[demografx]

My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.

Should be interesting!

Wow!!

[daveman]

Well that disturbs me Daveman altering the blood flow to the brain had a direct effect on my pois symptoms???

LOL, Unconcsiousness will do that. [][]

As for the opposed like thyroid symptoms, yes, this POIS thing IS a  b i t c h!
I'm not sure that POIS althers that thyroid cycles though, just makes you feel similar to both thyroid ailments.

[daveman]

Just one week from today, February 18, will be the 4th Year Anniversary of "John21"'s very first POIS post here!

FANTASTIC DEMO !!

..and ever since that time ewe have proven yourself to be the foundation of this thread !!

Others of course deserve praise also but ewe keep the ball rolling !!

WELL DONE and CONGRATULATIONS !!

ewe?  Yeah, maybe we should organize a national POIS convention and bake John a cake.

AND Demo

[demografx]

Many thanks, Neil (aka Sheepy)! Without ewe and ewer support, I would not still be here!

[demografx]

Many thanks, daveman!

[Vandemolen3]

I was finally able to go over Waldinger’s reports. I am now more convinced that it could indeed be an allergic response. There has been some discussion here on how this might occur physically for us. I am wondering if the origin of POIS could lie in the method of sex. My history: I developed POIS within a short time of becoming sexually active,  I’m guessing less than two years, maybe even one. I started masturbating when I discovered that climbing a clothes line pole felt good for some reason, and came to love it and it became a habit. I then found a way to take it indoors by hanging off my bedroom door by holding on to the door handles. I did this for a while before I could even orgasm, and when I did orgasm I was utterly shocked at what came out! So I am wondering if the unnatural method put a high amount of stress on particular parts of the anatomy.

From Waldinger’s Part1:

For example, it may be argued that the specific
immune response underlying POIS symptoms is
initiated by seminal fluid after having been in
contact with the inner mucosal epithelium of the
urethra.

Could this form of masturbation have damaged the urethra repeatedly and initiated an autoimmune response?  Has anyone else experienced the onset of POIS following a change in method or intensity of masturbation or sex?

My urethra was checked from the inside when I was in POIS. There was nothing to see.
We have this semen allergy just because of our genes not because of too much masturbation.

[Guthrie]

My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens. Should be interesting!

Hurray--what are the effects of Silodosin's stopping of semen emissions?  Does it fully stop semen from 'moving' at all?  Or is it that it still moves somewhat internally, but just doesn't make it out?

If it stops the semen from moving entirely, that will be a great test--that way, you'll have orgasm with no semen moving: so if you still get POIS, that will indicate something!  (Likewise if you don't get POIS.)

And with you testing this, it can serve as a good comparison for someone eventually testing the testosterone-progesterone contraceptive treatment, which stops sperm production, but still involves emission of (spermless) semen.

[Guthrie]

Hmm, some google searches mention 'retrograde ejaculation,' but this study of Silodosin:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834370/?tool=pmcentrez
says:

There were no sperms in urine after ejaculation under silodosin administration in any participant. Thus, the ejaculatory dysfunction caused by silodosin was a loss of seminal emission, not retrograde ejaculation.

and

In this study, in spite of anejaculation, orgasm was preserved, although participants reported a slightly unusual feeling. When the orgasm with ejaculatory dysfunction induced by silodosin administration occurred, the increased pressure in the posterior urethra never happened because of the complete lack of seminal emission and expulsion. In addition, the sensory stimuli arising from the verumontanum did not occur because semen did not pass through the urethra. The complete lack of seminal emission suggested that the contraction of seminal vesicles was also suppressed. It is speculated that orgasm is induced by only the contraction of the urethral bulb, which may be maintained even under silodosin administration.

So, as far as this description is concerned, that seems to indicate a full 'non-movement' of semen.

[demografx]

carlitto, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:


Our POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat


* Most recent POIS Research Studies, 2011 *

If you will send Prof. dr. Waldinger an e-mail, stating that you have read his message on the Forum, at http://www.thenakedscientists.com/forum/index.php?topic=6576.msg340138#msg340138 and that you are willing to fill in a questionnaire, he will send you the copies of both 2011 research articles by return through email. At a later date, he will send you the questionnaire which, after having filled in, you should send him back by e-mail.
His email:
prof.dr.waldinger.pois@gmail.com

Prof. dr. Marcel D. Waldinger's website:
http://www.post-orgasmic-illness-syndrome.com/en/index.html


First POIS Research Study, 2002

We have a copy of the first formal medical investigation on POIS by Prof. dr. Marcel D. Waldinger,MD,PhD, and Dr. Dave Schweitzer, MD.

  
Recent POIS Research Study, 2010

CASE REPORT
Postorgasm Illness Syndrome - A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg316781#msg316781


British Medical Journal Case Report, 2010

Case study by Dr. Selwyn Dexter of a patient with a headache-featured POIS symptom treated with progesterone/norethisterone.
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short?rss=1


There are a couple of ways to get any or all of the above 3 studies: (1) if you want a PDF copy, send me a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and I'll send you back the PDF.

Or, if you prefer, (2) I can simply reply with a Private Message (no regular email needed) and provide you with a simple text version embedded in your PM.

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around my name, i.e., "demografx".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the Journal of Sexual Medicine (Dr. Waldinger's study), British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For nearly 4 years, our POIS forum has attracted over 200 POIS sufferers worldwide who have posted here, research on an additional 200 sufferers elsewhere on the internet, plus nearly 1,000,000 page visits. Not bad for a rare malady!

[demografx]

carlitto, this post will help you find information about POIS that we have already discussed, by tailoring a Google search to this forum:


SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: almost 4 years' worth of posts (over  10,000 posts!) from 150+ Forum members, and an additional 150 POIS sufferers found elsewhere on the Internet by Member B_Jim.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://thenakedscientists.com/

for example, I tried
nocturnal emission POIS site:http://thenakedscientists.com/

and 740 results came up for "nocturnal emission" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.

[demografx]

My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.

Should be interesting!

Silodosin side effects:
http://www.drugs.com/sfx/silodosin-side-effects.html

Existing kidney or liver problems can be problematic. These and other useful facts are here:
http://www.healthbanks.com/PatientPortal/MyPractice.aspx?UAID=%7B45ADED82-6E0B-4694-998F-3E0B8E47DC2B%7D&ID=HW5d07354a1&Title=Rapaflo

[daveman]

My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.

Should be interesting!

Silodosin side effects:
http://www.drugs.com/sfx/silodosin-side-effects.html

It reports retrograde ejaculation as a side effect in 28%. Would that mean that it only produces spermless semen in 28% of those who use it?

Edit: Its principal use is in eleviating the symptoms of oversized prostates by relaxing the muscles of the prostate and bladder. It seems that this has a side effect of producing retograde ejaculation.... in 28%.
 
That taken with Guthrie's post above is a little confusing. It could be that it stops sperm production entirely, but due to the relaxed muscles the semen backfires in some cases.

So that hurray's test is 100% productive, especially if it produces a negative result, we will have to know what it is actually doing to his semen.

Sorry Demo, I'd like to see hurray's semen too!

[Guthrie]

My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.

Should be interesting!

Silodosin side effects:
http://www.drugs.com/sfx/silodosin-side-effects.html

It reports retrograde ejaculation as a side effect in 28%. Would that mean that it only produces spermless semen in 28% of those who use it?

Edit: Its principal use is in eleviating the symptoms of oversized prostates by relaxing the muscles of the prostate and bladder. It seems that this has a side effect of producing retograde ejaculation.... in 28%.
 
That taken with Guthrie's post above is a little confusing. It could be that it stops sperm production entirely, but due to the relaxed muscles the semen backfires in some cases.

So that hurray's test is 100% productive, especially if it produces a negative result, we will have to know what it is actually doing to his semen.

Sorry Demo, I'd like to see hurray's semen too!

Daveman, I think that the 'side effects' website with the "28% retrograde ejaculation" may simply be referring to the fact that no semen is expelled.  That is, they don't say, for example, "retrograde ejaculation in 28% and anejaculation in 46%."  So what they are calling 'retrograde ejaculation' may in fact be no movement of semen (rather than redirection of semen into the bladder, i.e. what 'retrograde ejaculation' normally means). 

I agree that it is confusing, but since the article that I linked to specifically distinguished between retrograde ejaculation and anejaculation, and emphasized that it was the latter, this makes me think that the 'side effects' site may simply be imprecise.  Or at least, that's my best attempt at reconciling the apparently conflicting information!

[Guthrie]

With regard to the question of 'retrograde ejaculation', here is a more recent article:
http://www.europeanurology.com/article/S1569-9056%2810%2900053-9/fulltext

It says:

Retrograde ejaculation does not appear to be particularly bothersome. Whereas >20% of patients reported this adverse effect, only 3.9% discontinued treatment because of it. Furthermore, this effect is fully and promptly reversible within a few days after discontinuation of treatment [8]. The most likely explanation for the difference between the occurrence rate and discontinuation rate is that patients with lower urinary tract symptoms (LUTS) often suffer from initial sexual dysfunction, including diminished ejaculation, independent of any subsequent treatment [16]. This effect was historically called retrograde ejaculation, because it was believed that failure to ejaculate was the result of smooth muscle relaxation in the prostate, urethra, and bladder neck leading to abnormal urethral flow, as is the case after transurethral resection of the prostate. However, recent studies have shown that the mechanism is rather a loss of seminal emission resulting from relaxation of the vas deferens [17], and [18]. Thus, the correct term for the observed effect is anejaculation. An unresolved issue is whether anejaculation has an impact on the quality of orgasm. According to a preliminary randomised, double-blind crossover study in 15 healthy volunteers, orgasm is preserved regardless of ejaculatory dysfunction [19].

So it does seem that it is not actually 'retrograde ejaculation.'

[CertainlyPOIS]

CC...presentation on POIS by Khan???

Please say more!!

That is what i said he gave a lecture without contacting the forum and he is an immunologist.
I sent a letter about pois and the lady responded he gave lecture on topic so i hope she means pois and not just semen allergy.
He is an immunologist at ut southwesetern in dallas. Am hoping he accepts doing the treatment because he has connections with university hospital.
The only problems  is i  cant  find  his email and i hope when i call him whoever picks up is a little knowledge and dosent tell me crap. 

[CertainlyPOIS]

vincent marcus;
I am also working on coming up with something to reduce nocturnal emission. I sleep in a certain position to avoid ne's but the moment i start moving around i get ne's so i am working on a way to stop moving while sleeping but still get good rest.
The Chasity belt is definitely  a good idea i didn't even think those exist.

Why do you do so much Big O's that must be putting stress on social life and personally i believe if pois is related to inflammation like dr waldinger says then  in the long run  constant pois is going affect out pois wellbeing.

[GoingCrazy]

Just one week from today, February 18, will be the 4th Year Anniversary of "John21"'s very first POIS post here!

FANTASTIC DEMO !!

..and ever since that time ewe have proven yourself to be the foundation of this thread !!

Others of course deserve praise also but ewe keep the ball rolling !!

WELL DONE and CONGRATULATIONS !!

ewe?  Yeah, maybe we should organize a national POIS convention and bake John a cake.

AND Demo

Demo will get first slice

[demografx]

First slice? YAY!!!

[demografx]

Yeah, maybe we should organize a national POIS convention...

Let's all thank GoingCrazy for his oh-so-generous gesture of paying for _all_ our travel, hotel and ANY miscellaneous expenses (e.g., lavish presents for the special someones) to Tahiti this December, 2011 for The First Annual International POIS Forum Conference! (He said invite friends and family, too, including mistresses/lovers...even babysitters, pets, kids' friends, and their parents!! It's all on him!! Unlimited, really!)

Hurrah, GoingCrazy!!

[demografx]

(waiting patiently for my round trip tickets)