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Quote from: demografx on 24/01/2011 21:31:54I just wrote to Dr Christina Wang, one of the principal investigators of the male contraceptive study, to see what their status is. (Started in May, 2010 with a $1.5 million grant).demo if you ever hear back from Dr. Wang, see if you can find out what progesterone/testosterone combination they are using and the dosage, route, and frequency.
I just wrote to Dr Christina Wang, one of the principal investigators of the male contraceptive study, to see what their status is. (Started in May, 2010 with a $1.5 million grant).
Quote from: daveman on 24/01/2011 16:50:29Calcium channel blockers and Adjudin permit sperm production although the sperm may be non-viable, however it may not guaranttee prevention of allergy because valid sperm material is present.I understand exactly what you're saying but I wouldnt rule them out so quick......We know Testosterone has been found to help POIS.Could it be Testosterone helps POIS because Testosterone changes the structure (protein structure) of semen, this then, in turn, prevents the allergic reaction?Perhaps changing the structure of semen prevents the allergic reaction??As Calcium channel blockers and Adjudin both also change the structure of semen, they could prevent an allergic reaction?In regards to SilodosinFrom http://en.wikipedia.org/wiki/Silodosin"Since silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other side, the high selectivity seems to cause more problems with ejaculation.[3]As α1A adrenoceptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm, a trial with 15 male volunteers was conducted. While silodosin was completely efficacious in preventing the release of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation.[4] Despite the incidence of side effects, the drug still appears to be a promising candidate for a male oral contraceptive drug."This is a little disappointing to read "12 out of the 15 patients reported mild discomfort upon orgasm".But wait, think about it, if we learn more on what causes "discomfort upon orgasm" perhaps we will all learn more about the causes of POIS. (although, of course, POIS is discomfort after orgasm). If a drug can do the opposite of Silodosin then perhaps we are on to a winner. But if Silodosin is found to prevent POIS, Id be willing to put up with discomfort on orgasm if it prevents a week of feeling awful after.Is this the first drug to be reported to cause "discomfort upon orgasm"? Very interesting.Phenoxybenzaminehttp://en.wikipedia.org/wiki/PhenoxybenzaminePhenoxybenzamine (marketed under the trade name Dibenzyline) is a non-specific, irreversible alpha antagonist.Uses It is used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer lasting effect compared with other alpha blockers.It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia,[1] although it is currently seldom used for that indication due to unfavourable side effects.It has been used in the treatment of hypoplastic left heart syndrome.[2]It is also used in Complex Regional Pain Syndrome Type 1 due to its anti-adrenergic affects. It has shown to be beneficial if used in the first 3 months of CRPS diagnosis.Phenoxybenzamine has long been known to block ejaculation without affecting semen quality or ability to achieve orgasm, which could make it an effective male contraceptive. This effect is completely reversible, and is believed to be the result of alpha-1 adrenoceptor blockade in the longitudinal muscles of the vas deferens.[3][4][5] As of 2008, research was underway to identify possible drug candidates that share this effect but act specifically on the reproductive tract, unlike phenoxybenzamine.[3]Not sure if this is a good thing or bad thing but "blockade in the longitudinal muscles of the vas deferens" sounds interesting to me as I have a pet theory those Vas Deferen muscles are the key to my POIS problem.
Calcium channel blockers and Adjudin permit sperm production although the sperm may be non-viable, however it may not guaranttee prevention of allergy because valid sperm material is present.
For those interested in the norethisterone-progesterone studyFrom: Christina Wang, MDDate: January 24, 2011 1:31:33 PM PSTTo: demografxCc: Elizabeth Ruiz Ronald S SwerdloffSubject: RE: Male conraceptive studyWe are currently completing a study and will be starting a study on a new oral androgen to see whether this agent will be tolerated in healthy men and to do preliminary studies on how effective this may be. We will let you know when the recruitment of this study starts. Christina Wang, MDProgram Director,General Clinical Research CenterHarbor-UCLA Medical Center and Los Angeles Biomedical Research InstituteProfessor of Medicine,David Geffen School of Medicine at UCLAFrom: demografxSent: Monday, January 24, 2011 1:09 PMTo: Christina Wang, MDSubject: Male conraceptive study Dear Dr Wang, We communicated about one year ago. If you recall, I moderate an internet forum of people who are very interested in your work. Can you please tell me briefly the status of the male contraceptive study/investigation? Many thanks, [demografx]
Quote from: demografx on 24/01/2011 21:35:52Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-map [nofollow]PM "mat780" for more details.thanks, demo
Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-map [nofollow]PM "mat780" for more details.
Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks.
Quote from: lauracostis on 24/01/2011 22:00:20Quote from: demografx on 24/01/2011 21:31:54I just wrote to Dr Christina Wang, one of the principal investigators of the male contraceptive study, to see what their status is. (Started in May, 2010 with a $1.5 million grant).demo if you ever hear back from Dr. Wang, see if you can find out what progesterone/testosterone combination they are using and the dosage, route, and frequency. Please! This interests me greatly too!
Quote from: Animus on 24/01/2011 22:02:17Quote from: demografx on 24/01/2011 21:35:52Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-mapPM "mat780" for more details.thanks, demoDear All,If anyone still wants to join our POIS Map, you can do it !!! We are nineteen Forum Members right now on the Map.As you may guess, this map is not intended to be just something nice for our website;it’s a research tool. From this map, very interesting conclusions can be extracted, oncea certain number of members are involved.Thank you very much!Regards,MatHow can you join? Send me a Private Message with your location (your Country plus your state/province).Member’s data will remain private, so your location will never be associated with your username.Take a look at the POIS Map following this link:http://sites.google.com/site/poiswebsite/pois-map
Quote from: demografx on 24/01/2011 21:35:52Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-mapPM "mat780" for more details.thanks, demo
Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-mapPM "mat780" for more details.
[]Attention all West Coast POIS sufferers!! []Please contact me if you live in California, or in San Francisco! I would like to form a local support group of POIS members, where if we get together we might be able to accomplish more, share resources, and information! I know of some good doctors in this area, and it would be great to meet you. Together we might be able to have more leverage with the medical community.Please PM me. [/size]
Frankly the POIS symptoms feel like I'm being punished for my sexual activity (masturbating, having sex) by some higher power.
I am so glad to have come across this website and information about POIS. I have been searching for the answer to my problem for many years but I feel I may have now found a name to go with my problem - POIS.Here is how it has effected me...I am 32 years old and I had my first symptoms at the age of about 14 or 15. Firstly I had back pains that seemed to get considerably worst when I masturbated but I thought this was just due to a martial arts injury and maybe partly it was. A little while later I started to get chest pains after masturbating which I found very worrying and thought I had been over masturbating. As a young teenager I used to masturbate heavily and felt very shameful of this. I had some tests done at the hospital and was told I have a very healthy heart and that it must be some form of anxiety. At first I excepted this because I felt shameful and thought maybe it was just brought on by guilt. I became doubtful as the years went on though. As I reached late teens and early twenties other symptoms had started to happen. Exhaustion, aching pains, pins and needles and leg cramps although the chest pains stopped for several years and so did the back pain.As I reached my mid 20's the chest pains started to come back along with more extreme fatigue, confusion, not being able to think straight or hold conversation properly or listen properly. Feeling of being cold and aching (like mild flu type aching that just makes everything seem such a huge effort and my joints being more painful). From my late 20's I started to find I would get congested after sex as well, runny nose, sore eyes and sneezing. It's always kind of feels that sex has taking all of my ability to function properly and leaves me totally drained, a shadow of myself. Sometimes I get ratty and uncontrollably irritable and fidgety when trying to concentrate on a task at hand or answer a question. It makes me feel depressed and leaves me with a much duller view of the world and I get less enjoyment out of the things I do. I feel a huge need to just sleep but sleep does nothing to make the symptoms go away, although while I'm laying doing nothing it makes it easier to tolerate. The strange thing is that the severity of the symptoms can vary considerably and I can't seem to find a pattern. Sometimes I suffer really bad for 4 or 5 days and other times I may not notice much at all. It doesn't seem to be connected to my diet (I am a pretty healthy eater). Sometimes if I go for a long time without sex then when I do it it's not too bad. Bad other times like this weekend it felt more severe. Last week I was feeling really good, motivated, being very productive at work, out running a few evenings etc. After having sex on Friday this week is a very different story. So far the most productive thing I have done at work this week is write this email.Recently the chest pains has been increasingly worse and make me fear having an attack, sometimes the pain spreads down my arm. In fact this past weekend I ended up going to hospital after feeling pain in my chest which made me feel very worried but I was told the usual thing that nothing is wrong (which I have been told by several doctors over the years). Palpitations are another problem and these are very inconsistent but uncomfortable when they happen, I can feel my heart beating through my chest without needing to put my hand on it. In fact I can usually just look down and see my chest moving up and down with each beat. I usually only have sex about 1or 2 times a month and try not to have sex if I have anything important to do in the following days. I usually write those off as days of just coping! Sometimes exercise can help and other times it makes me worse or gives me worse chest cramps or painful knees etc. The knees to me seem even more strange than the rest of the symptoms but my left knee in particular gets much more painful after sex when trying to climb stairs or run.I am desperate to find a solution to this problem as I feel that it has held me back so much in life including socially, physically and probably my drive to have a more successful career. My wife is very patient but as you can imagine it takes it's toll on and our sex life and our day to day interaction.
With this skinprick test, how many days after the ejaculation, should it be carried out?
Her final note back to me was terse and said they cannot help.