can safely say that T treatments (5 mg patches) are helping me. I will estimate 60% because it seems to have shortened my recovery time to about half and the time I'm in POIS is less severe. As I stated almost three months ago that I would be happy to see a 5% or 10% improvement - I am seeing far better than that!

I went from 3-4 days of full blown POIS to a day or two. What is strange is that my 1st day, before T treatment, wasn't too bad; now it is my worst day, but day two is much better; which WAS my worst day. So it seems to have accelerated the time for POIS to "kick-in" and also go away. The whole nightmarish process has been moved up by a couple of days.

What does this mean? Is it just the addition of T that is causing improvement? Or is the additional T affecting some other function that speeds up the time to reach full POIS symptoms and recovery?

I don't know what is happening, of course, but I'm sure glad it is!!!!! After over 30 years of this plague, this is the first time I have tried anything that helped!! Thanks Demo!! POIS is getting cross wired... interupted... or something because it is definitely different than it has ever been after "O" for me.

Thanks to everyone involved in this forum! If we keep it up, I know we'll beat this thing!!




Wow, EDS, I'm thrilled for you!!!

My thoughts about it are exactly like yours! I would add that it feels like "rapid sperm replenishment" is the reason why equilibrium comes back so much faster.

Thanks so much for sharing your success with the group.
« Last Edit: 20/11/2009 02:28:12 by demografx »
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6123 on: 20/11/2009 02:34:52 »
Quote from: pauliebaby61 on 20/11/2009 02:24:27

I am hopeful this latest treatment gives relief to me and all my fellow sufferers who read this. Hopefully i will have good things to report shortly!


I don't understand the basis, but if it provides POIS relief, I wish you the absolute best!

Here are some previous experiences posted here with 5HTP:
http://www.google.com/search?hl=en&q=5HTP+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&oq=&aqi=

Can you please share with us what your doc's background or qualifications are in claiming to understand the relationships between orgasm, serotonin and dopamine...and his recommendations to you?

Or do you just generally trust his judgement?
« Last Edit: 20/11/2009 03:11:16 by demografx »
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6124 on: 20/11/2009 03:07:14 »

Article on Dopamine and Orgasm:
http://scienceblogs.com/cortex/2008/02/dopamine_and_orgasm.php

And one more: from The Science of Orgasm:
http://www.thepsychologist.org.uk/archive/archive_home.cfm?volumeID=21&editionID=157&ArticleID=1303

pauliebaby, thanks for re-opening the ongoing orgasm-dopamine-serotonin discussions we've had here since the beginning!

« Last Edit: 20/11/2009 03:09:37 by demografx »
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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6125 on: 20/11/2009 06:14:41 »
I went to the doctor Wednesday and told him about what I have.  He said this is basically post-coital cephalgia, or headaches.  I told him how I wake up in the morning with fog and that it causes extreme anxiety when I do it.  He told me that hes seen a lot of patients with orgasmic headaches, and that my symptoms could just have to do with blood vessel constriction.  I've been doing breathing exercises the past couple of days now and I do notice a difference.  I did "O" last night, and last weekend, with no POIS except extreme tiredness after "O", no anxiety what-so-ever.  I doubt if POIS could just be a symptom of blood vessel constriction but still we do not know what the true cause is.  He is having me sent back this coming Tuesday to examine my "circle of willis", which is a cluster of blood vessels that supply the brain.
« Last Edit: 22/11/2009 00:03:02 by demografx »
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Offline RhythmSpring

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6126 on: 20/11/2009 06:50:49 »
Quote from: goingcrazy on 20/11/2009 06:14:41
I went to the doctor Wednesday and told him about what I have.  He said this is basically post-coital cephalgia, or headaches.  I told him how I wake up in the morning with fog and that it causes extreme anxiety when I do it.  He told me that hes seen a lot of patients with orgasmic headaches, and that my symptoms could just have to do with blood vessel constriction.  I've been doing breathing exercises the past couple of days now and I do notice a difference.  I did "O" last night, and last weekend, with no POIS except extreme tiredness after "O", no anxiety what-so-ever.  I doubt if POIS could just be a symptom of blood vessel constriction but still we do not know what the true cause is.  He is having me sent back this coming Tuesday to examine my "circle of willis", which is a cluster of blood vessels that supply the brain.


This is connected to a post I made a while back: I have another theory! It may seem hokey, like in the category with the chi theory, but don't you dare shoot it down 'til you've tried it.

I'll be simple and quick. I notice when I'm O'ing I tense my abdominal muscles. I also notice I'm tensing my abdominal muscles when I'm experiencing social anxiety and gastrointestinal difficulty.

So try, next time you O, do not constrict any abdominal muscles throughout the whole thing. Make it a note to leave those muscles relaxed in the minutes, hours then days after O'ing.

It doesn't have to make sense in your mind to work in your body. Just try it.

-----

This is done by breathing deeply, expanding the abdomen. The key word is RELAX, RELAX RELAX. There are no problems. Just relax into, breathe deeply and don't tense up.
« Last Edit: 22/11/2009 00:08:16 by demografx »
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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6127 on: 20/11/2009 07:34:02 »
Quote from: demografx on 19/11/2009 22:53:37

Z_one, the outreach letter I PM'd you includes an attachment of Dr Waldinger's POIS study. If you want it, The only way I can send you the PDF is via your regular email address, which you can PM to me. If you do, please use "AT" instead of "@", this system intermittently rejects "@".

Thanks again!

Thx Demo....I'll check it out and get back to you....
« Last Edit: 20/11/2009 07:37:31 by Z_one »
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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6128 on: 20/11/2009 07:48:22 »
Quote from: B_Jim on 20/11/2009 06:53:09
Quote from: demografx on 19/11/2009 20:08:11

Can anyone explain the difference between endorphins and dopamine? They're both internally generated "feel good" chemicals and almost seem to be the same as I've heard them described.



Endorphins are natural part of the family of opiates such as heroin and morphine.

Look :
http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_heroine.html#drogues
(thanks Martin for link)

The basic theory is :
-more endorphins/opiates inhibits Gaba release.
- less Gaba means less downregulation of dopamine.
- So there is more dopamine secreted.

The point I don't understand is how can opiates have anti-anxety and analgesic effect if they cause a reduction of Gaba.  [???] Can someone explain ?

---

After, we can expect :
- a dopamine/catecholamine depletion
- the opiate withdrawal syndrome .



According to Wikepedia..

Opiates inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released...

I think since endorphins are anti-anxiety and pain killers them selves...therefore Gaba is not needed since the presence of Gaba will inhibit the secretion of Dopamine,,,,,

Gaba is believed to be the brakes of the brain,....its presence inhibits the secretion of brain neurotransmitters when they are not needed.....

Hope this helps.....
« Last Edit: 20/11/2009 17:04:59 by Z_one »
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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6129 on: 20/11/2009 11:50:27 »
Quote from: goingcrazy on 20/11/2009 06:14:41
I went to the doctor Wednesday and told him about what I have.  He said this is basically post-coital cephalgia, or headaches.  I told him how I wake up in the morning with fog and that it causes extreme anxiety when I do it.  He told me that hes seen a lot of patients with orgasmic headaches, and that my symptoms could just have to do with blood vessel constriction.  I've been doing breathing exercises the past couple of days now and I do notice a difference.  I did "O" last night, and last weekend, with no POIS except extreme tiredness after "O", no anxiety what-so-ever.  I doubt if POIS could just be a symptom of blood vessel constriction but still we do not know what the true cause is.  He is having me sent back this coming Tuesday to examine my "circle of willis", which is a cluster of blood vessels that supply the brain.

I'm not bothered by headaches in POIS, if I have one, but it's interesting for POIS who have this.
What you experience with breathing is normal.
I suggest to avoid this quick breathe or you'll hyperventilate. It happened to me after I had breathing difficulties caused by a stomach problem and it caused panic attacks. I had to learn how to breathe to avoid this. http://en.wikipedia.org/wiki/Hyperventilation
« Last Edit: 22/11/2009 00:06:05 by demografx »
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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6130 on: 20/11/2009 13:28:39 »
I don't know if it's relevant but CRH (or CRF) which is released by the hypothalamus to stimulate ACTH secretion, is also involved in the production of beta endorphins.
http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone

Elevated CRF is found in anxiety disorders:
http://www.aolhealth.com/mental-health/learn-about-it/what-causes-anxiety/the-brain

Also dopamine inhibits pituitary hormone release:
http://en.wikipedia.org/wiki/Releasing_hormone
So low dopamine can cause too much secretion of pituitary hormones (?)
I'd like to know which one (except prolactin) if any.
« Last Edit: 20/11/2009 14:13:29 by martin88 »
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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6131 on: 20/11/2009 17:31:27 »
Quote from: goingcrazy on 20/11/2009 06:14:41
I went to the doctor Wednesday and told him about what I have.  He said this is basically post-coital cephalgia, or headaches.  I told him how I wake up in the morning with fog and that it causes extreme anxiety when I do it.  He told me that hes seen a lot of patients with orgasmic headaches, and that my symptoms could just have to do with blood vessel constriction.  I've been doing breathing exercises the past couple of days now and I do notice a difference.  I did "O" last night, and last weekend, with no POIS except extreme tiredness after "O", no anxiety what-so-ever.  I doubt if POIS could just be a symptom of blood vessel constriction but still we do not know what the true cause is.  He is having me sent back this coming Tuesday to examine my "circle of willis", which is a cluster of blood vessels that supply the brain.

I really want you guys to try this, just really quick, breathe about 30 times as deep as you can and as fast as you can and tell me if you experience a weird feeling, but feel better afterwards, I think doing this tends to increase blood flow and open up blood vessels.

isn't search for "cirle of willis" require a scan. If it does what type.
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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6132 on: 20/11/2009 19:51:06 »
Quote from: demografx on 19/11/2009 18:19:07
To email Oprah:
https://www.oprah.com/plugform.jsp?plugId=220



Unbelievable! CNN has just announced that Oprah has quit her talk show! Just at the perfect time for us!! First the AACE now Oprah!! Could anything go worse? But no worries guys....the King is still here and his name is Larry.....

Anyone got his email?  :o)
« Last Edit: 20/11/2009 19:59:31 by Z_one »
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6133 on: 20/11/2009 20:56:28 »

Z_one,

Larry King Live EMAIL
http://www.cnn.com/feedback/forms/form5.lkl.comment.html?12
« Last Edit: 20/11/2009 21:22:22 by demografx »
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6134 on: 20/11/2009 21:18:39 »

Quote from: Z_one on 20/11/2009 19:51:06

Unbelievable! CNN has just announced that Oprah has quit her talk show!



Z_one, yes, I heard that Oprah quit because she knew that we were about to contact her!  [;D]





"Oh no, it's the Guys From POIS!"
« Last Edit: 21/11/2009 03:03:42 by demografx »
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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6135 on: 20/11/2009 23:01:03 »
http://en.wikipedia.org/wiki/Ergoloid

"Current studies imply that the major effect of hydergine may be the modulation of synaptic neurotransmission"

I wonder if Hydergine (brand name) would have any positive affect on POIS.

OK ok ok i really need to get off my ass and get to the freakin med library finally. tbqh, i havent yet because if it turns out to be a dead end i am just going to get really really pissed off, and when i get that pissed off i become very self destructive, so i have been avoiding going over there... but i have next week off so hopefully i can talk myself into it. i think just letting a med student know about all the research done in this forum alone would be freakin enticing for a final thesis.
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6136 on: 21/11/2009 00:07:41 »
B_Jim, Z_one, Martin, thank you very much for clarifying endorphins vs. dopamine!
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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6137 on: 21/11/2009 02:51:12 »

Dr Andrew Weil (MD) takes a look at Hydergine
http://www.drweil.com/drw/u/id/QAA360809

He does sell products, but has always struck me as a very credible guy. From wikipedia:
http://en.wikipedia.org/wiki/Andrew_Weil

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6138 on: 21/11/2009 07:02:07 »
Quote from: demografx on 20/11/2009 21:18:39
Quote from: Z_one on 20/11/2009 19:51:06
Unbelievable! CNN has just announced that Oprah has quit her talk show!
Z_one, yes, I heard that Oprah quit because she knew that we were about to contact her!  [;D]

"Oh no, it's the Guys From POIS!"

Z_one, all's not lost. Oprah will stay thru 2010. And 2011 she'll simply do her own TV thing, raking in billions more. So    she is still a viable prospect!
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Offline Porke

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6139 on: 21/11/2009 13:02:21 »
Quote from: pauliebaby61 on 20/11/2009 02:24:27
Just got back from my Dr's appt. My Dr agreed with Dr in's theory about what happens to our body at O, because it IS what happens at O.
He did not think much of the products Dr Lin sells.
He did not RX SSRI's to me. He said they were not the answer and would probably have a negative effect for pois.
He felt the main culprit here is low dopamine level.He said that is the main transmitter and responsible for the good feelings we get from O. If enough isnt present, the response will be bad and exhausting.

His treatment is 3 herbal suppliments that are precursers to dopamine and seratonin. 1] 5HTP[for seratonin], 2] Mucuna[for dopamine] 3] a product high in selenium. He said he treats Parkins patients much in the same way, with good success getting rid of their tremors.

He says all 3 will increase my dopamine level. He said that the main neurotransmitter after O, which gives us a good feeling after O is dopamine.He explained that if we are low in dopamine, the bodys response to O is negative. Over time,,If we abstain, the bodys dopamine level slowly rises into the normal range, only to be depleted after the next time in the bedroom.
He felt the main cause, for me anyway, was a dopamine deficiency, and also low seratonin.


Interesting. Wonder why he doesnt prescribe l-dopa directly then. This is the dopamine boosting drug used in altzheimers patients. Mucuna is just the herb, and purity could be questionable.
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