[CertainlyPOIS]

Those of us with just type iv reactions like myself will probally not react to a skinprick test because skinprick test is most efficient for type 1 allergies that involve breakouts and similar symptoms. 
Inorder to stimulate those cytokines that create iv reactions we gonna have to get doctors to get that semen to cytokines through intradermal injections.
intradermal injections is the closest in similarity to what happens in the body when we do the big O. Because urethera is not on the skin it is inside the body.

I totally agree with you !
I guess I also have mostly the IV allergic reaction... and my first skin test (which wasn't an intradermal injection) was negative.

We talked about it earlier but " inject semence directly into the IV type reaction" looks like "intralymphatic administration" (remind: about 2/4 months to cure from a tough allergy, compared to the long time of hyposensitization therapy)

I talked about in a mail with Dr Prof Waldinger, and he said it could be hazardous, but he would contact me later to talk seriously about it. I talked about it with my allergist, she didn't answer yet...

I reread dr waldingers paper and saw a pragraph that explains why probably a lot of us wont react to even Intra-dermal skinprik test.

So pois = type 1 and typeIv reaction
type1 = Ige accumulations
typeiv = T cell mediated disorders which means white blood cells going nuts and and it is antibody independent.

Exact quote " The combined finding of local redness of the skin followed by a flu-like reaction, points to a combination of of TypeI and Iv hypersensitivity initiated by ejaculation.  Morever , IC - intra dermal, inoculations of an allergen  relates to specific IgE - mediated local reaction of the skin, whereas a flu - like syndrome resembles an acute phase response and is mediated by activated T-lymphocytes in contact with monocytes/macrophages to secrete acute phase peptides".

So if you mostly get type IV reactions you might not get skin reaction. Might be why 29/33 reacted to skinprik test.

Which leads me to conclude in addtion to skin test there should be a test related to T-lymphocytes activity after orgasm.

Bjim said we should incorporate the other types of reaction type I - V
we can do that by running test that includes all of them.
Type I ige
Type II igm or igG
type III igG
type Iv  T - lymphocytes
type V - antibodies.

[daveman]

I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to help

And if we had a way to pay Dr. Waldinger to speak to them on our behalf, we might make a lot more progress, safely and efficiently. Also he could benifit some form his efforts.

I'm sure his input could facilitate any interaction tremendously, and everybody wins.

[Vandemolen3]

I reread dr waldingers paper and saw a pragraph that explains why probably a lot of us wont react to even Intra-dermal skinprik test.

So pois = type 1 and typeIv reaction
type1 = Ige accumulations
typeiv = T cell mediated disorders which means white blood cells going nuts and and it is antibody independent.

Exact quote " The combined finding of local redness of the skin followed by a flu-like reaction, points to a combination of of TypeI and Iv hypersensitivity initiated by ejaculation.  Morever , IC - intra dermal, inoculations of an allergen  relates to specific IgE - mediated local reaction of the skin, whereas a flu - like syndrome resembles an acute phase response and is mediated by activated T-lymphocytes in contact with monocytes/macrophages to secrete acute phase peptides".

So if you mostly get type IV reactions you might not get skin reaction. Might be why 29/33 reacted to skinprik test.

Which leads me to conclude in addtion to skin test there should be a test related to T-lymphocytes activity after orgasm.

Bjim said we should incorporate the other types of reaction type I - V
we can do that by running test that includes all of them.
Type I ige
Type II igm or igG
type III igG
type Iv  T - lymphocytes
type V - antibodies.

I already did an IGE test. It was too low. Normally allergic people have a high level of IGE. That's what I heard.

[Habibou]

I reread dr waldingers paper and saw a pragraph that explains why probably a lot of us wont react to even Intra-dermal skinprik test.

So pois = type 1 and typeIv reaction
type1 = Ige accumulations
typeiv = T cell mediated disorders which means white blood cells going nuts and and it is antibody independent.

Exact quote " The combined finding of local redness of the skin followed by a flu-like reaction, points to a combination of of TypeI and Iv hypersensitivity initiated by ejaculation.  Morever , IC - intra dermal, inoculations of an allergen  relates to specific IgE - mediated local reaction of the skin, whereas a flu - like syndrome resembles an acute phase response and is mediated by activated T-lymphocytes in contact with monocytes/macrophages to secrete acute phase peptides".

So if you mostly get type IV reactions you might not get skin reaction. Might be why 29/33 reacted to skinprik test.

Which leads me to conclude in addtion to skin test there should be a test related to T-lymphocytes activity after orgasm.

Bjim said we should incorporate the other types of reaction type I - V
we can do that by running test that includes all of them.
Type I ige
Type II igm or igG
type III igG
type Iv  T - lymphocytes
type V - antibodies.

I already did an IGE test. It was too low. Normally allergic people have a high level of IGE. That's what I heard.

Some weeks ago, I had the following results :
-Ig M =      249%               of the normal avergave
-Ig G =       99%
-Ig A =       49%
-Ig E =      190%

My immun system is totally unbalanced :s I have type I, II, and IV probably

[daveman]

The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even  during the Type IV reaction IgE could return to normal. (barring other allergies).

[demografx]

On February 18, 2007

                                John21


courageously and eloquently

                                                  posted here as the very first POIS-poster


at a place which has now blossomed from that lone voice in the wilderness


to a Worldwide Resource and Network for POIS sufferers!

                                                       
                                                Thank you, John, who is still with us and active today!


                   

Everyone, Demo likes to give me credit for asking a question, but we all know who is really deserving of praise for the work done here. There are more than one, but Demo plays a pivotal role, and I thank him for what he does. When I asked the question I was experiencing POIS and had read online about Waldinger's patients, who had post orgasm "flu like symptoms", and I think that encouraged me. It dawned on me that there could be others out there, and now here we are. Thanks to every person who contributes in whatever capacity they can. Our numbers have increased since the release of Waldinger's reports. As POIS gets more recognized over time, who knows how many lives may be helped by your efforts. Happy anniversary!

Thank you very much, John!!!!

[CertainlyPOIS]

The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even  during the Type IV reaction IgE could return to normal. (barring other allergies).

Or may  be even about like 12 hours after. According to paper type IV reaction occcurs  12- 14 hours.
I looked at my old test, which am sure i took 2-3 days after a big O,but still in pois. my ige,igg,igm,iga and lymphocyte subset panel all came out normal.
I am guessing it is all normal because the allergic reaction is transient so days later all the immune cell activity has stopped but the body still has to recover from all the activity.
Habibou how quickly did you do test.

[CertainlyPOIS]

I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to help

And if we had a way to pay Dr. Waldinger to speak to them on our behalf, we might make a lot more progress, safely and efficiently. Also he could benifit some form his efforts.

I'm sure his input could facilitate any interaction tremendously, and everybody wins.

Yeah that will be great he will have answers for their conclusions we dont have. But he is too busy for something like that to happen even if it was possible for us to raise enough money.

[Habibou]

The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even  during the Type IV reaction IgE could return to normal. (barring other allergies).

Or may  be even about like 12 hours after. According to paper type IV reaction occcurs  12- 14 hours.
I looked at my old test, which am sure i took 2-3 days after a big O,but still in pois. my ige,igg,igm,iga and lymphocyte subset panel all came out normal.
I am guessing it is all normal because the allergic reaction is transient so days later all the immune cell activity has stopped but the body still has to recover from all the activity.
Habibou how quickly did you do test.

I made those tests 2 hours after an O

[Habibou]

Hurray [] do you have some news about Silodosin? thank you !

[Hoping]

I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to help

And if we had a way to pay Dr. Waldinger to speak to them on our behalf, we might make a lot more progress, safely and efficiently. Also he could benifit some form his efforts.

I'm sure his input could facilitate any interaction tremendously, and everybody wins.

Yeah that will be great he will have answers for their conclusions we dont have. But he is too busy for something like that to happen even if it was possible for us to raise enough money.

I would definitely be up for discussing this option with him. As I mentioned a few days ago, I was able to schedule an appointment with allergist Dr. Bewtra at Creighton University who has experience with semen allergy in women. I've tried to contact Dr. W to clarify a few things before my appointment to make sure I'm receiving all of the correct testing. I haven't heard from Dr. W in over a week though []

The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even  during the Type IV reaction IgE could return to normal. (barring other allergies).

Or may  be even about like 12 hours after. According to paper type IV reaction occcurs  12- 14 hours.
I looked at my old test, which am sure i took 2-3 days after a big O,but still in pois. my ige,igg,igm,iga and lymphocyte subset panel all came out normal.
I am guessing it is all normal because the allergic reaction is transient so days later all the immune cell activity has stopped but the body still has to recover from all the activity.
Habibou how quickly did you do test.

I made those tests 2 hours after an O

This is great news! Habibou what sort of test is this? Is it a simple blood test? Did you go to an allergist or a normal physician?
I'm especially interested in being tested for Type IV but am a little unclear about how to do this. Intradermal injections? This is what I hope to explore with Dr. Bewtra.

[hurray]

Hi Habibou,

Yes, more news on the Silodosin.

The first times I tried it (daily 8mg doses followed by O), it successfully stopped ejaculation but had the unpleasant side-effect of making me feel sleepy all the time. Not POIS sleepy, just plain "I want a nap" sleepy, no brain fog.

I stopped taking the daily doses of Silodosin to see if it would work "on demand" (only taking the Silodosin before Os). My first experiment with this was last night, when I took half the recommended dose of Silodosin (1 4mg capsule) to see if it would be sufficient. Sadly, it wasn't - although the amount of semen ejaculated was far less than normal.

I will try another "on demand" test next weekend, this time taking the full 8mg dosage. I hope this will be successful, as I don't want to take alpha blockers every day.

[lauracostis]

Hi Habibou,

Yes, more news on the Silodosin.

The first times I tried it (daily 8mg doses followed by O), it successfully stopped ejaculation but had the unpleasant side-effect of making me feel sleepy all the time. Not POIS sleepy, just plain "I want a nap" sleepy, no brain fog.

I stopped taking the daily doses of Silodosin to see if it would work "on demand" (only taking the Silodosin before Os). My first experiment with this was last night, when I took half the recommended dose of Silodosin (1 4mg capsule) to see if it would be sufficient. Sadly, it wasn't - although the amount of semen ejaculated was far less than normal.

I will try another "on demand" test next weekend, this time taking the full 8mg dosage. I hope this will be successful, as I don't want to take alpha blockers every day.

like a few others have said, maybe Silodosin will be a good drug for preventing NEs.  The sleepy side effects might make it a good candidate for a night time NE blocker if it could be proven that a single dose at bedtime is sufficient to stop ejaculation.  Also, it would be good to know for sure if Silodosin stops pois symptoms when anejaculation occurs.

[Guthrie]

Hi Habibou,

Yes, more news on the Silodosin.

The first times I tried it (daily 8mg doses followed by O), it successfully stopped ejaculation but had the unpleasant side-effect of making me feel sleepy all the time. Not POIS sleepy, just plain "I want a nap" sleepy, no brain fog.

I stopped taking the daily doses of Silodosin to see if it would work "on demand" (only taking the Silodosin before Os). My first experiment with this was last night, when I took half the recommended dose of Silodosin (1 4mg capsule) to see if it would be sufficient. Sadly, it wasn't - although the amount of semen ejaculated was far less than normal.

I will try another "on demand" test next weekend, this time taking the full 8mg dosage. I hope this will be successful, as I don't want to take alpha blockers every day.

Hurray,
If you are aiming for an 'on demand' dosing, it could be helpful to time it in accord with its build-up to its peak concentration:

http://www.medscape.com/viewarticle/733429_3

Maximum plasma concentrations for silodosin were reached on average 2.6 hours after dosing.

Also:
http://www.europeanurology.com/article/S1569-9056%2810%2900053-9/fulltext

Silodosin is readily absorbed from the gut, and peak plasma concentration (Cmax) and area under the curve (AUC) for plasma concentration versus time increase linearly with dose [7]. Absolute bioavailability amounts to approximately 32% [8]. Food blunts Cmax and delays time to Cmax by about 1 h without affecting the AUC. This feature has been exploited by recommending the administration of silodosin with food, ideally during breakfast in the morning, to avoid plasma concentration peaks that could potentially be associated with adverse effects [7], [8], and [9].

[hurray]

I agree lauracostis, I think Silodosin or one of its sister drugs taken regularly could possibly be very helpful for those trying to prevent NEs. Whether or not the benefits outweigh the downsides (Silodosin side-effects) would probably vary between different individuals.

Wide awake on an 8mg dose taken for 3 days, I could feel all the correct muscles expanding and contracting at orgasm time, but there was no ejaculation. There's no doubt that it was a real orgasm.

Only time and repeated efforts will prove if Silodosin works for me - I hope it isn't a false dawn!

Thanks for the links Habibou, very useful information.

[Habibou]

Thank you Hurray !  []
It wasn't me who gave the interesting links^^ But Guthrie.
So , to sum up with Silodosin :

-it doesn't work on the demand with 4 mg pill but reduce the amount of semence.
-it works almost (you talked about after 30 minutes, you got a prefluid) very well with 8mg daily.
-you don't have POIS and the worst symptom (according to me) brain fog.
-you need a nap after an O. (perhaps normal for everybody) how long time the nap?
-the O is quite normal.

The Silodosin side effects aren't really heavy? For you, naps, sleeping disorder?
Why don't you want to take it each day?

I think it would be worth that we try too  [] I personnaly live in France and would like to try it.

[hurray]

Quite right - thank you Guthrie  []

Good summary Habibou, one thing worth mentioning is that many (most?) members of the forum report having problems only after ejaculation - in their cases, sexual activity without ejaculation doesn't lead to them having POIS symptoms.

So Silodosin may well work more effectively for this subset of POIS sufferers than it does for me personally.

The orgasm feels normal physically, mentally it seems to be weaker than a non-Silodosin O - not a great side-effect, but one that I think many people would trade for getting rid of their POIS symptoms.

I don't really feel the need to have a nap after an O, the Silodosin makes me feel sleepier all the time. This may change as my body becomes more accustomed to it.

[Green]

Quite right - thank you Guthrie  []

one thing worth mentioning is that many (most?) members of the forum report having problems only after ejaculation - in their cases, sexual activity without ejaculation doesn't lead to them having POIS symptoms.

It's quite different for me, arousal causes POIS symptoms maybe ~ 20-30% that are short lived, but masturbation without ejaculation still leaves me in a dire state, and to get back to a state of normality would take longer than ejaculating. Also NE's ususally leaves me in a better state, rarely any POIS symptoms, strange.

[alky]

Quite right - thank you Guthrie  []

one thing worth mentioning is that many (most?) members of the forum report having problems only after ejaculation - in their cases, sexual activity without ejaculation doesn't lead to them having POIS symptoms.

It's quite different for me, arousal causes POIS symptoms maybe ~ 20-30% that are short lived, but masturbation without ejaculation still leaves me in a dire state, and to get back to a state of normality would take longer than ejaculating. Also NE's ususally leaves me in a better state, rarely any POIS symptoms, strange.

I`m like u green. Maybe  we dont have allergy reaction to semen but neurotransmitter imbalance . I think we have a problem with neurotransmitters involved in arousal and orgasm ?

What u think ?

[alky]

DEAR ALL,PLZ READ CAREFULLY : Honestly speaking,,,,,and after tons & tons of research; consultations ; research; readings & trial & errors : iv personally &  with respect to all opinions reached to that conclusion : For the general population (except listed exceptions below) POIS is nothing more than neurotransmitters brain deficiency related to excessive & prolonged stress & leading to Chronic fatigue syndrome like symptoms due to depletion of the body's key precursors & nutrients.
Causes :  Prolonged stress/ depression; poor nutrition; single/excessive sex; lack of exercise; pollution; anxiety; traumas & others.,,,
Exceptions : People suffering from preliminary disorders such as : Autoimmune; adrenal exhaustion; hormonal imbalance; STDs * others,,,,,,Usually those suffering from any single or combined of any of the above will suffer additional symptoms like allergies; fever; anorexia; pain and depending on each and every case ( Remember each and everyone is very different while the human body itself is very complex---> That is why there can't be a universal cure for everyone,,,,because each case needs to be tackled; diagnosed & treated differently and that is exactly why we have so many different cases & claimed cures on this forum,,,because every tested/ cured member is different!) 
Treatment cure for the general population : Gradually replenish serotonin & other neurotransmitter deficiency using natural MAOIS; exercise; sun baths; healthy nutrition; stress reduction ; relaxation techniques& others,,,,,Use of homeopathy & herbal medicine to re-balance the system & reach homeostasis during exhaustion & recovery phases.
Conclusion: To me & thx God after lots of suffering & hard work POIS is a closed case now! Though I still suffer from undesired symptoms from time to time ; Iam 100% aware of what it is going on with my system & specifically inside my brain . In addition I fully understand the thirst of POIS sufferers like me to learn & know more & get into the nifty tiny details,,,,but trust me the problem AND solution for the general population,,,,is much much MUCH simpler than it seems,,,,,Sometimes we drawn into the details & forget the big picture,,,,,,and that has in my opinion has been the case for POIS ,,,and again with my deepest respect to all researchers; specialists; active members; & moderators of this forum,,,,,get well everyone.
Regards,

Hello z-one. can u post more about this ?

maybe there are 2 types of pois : allergy and neurotransmitter related

a minority of people here have symptoms only from arousal or masturbation without ejaculation.. so maybe semen is not involved?

let`s discuss all possibilities guys thanks