[demografx]

<former Moderator visiting periodically>

Hi friends, I am back. Started new theraphy from next week to find cure to POIS.  Will post on this soon

Welcome back, Nathan!

 []

[demografx]

<former Moderator visiting periodically>

This is a horrible illness and I hope a cure will be found.

Excellent summation, Tired!

[Tired of this]

Thanks Demo.
I've spent many hours reading as much as I can about POIS the last couple of days, especially about experiences of fellow POIS sufferers. I'm very motivated to fight this illness as much as I can. I've learned about a couple of supplements/vitamins to reduce the symptoms of POIS and I'm going to try a couple of them out, all in a safe way of course. If I find something that works for me I will write about it here.

[desperate man]

Excuse me if this question has been asked before, but I must know: Niacin helps some people with POIS, but do we have Niacin deficiency or is it just the flush that helps relieve alleviate some of the symptoms?
Someone I know (non-POIS sufferer) came back with lab tests from the doc. It showed severe niacin deficiency so I thought I would ask.

[fornicationDENIED2]

I had a POIS relapse, and also other symptoms like chronic insomnia, etc.

It turns out that the opiates I took to manage the pain from tonsil removal on a 4 day period elevated my damn prolactin again. I should have known this would happen.

Newest blood test shows this: Prolactin......9.06 NG/mL range for males (<=10)

Inside the stupid range yet feeling like my world is collapsing anyway. I need to get dopamine agonist prescription, yet I am scared if 2 or 3 weeks of usage which is probably all I will ever need will cause withdrawal syndrome, there is no information about short term usage side effects regarding withdrawal that I am aware of and it drives me insane.

I also may need an excuse if my levels are not high enough for qualifying for hyperprolactemia treatment, could social anxiety be a valid excuse (This is something I actually have to some degree thanks to POIS mainly)  or any other mental condition?

[desperate man]

I had a POIS relapse, and also other symptoms like chronic insomnia, etc.

It turns out that the opiates I took to manage the pain from tonsil removal on a 4 day period elevated my damn prolactin again. I should have known this would happen.

Newest blood test shows this: Prolactin......9.06 NG/mL range for males (<=10)

Inside the stupid range yet feeling like my world is collapsing anyway. I need to get dopamine agonist prescription, yet I am scared if 2 or 3 weeks of usage which is probably all I will ever need will cause withdrawal syndrome, there is no information about short term usage side effects regarding withdrawal that I am aware of and it drives me insane.

I also may need an excuse if my levels are not high enough for qualifying for hyperprolactemia treatment, could social anxiety be a valid excuse (This is something I actually have to some degree thanks to POIS mainly)  or any other mental condition?

Questions to you: Have you ever been on antidepressants? Have you ever tried dopaminergic supplements (maca, B vitamins, certain amino acids)? How does your current diet look like? What other lab tests do you have?

People need to post lab tests because then we might pinpoint something crucial. I'm sure OP would not mind as it would support the research us non-medical, depressed beings do.

[Tired of this]

Ok so I tried Niacin for the first time yesterday. After reading a lot about it I decided to test it out and see for myself. I bought the flush type 100mg. I had not eaten for four hours before taking it. Took the pill at 5:30 pm and felt nothing till 6pm so I decided to take another one. Within 5 minutes my body started to tingle and after 15  minutes my face was as red like a tomato. I don't know if this was the effect of the first or second pill but it was definitely working. At around 6:35 pm I had an orgasm. At first I didn't know if this was too soon since it was about 20 minutes after the flush really started but I could feel the flush going away and my face was still a bit red when I orgasmed. Next time I try to be a bit more patient and orgasm 45 minutes after the flush.

Anyways, immediately after the orgasm I noticed that I wasn't sleepy like I normal am after an orgasm. I just got up and cleaned myself. I didn't really feel a drop in energy as well like is normally the case.
So almost no difference before and after orgasm. One thing I did notice was that I was very tired very soon in the evening. Went to sleep at 9:30 pm already and slept for ten hours.

The flush was really strong so maybe that took a lot of energy from my body? I felt very energized the first two hours after taking the Niacine but then became tired.

Today I don't feel the symptoms as strong as I would without Niacine. It's hard to measure but I would say the symptoms reduced 60 to 70%. It's still early so I don't know what the rest of the day will bring, also day 2 is normally my worst day after an orgasm so we have to see how that goes. But until now I would describe my experience with Niacin as positive

[Mer]

I suggest trying to understand why we have excess parasympathetic responses after orgasm?? that lasts for a week? Trying to understand from the first principles.

[Water]

Hi Mer, I think you are right. I am a nurse (44) suffer from POIS sice 25 years (pain, brain fog ect...) and I searched much to find deeply the cause of the problem. I meet soon my urologue to treat DEFINITIVELY (I hope!) the problem. Here is what I think what is POIS: This would be (for me, I specify!), a microadenoma to the epididym. Microadenomas releases catecholamins (sometimes, not always) and when the O. occurs, the hormonal system that is informed of the O. doesn't recognise the presence of cathecolamines in the parasympatic chain and an allergy occurs (the oedema and pain) and systemics problems occurs also as dominos...
Concretely: I can feel the microadenoma that is a kyst of 3 mm with palpation at the left testicule. For me it is only one side but there is a risk that microadenomas are on both sides. An echoghrapy will confirm the diagnosis, and after I will take an appointement in surgery, the operation is of a small importance (I'm not there, but I so hope I'm not wrong). I will write soon to confirm the results.

[desperate man]

Been reading about the issue I'm dealing with on top of all this (which is teeth clenching while I sleep). It was induced by antipsychotic drugs. I just read a study how they treated people with this condition by supplementing with L-Dopa. One natural source of this chemical is Mucuna pruriens. How is your experience with this?

WARNING: Unnatural sources of L-Dopa can cause permanent heart damage. Always use google before you give yourself in to try a new supp/drug!

Edit: Some claim "Without green tea, Mucuna is more of an anti-prolactin agent (prolactin is what causes the feeling of a sexual hangover)." Be cautious with herbs! Although we might have elevated prolactin due to the reaction of POIS or whatever else. Problem is we still just theorize the possible causes and chemical reactions. If your prolactin is elevated temporarily by POIS, then during these times Mucuna could help alleviate these symptoms. Problem is if you tend to drop your prolactin below healthy human levels then over-stimulation occurs. In the end this is going to cause the heart problems. If you have used L-Dopa or Mucuna (w or w/o green tea) then please share your experience because this could be a remedy for those of us with depression, PTSD and anhedonia on top of POIS!

[ozmoses]

I'm a newbie to this forum and was reading the older posts and decided to start reading the most recent ones.  I had read a paper/study that concluded that prolactin increase was the norm post orgasm and it occurred to me that perhaps many of us POISers may simply have a longer period during which prolactin is heightened in our systems. 

I have tried the flushing niacin, aspirin, antihistimine combinations with limited results.  If Mucuna is likely to drop prolactin levels, then it would be a good thing to try.  I wonder if taking it right before sexual activity and after would be of value.  Given any of the concerns you've expressed, perhaps starting with a low dose would be advisable.  Also, would Ashwaganda or Maca potentially have a prolactin inhibiting quality?   

[ozmoses]

Poisers may have a sudden fall in dopamine after an orgasm...symptoms says.

Everyone gets a sudden decrease in dopamine thanks to the temporal increase in prolactin after ejaculation. When you really think about it, hyperprolactemia could in theory cause similar symptoms to POIS

Talking about prolactin, I managed to reduce it from 11.66 ng/mL to 4.03 ng/mL and I have experienced progress because  of this.I could say I am almost cured, there are still things I must do like updated thyroid bloodwork and see it that was fixed and some  insomnia  I get if I ejaculate at night which I can't explain yet, better than POIS but still...

fornication, that's great that your prolactin levels have dropped. It would be useful for you to share how you managed to do that. Thanks.

[ozmoses]

Here's a short, but useful summary of some natural prolactin inhibitor supplements.  I'm sure that some of you have tried a variety of these.  I'm going to check some of them out.  I do have pyroluria, so my b6/zinc intake needs to increase. 

http://www.muscle-health-fitness.com/prolactin-inhibitor.html/ [nofollow]

[ozmoses]

Can anyone recommend a reputable lab where I can order a prolactin, progesterone and other relevant tests online?

[desperate man]

Hi ozmoses and welcome!

You are right on time. I drifted my focus on B6 as well after reading that nearly all amino acids require B6. Common myth is that B6 deficiency equals serotonin deficiency. In reality B6 is needed for both dopamine and serotonin. Remember that when your prolactin shoots up your dopamine will fall. Vice versa. Been part of Pyroluria group, but haven't experimented with high doses of B6 before. All symptoms match. Over a year ago I had a health test done by a dubious practitioner and results came back with deficiency of B6 that was the most significant of all my deficiencies. No other vitamin came up besides B6.  This vitamin is so essential that it's needed for 19 out of 20 amino acids in your body and you will not find the exact same list symptoms of it's deficiency on different websites. Guaranteed. Deficiency will mimic all kinds of things you can imagine. Just one particular amino acid (too low/too high levels) can f*** you up for good then there's the neuotransmitter imbalance and psychological issues. Then there's the physical issues resulting from the chemical imbalance. Meanwhile you're using up more and more B6 because you are in a constant state of stress. It's a viscious cycle. I'm planning to do 10000% RDA of B6 and titrate it down from there. Will let you know how it goes.
Wishing you success with Pyrrole disorder! It's a b**** I know this from a personal point of view.

Significance of B6: https://www.e-tyh.com/cscart/Health_Library_PDFs/BewareofB6-2011_L.pdf

edit: Did I mention the growth hormone deficiency (which does cause hypoglycemia by the way) that will result from melatonin deficiency due to lack of B6?  []
One of the main features of B6 deficiency is "seborrhoeic dermatitis-like eruption" which I've been dealing with for a long time now. Here's a pic of what this is: http://en.wikipedia.org/wiki/Seborrhoeic_dermatitis#mediaviewer/File:Seborrhoeic_dermatitis_highres.jpg

It's such a relief to know that there's another person suffering with both Pyroluria and POIS. Don't get me wrong! I felt so alone in this sh1t.  [:-'(] PTSD brings on Pyroluria. This happens usually in adolescent times. I know that since my PTSD I stopped remembering my dreams (which is one of the characteristics of this disorder). Hope you get better!

[johanstefansson]

LAPOISSE2 - if I were to try your method of letting go within some months i would loose my family, reputation and income and wealth. I seriously don't recommend anyone to have unlimited orgasms.

Until some years ago when i discovered POIS i did let go and it was terrible.

[johanstefansson]

Concretely: I can feel the microadenoma that is a kyst of 3 mm with palpation at the left testicule. For me it is only one side but there is a risk that microadenomas are on both sides. An echoghrapy will confirm the diagnosis, and after I will take an appointement in surgery, the operation is of a small importance (I'm not there, but I so hope I'm not wrong). I will write soon to confirm the results.

A nurse with POIS is exactly what we need. I pray for your success!

[ozmoses]

Hi ozmoses and welcome!

You are right on time. I drifted my focus on B6 as well after reading that nearly all amino acids require B6. Common myth is that B6 deficiency equals serotonin deficiency. In reality B6 is needed for both dopamine and serotonin. Remember that when your prolactin shoots up your dopamine will fall. Vice versa. Been part of Pyroluria group, but haven't experimented with high doses of B6 before. All symptoms match. Over a year ago I had a health test done by a dubious practitioner and results came back with deficiency of B6 that was the most significant of all my deficiencies. No other vitamin came up besides B6.  This vitamin is so essential that it's needed for 19 out of 20 amino acids in your body and you will not find the exact same list symptoms of it's deficiency on different websites. Guaranteed. Deficiency will mimic all kinds of things you can imagine. Just one particular amino acid (too low/too high levels) can f*** you up for good then there's the neuotransmitter imbalance and psychological issues. Then there's the physical issues resulting from the chemical imbalance. Meanwhile you're using up more and more B6 because you are in a constant state of stress. It's a viscious cycle. I'm planning to do 10000% RDA of B6 and titrate it down from there. Will let you know how it goes.
Wishing you success with Pyrrole disorder! It's a b**** I know this from a personal point of view.

Significance of B6: https://www.e-tyh.com/cscart/Health_Library_PDFs/BewareofB6-2011_L.pdf [nofollow]

edit: Did I mention the growth hormone deficiency (which does cause hypoglycemia by the way) that will result from melatonin deficiency due to lack of B6?  []
One of the main features of B6 deficiency is "seborrhoeic dermatitis-like eruption" which I've been dealing with for a long time now. Here's a pic of what this is: http://en.wikipedia.org/wiki/Seborrhoeic_dermatitis#mediaviewer/File:Seborrhoeic_dermatitis_highres.jpg [nofollow]

It's such a relief to know that there's another person suffering with both Pyroluria and POIS. Don't get me wrong! I felt so alone in this sh1t.  [:-'(] PTSD brings on Pyroluria. This happens usually in adolescent times. I know that since my PTSD I stopped remembering my dreams (which is one of the characteristics of this disorder). Hope you get better!

Thanks for the reply.  Did you actually get tested for pyroluria? I did and have begun a zinc, b6, p5p regimen, but also higher doses of Omega 3s amongst a boat load of other supps.  Just literally went in to get my prolactin and progesterone levels tested this morning along with casein and gluten since I seem to have some annoying food allergies/intolerances as well. Fingers crossed on results.

If my prolactin levels are high enough, I'm going to find a doctor who will prescribe CABERGOLINE for me.  Has anyone here tried it and found benefit?  I'll try to go through this forum and find info on that, but dang, there are an enormous number of posts. 

Apparently, SSRIs are one of the biggest causes of high prolactin levels in men.  I was taking celexa for the past 10 years and then finally decided that I had enough.  The withdrawals from getting off that evil med were the worst I've ever experienced in my life.  BIG PHARMA and the FDA should be prosecuted for allowing such damaging medications to be on the market.  Evil frackers.

Anyways,  POIS is real and debilitating in a life altering way.. big way.  I may post on my issues just for the record one of these days. 

If I see any benefits from any protocol that I'm on, I will certainly spread the word.  No one should have to deal with this bulls*$t from something that is so normal and so enjoyable. Sex should not cause depression, extended fatigue, lack of motivation etc.  In our hypersexual society, it's hard to stop once you've started.  BTW, I've never been into porn so that hasn't been an issue. More the soft core stuff or simply lingerie/swimsuit model types.  Gotta leave a little to the imagination IMHO.    Anyways, signing off for now.  But checking in again soon.  LET'S ALL FIGURE THIS OUT AND ELIMINATE THIS POIS'ON FROM OUR LIVES!!!!!!!  HEEYAH

[ozmoses]

<former Moderator visiting periodically>

Hello peoples.

I have returned with a small bit of useful info.

I have found a new regiment thats really helped me stave off unwanted nocturnal emissions.

I consume one Monster Energy Java drink a day. Thats it. Now how does this work? Not sure why this particular energy drink is so potent, but it seems to noticeably "desensitize" one as well as lower the sexual urge. I used to use dream control and take a muscle relaxer etc etc. For whatever reason though drinkin one of those Monster Java energy drinks a day has made avoiding NE's so much easier. Im not gonna even begin to dissect the reason, I just know that it works fairly well. Also relieves minor aches and pains, this particular brand of energy drink, so might be helpful for those who have O'ed as well? Anyways, fight the good fight. Im out. Peace.

Monster drinks have 400% more caffeine than same size Starbucks.

Many of the people facing POIS in all likelihood also have adrenal fatigue.  I have adrenal fatigue.  When I've had caffeine (like an ice mocha, anything coffee related or chocolate) I get ridiculous levels of fatigue and sweat alot more.  I would highly advise many of you to NOT consume caffeine if you find that it causes problems for you.   For those who get benefit from it, congrats, but I would just proceed with caution.  It likely is a poor short term solution for many.

[ozmoses]

For those of you familiar with MTHFR and other genetic mutations, have any of you figured out which mutations might be responsible for POIS?

I have a wide mix of snps that are undoubtedly causing alot of my problems, but haven't really found an expert to help me consolidate the data. 

Any thoughts would be awesome.