[Starsky]

XN, 1000mg slow release pills dont work. I took 1 pill at 12 and after a while i felt light warm feeling in my face, had O. after 2h. What i feel: tension inside my head, you know what i mean, and im very tired and lazy. So im POISed

On the leaflet its sait 1000mg for 6-8 hours release. So after 2h i should have taken 300mg XN but as I said, it must be a quick action.

[Quasar]

Hi all! I'm new. I'm from Europe, Spain. I think i suffer from POIS since i was 14 years old. I remember i began to suffer from brain fog and scalp pain and i didn't know what it was. Then one day i tried to stop masturbating for 1 week, and bingo! the symptoms were gone. I felt great. But stopping to masturbate is a difficult task. For the next years the symptoms have been more severe. What i experience now (30 year old) after masturbation:

- Dry skin (my face and body become dehydrated)
- Scalp pain: after masturbation my scalp is very tender to the touch
- Low energy
- Diziness when i stand up suddenly: orthostatic intolerance
- Strange feeling around my heart. Heart beats are more strong
- Severe hair loss
- Depressive and melancholic feelings

The only thing that helps me after POIS is going out and doing some jogging. Exercice helps me a lot. I don't know what i would do without exercice...Probably kill myself LOL.

Sometimes i think it is a cardiovascular issue. I mean, one part of the problem is when i have an orgasm, i can feel capillaries dilate! Specially in my scalp. I that's what's making the problem later. So, I know some of you tried Beta Blockers, and didn't work for you, but i still think it makes a lot of sense to try to prevent that capillary dilation in the first place.

When i have a dry orgasm, i can't feel the capillaries dilate in the same way. So, there we have a clue.

Also, i found interesting the Histamine issue, because it is also related with capillaries, and allergies.

I don't know if this page is a scam, but here it goes: http://www.restoreunity.org/natural_method_antihistamine.htm

It points out natural methods to stop histamine. It says this about Niacin:

"4.      Supplement the form of niacin called inositol hexanicotinate.  It can cross the blood brain barrier more effectively than niacin.  It has no flush, while niacin has a flush.  Niacin can increase cell membrane permeability.  Increasing cell permeability can improve the ability of supplements to penetrate into cells.  Dr. Bob advised 100 mg of hexanicotinate in the AM along with methionine supplementation. "

Also, i find it interesting to try Finasteride. It blocks DHT. Sometimes after masturbating i feel the problem could be converting too much testosterone to DHT. That would explain the huge hair loss i suffer instantly after masturbation.

Sorry for the long post!

[demografx]

Quasar, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:

Our new POIS Forum - architectural genius: "daveman" - for detailed subject-by-subject discussion!
http://www.POISCenter.com/forums/index.php
Our 4-year-old POIS thread here at Naked Science Forum will also always remain open for newcomers, for general unstructured discussion, and historical research of the 10,000+ postings here since 2007.

The Learning Channel's (TLC)  feature TV presentation on POIS, featuring our member here at this forum, "Animus". It was aired on May 22, 2011. Here is a link to the file for that TV documentary, "Desperate Measures", which can be downloaded and played. The segment starts at about 12:20..
http://www.fileserve.com/file/cUtJa9R/TITLE01.mp4

Our POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

The POIS Information Website is home to the famous POIS Forum Compendium, written by "Pyropeach", and contains theories already discussed here and treatments that have both worked and failed.

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat


POIS Research Studies, 2011

These 2 papers reveal Dr. Waldinger's POIS autoimmune hypothesis and suggests one possible avenue of treatment.

First POIS Research Study, 2002

We have a copy of the first formal medical investigation on POIS by Prof. dr. Marcel D. Waldinger,MD,PhD, and Dr. Dave Schweitzer, MD.

  
Recent POIS Research Study, 2010

CASE REPORT
Postorgasm Illness Syndrome - A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg316781#msg316781


British Medical Journal Case Report, 2010

Case study by Dr. Selwyn Dexter of a patient with a headache-featured POIS symptom treated with progesterone/norethisterone.
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short?rss=1


How to get any or all of the above 5 studies: send me or "daveman" a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and we'll send you back the PDF(s).

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around the recipient's name, i.e., "demografx", or "daveman".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the Journal of Sexual Medicine (Dr. Waldinger's study), British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For over 4 years, our POIS forum has attracted over 200 POIS sufferers worldwide who have posted here, research on an additional 200 sufferers elsewhere on the internet, plus over 1,300,000 page visits. Not bad for a rare malady!



SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: more than 4 years' worth of posts (over  10,000 posts!) from 200+ Forum members, and an additional 200 POIS sufferers found elsewhere on the Internet by Member B_Jim.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://thenakedscientists.com/

for example, I tried
nocturnal emission POIS site:http://thenakedscientists.com/

and 740 results came up for "nocturnal emission" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.

[Counterpoints]

Can anyone comment on the important differences between niacin and niacinamide?  I read on wikipedia that niacin, once ingested, is converted to niacinamide.  Niacinamide will not cause a flush, and has some other effects.  I read in a health food store that niacinamide helps with metabolism more than niacin, but I have not been able to find this information elsewhere.  I have not yet had time to take a good look at the wiki pages, but I am curious what people are taking here -- Niacin or Niacinamide?

[FinalPanic]

Hi all - long time since I have posted - but I do read on occasion. I have followed up an earlier post and have sent an email to Dr Goldmeier, I will let you know how I get on with this.

I seem to be suffering less - maybe only a day or two - it used to be several days. I do not know what has changed, but something has helped. I have given up smoking, alcohol (I used to do a lot of both), I eat a lot more fresh vegetables and less junk, I now also exercise regularly. I did try the Rellora thing for a while - it actually has helped me with underlying anxiety problems - it seems to have broken a vicious cycle in that respect. It is possible that a healthier lifestyle has improved my ability to cope, but as things are still not right I will see what response I get from Dr Goldmeier. All the best.

[daveman]

Yesterday took 2 x 500mg Niacin (on day 2) at 10pm.
Woke up at 3am with bad sunburn type effect, skin pain. Then woke in morning 7am feeling like I had 2/3 beers the night before.
Its not for me,
its the harshest food supplement ever. I think even smaller doses will be bad for my liver over time.

Pills, sunburn, hangover...like a night out in Ibiza without the fun.

Horizon, No WONDER you felt bad. 2x500mg is a horrendous dosage, especially for a first time.

Even 3x100 is a fair bit, but between that and 1000mg there's a tremendous difference.

Hope you are better. Please be careful!

[silverandcol]

Yesterday took 2 x 500mg Niacin (on day 2) at 10pm.
Woke up at 3am with bad sunburn type effect, skin pain. Then woke in morning 7am feeling like I had 2/3 beers the night before.
Its not for me,
its the harshest food supplement ever. I think even smaller doses will be bad for my liver over time.

Pills, sunburn, hangover...like a night out in Ibiza without the fun.

Horizon, No WONDER you felt bad. 2x500mg is a horrendous dosage, especially for a first time.

Even 3x100 is a fair bit, but between that and 1000mg there's a tremendous difference.

Hope you are better. Please be careful!

Yup, it is also not good for the body to take that much.  The xan-pro tablets I have only have 42mg of niacin and 150mg of XN.

[B_Daniel]

If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT  []

That's hilarious!  First of all, I'd love an I heart B3 or maybe even a B3 is my Homeboy t-shirt.  Second, it'd be a bit cruel to have Demo hang up a picture of a banned former-member of the forum.  Victor, do you have a cat??  Maybe a picture of Victor would be a good compromise!  []

[B_Daniel]

"4.      Supplement the form of niacin called inositol hexanicotinate.  It can cross the blood brain barrier more effectively than niacin.  It has no flush, while niacin has a flush.  Niacin can increase cell membrane permeability.  Increasing cell permeability can improve the ability of supplements to penetrate into cells.  Dr. Bob advised 100 mg of hexanicotinate in the AM along with methionine supplementation. "

Hey Quasar - welcome to the forum!  I think I'm the only one who's tried inositol hexanicotinate (IH).  I tried it once a couple weeks ago and had a positive result, but a one-time test on my crazy body doesn't mean a whole lot.  I will be starting a new job on Monday so I unfort can't afford to experiment right now.  And when I finally do start experimenting it'll be with XN first.  So I recommend somebody else buy some IH to try and give it a whirl - I don't want to keep everybody waiting on those results.... sorry

[victor.kons]

If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT  []

That's hilarious!  First of all, I'd love an I heart B3 or maybe even a B3 is my Homeboy t-shirt.  Second, it'd be a bit cruel to have Demo hang up a picture of a banned former-member of the forum.  Victor, do you have a cat??  Maybe a picture of Victor would be a good compromise!  []

I think you want the picture of Olga Vasil'evna Bruslenko. She has a CAT, this cat is very strange and she has even a dog, if you prefer dogs . But if seriously, this is her who was the first to come up with the idea that Niacin should help to get rid of POIS symptoms, not me, and of course not Dmitriy. Dmitriy found out this from me, we still have periodical chats with Dmitriy.

Victor

[CertainlyPOIS]

If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT  []

That's hilarious!  First of all, I'd love an I heart B3 or maybe even a B3 is my Homeboy t-shirt.  Second, it'd be a bit cruel to have Demo hang up a picture of a banned former-member of the forum.  Victor, do you have a cat??  Maybe
a picture of Victor would be a good compromise!  []

I think you want the picture of Olga Vasil'evna Bruslenko. She has a CAT, this cat is very strange and she has even a dog, if you prefer dogs . But if seriously, this is her who was the first to come up with the idea that Niacin should help to get rid of POIS symptoms, not me, and of course not Dmitriy. Dmitriy found out this from me, we still have periodical chats with Dmitriy.

Victor

Did she ever explain why she thinks XN will work she is the doctor she prolly has the best theory.

[demografx]

If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT  []

That's hilarious!  First of all, I'd love an I heart B3 or maybe even a B3 is my Homeboy t-shirt.  Second, it'd be a bit cruel to have Demo hang up a picture of a banned former-member of the forum.  Victor, do you have a cat??  Maybe a picture of Victor would be a good compromise!  []

Unfortunately, due to forum space considerations, I had to merge the two (sorry).

[B_Daniel]

haha lol!

[B_Daniel]

Did she ever explain why she thinks XN will work she is the doctor she prolly has the best theory.

CCconfucius, I'm just echo-ing / adding on to your question above

Victor - Does Dr. Bruslenko speak English? 

It would be interesting to get a more detailed explanation from her of how she arrived at her Niacin theory, and also, given that she hit the nail on the head, perhaps she has her own theory on exactly WHAT pois is.  I'm especially blown away by the timing of her diagnosis with you - because she recommended Niacin to you even BEFORE Dr. Waldinger's auto-immune theory was published.  These were the 'dark ages' in my mind, when the leading theory on POIS was a hormone deficiency.  We've come a long way. 

Also, I wonder if she's read Dr. Waldinger's papers.  And I bet she'd be interested to learn that there's a forum of 300 people who suffer from POIS and a few of us are beginning to benefit from her treatment.  Perhaps even she'd be a candidate for the NORD research fund.

Have you seen her over the last few weeks and discussed any of these things with her yourself?  What is her specialty as well, I forgot what you told us

[demografx]

BD, yes, I agree, it would be terrific to learn more from Dr. Bruslenko and to invite her participation.

edit - strangely, in Google when searching for  "Bruslenko medical", I only find one obscure cardiology footnote for NS Bruslenko, but without matching Olga, etc.

[victor.kons]

BD, yes, I agree, it would be terrific to learn more from Dr. Bruslenko and to invite her participation.

edit - strangely, in Google when searching for  "Bruslenko medical", I only find one obscure cardiology footnote for NS Bruslenko, but without matching Olga, etc.

You will not find her on Internet. She is an old-school doctor.

Victor

[Quasar]

@demografx, thanks a lot for the welcome to this forum.

I searched the internet for the niacin form "inositol hexanicotinate" but it seems it is not as effective as standard niacin.

Besides this, i have a question for you,

Has anyone thought about a virus?

I say this because i have chronic Epstein Barr virus (as many people) and also Herpes virus.

Maybe we all have energy issues, like Chronic Fatigue Syndrome. And when we have sex or masturbation, our energy levels sink, so our defenses become lower. Then we feel tired, and resident virus become more powerful until we recover.

I remember before having an Herpes Zoster i had less energy isssues.

[Willem]

Besides this, i have a question for you,

Has anyone thought about a virus?

I say this because i have chronic Epstein Barr virus (as many people) and also Herpes virus.

Maybe we all have energy issues, like Chronic Fatigue Syndrome. And when we have sex or masturbation, our energy levels sink, so our defenses become lower. Then we feel tired, and resident virus become more powerful until we recover.

I remember before having an Herpes Zoster i had less energy isssues.

Yes, the idea has been discussed a number of times.  As you're probably aware, Dr. Waldinger's paper hypothesizes a semen allergy autoimmune response.  One of the first things you should do is try to confirm if you're allergic.  You can get a subcutaneous or skin ***** test by an allergist (if you can find an open minded one willing to use your semen). 

For those of us that have a confirmed POIS-like reaction to just semen it helps focus the search for treatments.  Of course, autoimmune may not be the only cause of POIS, it's just one that's easy to test for. 

[Quasar]

Besides this, i have a question for you,

Has anyone thought about a virus?

I say this because i have chronic Epstein Barr virus (as many people) and also Herpes virus.

Maybe we all have energy issues, like Chronic Fatigue Syndrome. And when we have sex or masturbation, our energy levels sink, so our defenses become lower. Then we feel tired, and resident virus become more powerful until we recover.

I remember before having an Herpes Zoster i had less energy isssues.

Yes, the idea has been discussed a number of times.  As you're probably aware, Dr. Waldinger's paper hypothesizes a semen allergy autoimmune response.  One of the first things you should do is try to confirm if you're allergic.  You can get a subcutaneous or skin ***** test by an allergist (if you can find an open minded one willing to use your semen). 

For those of us that have a confirmed POIS-like reaction to just semen it helps focus the search for treatments.  Of course, autoimmune may not be the only cause of POIS, it's just one that's easy to test for. 

Thanks Willem for the answer. Yeah, i was aware of the autoinmune theory by Dr. Waldinger. But it's not the same theory. Chronic Fatigue Syndrome caused by Herpes / Epstein Barr, is a different theory. It could be that because POIS sufferers have energy issues (Chronic Fatigue), when we have sex we have even more energy issues.

I think it could be interesting to get checked for Epstein barr, and other Herpes virus. I think there are special tests for chronic Epstein Barr. And one line of treatment are antivirals.

About getting a skin ***** test by an allergist of my semen...i think i am too shy to tell my allergist: "hey, i think i have Pois (this already would be embarrasing), can you please do a skin ***** test with my semen?  [:-[]

[Habibou]

Put your shame in a bag and ask it (as I did and many others !)  [] it could make your shape better soon, do not miss this opportunity...