[horizon]

Calcium channel blockers and Adjudin permit sperm production although the sperm may be non-viable, however it may not guaranttee prevention of allergy because valid sperm material is present.

I understand exactly what you're saying but I wouldnt rule them out so quick...

...We know Testosterone has been found to help POIS.
Could it be Testosterone helps POIS because Testosterone changes the structure (protein structure) of semen, this then, in turn, prevents the allergic reaction?

Perhaps changing the structure of semen prevents the allergic reaction??

As Calcium channel blockers and Adjudin both also change the structure of semen, they could prevent an allergic reaction?

In regards to Silodosin
From http://en.wikipedia.org/wiki/Silodosin
"Since silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other side, the high selectivity seems to cause more problems with ejaculation.[3]

As α1A adrenoceptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm, a trial with 15 male volunteers was conducted. While silodosin was completely efficacious in preventing the release of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation.[4] Despite the incidence of side effects, the drug still appears to be a promising candidate for a male oral contraceptive drug."

This is a little disappointing to read "12 out of the 15 patients reported mild discomfort upon orgasm".
But wait, think about it, if we learn more on what causes "discomfort upon orgasm" perhaps we will all learn more about the causes of POIS. (although, of course, POIS is discomfort after orgasm). If a drug can do the opposite of Silodosin then perhaps we are on to a winner.
But if Silodosin is found to prevent POIS, Id be willing to put up with discomfort on orgasm if it prevents a week of feeling awful after.
Is this the first drug to be reported to cause "discomfort upon orgasm"? Very interesting.

Phenoxybenzamine
http://en.wikipedia.org/wiki/Phenoxybenzamine

Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-specific, irreversible alpha antagonist.

Uses
It is used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer lasting effect compared with other alpha blockers.

It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia,[1] although it is currently seldom used for that indication due to unfavourable side effects.
It has been used in the treatment of hypoplastic left heart syndrome.[2]
It is also used in Complex Regional Pain Syndrome Type 1 due to its anti-adrenergic affects. It has shown to be beneficial if used in the first 3 months of CRPS diagnosis.

Phenoxybenzamine has long been known to block ejaculation without affecting semen quality or ability to achieve orgasm, which could make it an effective male contraceptive. This effect is completely reversible, and is believed to be the result of alpha-1 adrenoceptor blockade in the longitudinal muscles of the vas deferens.[3][4][5] As of 2008, research was underway to identify possible drug candidates that share this effect but act specifically on the reproductive tract, unlike phenoxybenzamine.[3]

Not sure if this is a good thing or bad thing but "blockade in the longitudinal muscles of the vas deferens" sounds interesting to me as I have a pet theory those Vas Deferen muscles are the key to my POIS problem.

Great information horizon. Looks like there's something for everyone. Would be great if we could set up volunteers for each of the processes, those who "feel" that one or the other would be better for them. Perhaps some great advances could be made.

Hi Hurray,
I was just wondering if there was a reason you choose Silodosin over Phenoxybenzamine to try? Or was it purely a random choice?
thanks

[hurray]

Hi Horizon,

It was you that inspired me to try it out in the first place, so thanks for that!  []

It was a bit random, the fact that a pharmacy that I know and trust had Silodyx in stock (but not Phenoxybenzmine) was probably the deciding factor - decent pharmacies are like gold dust.

To answer CCconfucius - I've now had 2 O's in the name of science, and semen was completely absent both times. No semen in my urine either, so it would seem as if the semen isn't going anywhere. I deliberately prolonged the second O - to my disappointment, some pre-cum arrived after about 30 minutes. Unfortunately, the arrival of pre-cum usually triggers some POIS symptoms for me, although these are not usually as bad as full-scale POIS. My POIS symptoms only came to light after my second O, and did not include the usual brain fog and social phobia that full POIS would normally give me. I don't want to describe my "POIS symptoms" in too much detail, in case they turn out to be Silodosin side-effects.

I'm not thrilled with the side-effects that Silodosin gives me - light-headedness and sleepiness - so I've temporarily stopped taking it. This should give my brain/body chance to recover - two Os in quick succession would normally ruin my week. The next time I try it I will take 8mg a few hours before O and see if it works "on demand". Another thing I would like to find out is if 1 4mg tablet does enough to block ejaculation - if so, I could have the same anti-POIS benefits with fewer side-effects.

Will post again soon.

[makrofag]

You shouldn't worry about the sleepiness since that is the typical effect at the beginning of taking of the alpha and beta blockers. People usually have more than one side effect when beginning the treatment so consider yourself lucky.

Also alpha blockers in general have an effect against anxieties/flight-or-fight states but not as much as some beta blockers do. So in the end it's maybe the androgen blocking effect and not the blocking effect of sperm expulsion. I have used beta blockers extensively to help my problems while in the post orgasmic state. But the thing is I was prescribed Flomax for my frequent urination which is an alpha blocker and I have had many interesting experiences with it. While on the alpha blocker I had hard to achieve orgasms, weak orgasms in terms of satisfaction but much less post orgasmic problems, also retrograde ejaculation and ejaculation with a partial orgasm - no post orgasmic effects at all with this one. Maybe it'll be great if more people started experimenting as these drugs are relatively safe and your uro or endo can prescribe them to you without having feeling bad.

[CertainlyPOIS]

hurray i am curious how quickly you will have a nocturnal emission

[demografx]

makrofag, I'm a little off topic, but Flomax didn't work for my OAB. None of that Rx class did/does, but I'll be damned if I go get Botox injections into my bladder. The only options, except for experimental Vasopressin and/or acupuncture, neither of which I'm willing to try.

[hurray]

Thanks for your insightful comments, makrofag. Are you suggesting that the sleepiness is a temporary effect that will soon wear off? If so that would be great - the sleepiness I have experienced so far would have the potential to mess up my work, family and social life as badly as POIS  []

The effect on my thought processes before/after orgasm seemed a lot different to an anxiety/fight-or-flight issue. After O #1, I could feel I still had access to the parts of my brain that deal with creativity, sociability etc, the "brain fog" wasn't there. Unfortunately I felt like going to sleep all the time!

I will be interested in the possibility of NEs also - haven't had one for years, but I haven't gone much over 2 weeks without orgasm in that time either. I start to feel mental tension if I leave it for much over a week, which gradually increases. I was expecting a "blue balls" type of effect - painful testes and increased mental tension - but at least for now, it feels superficially like I have had a full O and my body has "rebooted", as per my pre-POIS experiences.

Interesting that you have taken a similar class of drugs already Demo!

[Habibou]

The effect on my thought processes before/after orgasm seemed a lot different to an anxiety/fight-or-flight issue. After O #1, I could feel I still had access to the parts of my brain that deal with creativity, sociability etc, the "brain fog" wasn't there. Unfortunately I felt like going to sleep all the time!

Yes, the side effects are the worse at the beginning,and are lighter and lighter after 2 weeks ! so, don't worry about it
It it great you found something like that ! it is worth to try it, I will try asap (if it is sold in france...). Tou said the O was strange, can you explain more if it is possible?

[horizon]

It was you that inspired me to try it out in the first place, so thanks for that!  []
It was a bit random, the fact that a pharmacy that I know and trust had Silodyx in stock (but not Phenoxybenzmine) was probably the deciding factor - decent pharmacies are like gold dust.

well, just be very careful, dont take them if you're feeling unwell, or over do it.

[CertainlyPOIS]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

[daveman]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

Don't bother. Find someone who's motivated. This guy only wants to say "I told you so".
Freaken goofs!

Edit: Hope they didn't have the nerve to charge you!!

[CertainlyPOIS]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

Don't bother. Find someone who's motivated. This guy only wants to say "I told you so".
Freaken goofs!

Edit: Hope they didn't have the nerve to charge you!!

i have goten smarter, i just email them and let them decided with the information i send.

[daveman]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

Don't bother. Find someone who's motivated. This guy only wants to say "I told you so".
Freaken goofs!

Edit: Hope they didn't have the nerve to charge you!!

i have goten smarter, i just email them and let them decided with the information i send.

Jeez... How many years do they study to know if you're alergic to flowers or trees. Body fluids, heck, that's a whole other thing!

Not enough evidence.... yeah for them! I guess one of them needs a good case of POIS!

BTW, can you tell that I'm all riled up? Hey Demo, got a good cartoon for this?

[Nightingale]

An update on my situation:

I received a copy of Dr Waldinger's study (from the man himself!)  Made a copy of it and took it to my allergist's office and wrote a note to my Dr to read it and let me know if she is willing to do the pinprick test up to Waldinger's standards.  2 days later I came back and talked to her.  She told me she had read the entire study (she found it very intriguing!), but she was sorry to say that they just didn't have the equipment necessary to do the test the way Waldinger did.  They don't have the equipment to dilute the sample to 1:40,000 concentration.  She said this is something that a university would be more likely to accomplish.  

She did add a caveat: the regular pinprick test she performed on me was at a 1:1 dilution ratio!  The chances that an intracutaneous 'pinprick' at 1:40,000 dilution ratio would in all probability give me less of a reaction then the pinprick i had already done.

I am not pursuing this any further for now.  I am disappointed this didn't result in any kind of treatment for me.  I am about a week into trying Androgel testosterone gel, and have not seen any changed yet.

[demografx]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

Don't bother. Find someone who's motivated. This guy only wants to say "I told you so".
Freaken goofs!

Edit: Hope they didn't have the nerve to charge you!!

i have goten smarter, i just email them and let them decided with the information i send.

Jeez... How many years do they study to know if you're alergic to flowers or trees. Body fluids, heck, that's a whole other thing!

Not enough evidence.... yeah for them! I guess one of them needs a good case of POIS!

BTW, can you tell that I'm all riled up? Hey Demo, got a good cartoon for this?

This is daveman, calmly and patiently responding to "not enough concrete evidence"

[demografx]

My POIS has always created symptoms that are "unique", different from any other feeling from any other malady in my life. Some of these symptoms are strange and very difficult to describe, even to myself!

I'd be curious to know from others: does your POIS feel different or the same as other malaise, maladies, illness, etc., in your life?

[Vandemolen3]

"Dr. went over the information that you sent to us and said there is not enough concrete evidence that someone is allergic to their own body fluids and he also contacted the head allergy and immunology physician at Southwestern Medical Center in Dallas and he said the same.  He said he was sorry he could not help you.  He also does not know whom he could refer you too."

This is the response from one of the immunologist i contacted.
How am i suppose to respond to that?
still skeptical even with years of reasearch and more than enough suffers to back up the reasearch.

I guess i am going to challenge him and ask him if he is willing to do intradermal test.

It's very easy to say that there is not enough concrete evidence. If they know it better then they should give an alternative.

Haha Daveman, I know your feeling. I get mad too by this sort of reactions. But they don't know POIS.

[daveman]

My POIS has always created symptoms that are "unique", different from any other feeling from any other malady in my life. Some of these symptoms are strange and very difficult to describe, even to myself!

I'd be curious to know from others: does your POIS feel different or the same as other malaise, maladies, illness, etc., in your life?

When you're out of POIS, the symptoms are hard to reach, the direct sense and memory of them sort of hazes up, details can't be described well. When you're in POIS, you could describe every one, exept that the brain and mouth don't work!

So either way you're screwed. (can I say that?)

Day 2 right now, the brain feels like it has about 3 chipmunks inside scrambling all over the place, knocking furniture over and fighting amongst themselves in that squeaky high pitched voice.

ALVIN!! yes Dave CUT IT OUT go sit on it Dave

[Vandemolen3]

I found out that in POIS I have a lot of plaque. I brush my teeth twice a day. But when in POIS this doesn't help. And then my breath smells. I also have a cough for a few days. This ends when the tonsils stones come out. Or is this scale? My gums are also infected. Almost white.

[demografx]

Day 2 right now, the brain feels like it has about 3 chipmunks inside scrambling all over the place, knocking furniture over and fighting amongst themselves in that squeaky high pitched voice.

ALVIN!! yes Dave CUT IT OUT go sit on it Dave

For those of you who don't remember the 50's  []

[Hoping]

so, I have some good news. As you may recall, several weeks ago I contacted Dr. Ves Dimov at the University of Chicago due to his study:

T. Nguyen, V. Dimov, A. Bewtra. Semen allergy and other allergic disorders of intimacy [P184]. American College of Allergy, Asthma & Immunology (ACAAI) 2010 Annual Meeting. Ann Allergy Asthma Immunol., Vol 105:5, Suppl. 3, A78, Nov 2010.

I wanted to replicated Dr. Waldinger's tests and (possibly) treatment. Dr. Dimov clarified that, although he participated in the study, Dr. Bewtra and Dr. Nguyen were really the driving forces. He recommended I contact them instead. Dr. Bewtra and Dr. Nguyen are at Creighton University in Omaha, NE, USA.
I received an enthusiastic response from Dr. Bewtra and have scheduled an appointment with him in several weeks. Here's his response to me:

Dear <hoping>:
At the outset let me make it clear that I have never treated patients with
POIS. I have however treated females who had developed type I and III immune
reactions to their partner's semen. I have also desensitized a couple of
women with type I reactions to their spouse's semen.
I am very intrigued by your disease and would most definitely try to be of
any help.
Could you call my front desk at ... to schedule an appointment. It would expedite matters if you brought fresh sample of your semen with you and I will be able to perform a ***** skin test that day. That will only give me evidence for a Type I reaction. To test for a type IV reaction the test has to be read at 48 to 72 hours and that would not be possible as you will be back in Chicago. We could do that part of the test at a later date. I know that you would be precipitating your symptoms by bringing the fresh sample but hopefully, I would be able to treat it, if it is indeed an immunologic condition...
Againdra K. Bewtra

I'm speaking with him now to try to get a copy of his study. I figured others would like to hear that SOME allergists are responding to these requests. If anyone is in the Omaha, NE area, send me a PM and I may be able to share Dr. Bewtra's contact information.
I'm more intersted in the type IV testing and will stress the intradermal injections that have been discussed here.