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They do something that's for sure. Typically, they bind neuronal receptors, such as serotonergic or dopaminergic, in your brain quite strongly. So strongly that the receptor protein does not unbind from the drug and this leads to various biological effects on the neuron such as decreased or increased activity and potentially cell death, or cell growth in some cases.If you need a life change, antipsychotics will probably do that for you because they'll change your brain. More likely for the worse from what I gather, but there could be some good too.
Quote from: Villi on 15/06/2016 08:20:35They do something that's for sure. Typically, they bind neuronal receptors, such as serotonergic or dopaminergic, in your brain quite strongly. So strongly that the receptor protein does not unbind from the drug and this leads to various biological effects on the neuron such as decreased or increased activity and potentially cell death, or cell growth in some cases.If you need a life change, antipsychotics will probably do that for you because they'll change your brain. More likely for the worse from what I gather, but there could be some good too.Thanks, Villi. I guess long-term antipsychotics use may induce dopamine hypersensitivity and mesolimbic neuronal damage. Thus, drug-induced schizophrenia is perhaps the result of antipsychotics binding to dopaminergic neurons.
Aripiprazole subgroup displayed significant increases in bilateral hippocampal volume compared with all other subgroups.
There are no objective tests in psychiatry-no X-ray, laboratory, or exam finding that says definitively that someone does or does not have a mental disorder.” “It’s bull—. I mean, you just can’t define it.” — Allen Frances, Psychiatrist and former DSM-IV Task Force Chairman
Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes. It remains controversial whether the defects are treatment induced or disease related. Although the mechanisms underlying these metabolic defects are not understood, it is assumed that the initiating pathophysiology is weight gain, secondary to centrally mediated increases in appetite. To determine if the AAPs have detrimental metabolic effects independent of weight gain or psychiatric disease, we administered olanzapine, aripiprazole, or placebo for 9 days to healthy subjects (n = 10, each group) under controlled in-patient conditions while maintaining activity levels. Prior to and after the interventions, we conducted a meal challenge and a euglycemic-hyperinsulinemic clamp to evaluate insulin sensitivity and glucose disposal. We found that olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones. Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease, suggesting that AAPs exert direct effects on tissues independent of mechanisms regulating eating behavior.
Q . Do atypical antipsychotics really work?
... I came to the conclusion that schizophrenia is a fake disorder pushed by psychiatry to medicate people based on pseudoscientific voodoo.
I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.
Quote from: tkadm30 on 17/06/2016 11:20:51I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.A biological test like a blood test?
Quote from: Villi on 18/06/2016 17:35:25Quote from: tkadm30 on 17/06/2016 11:20:51I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.A biological test like a blood test?Yes, a blood test would be a excellent diagnostic, assuming schizophrenia could be detected in the blood.sznews/archives/001395.html
Thanks for the link.I read about blood tests for bipolar and suicidal ideation but never came across this work for schizophrenia. This is a bit scary because more often than not, people are medicated straight away at any hints of psychiatric disorders. Therefore a blood test, and it's development, are skewed by the fact that there are almost no people with schizophrenia who are unmedicated to compare to with the 100% of people with schizophrenia who are/have been medicated.I think you could detect "schizophrenia" in blood, but that is not really useful and is probably dangerous. Just my thoughts.
It is fairly uncommon for a patient who is sick enough to need antipsychotic medication to have enough insight to understand that he or she needs them. Personal anecdotal accounts don't carry much weight therefore.A good way to check their efficacy is to ask the family members, who must live with the patient, whether they work or not.Living with a person who suffers from a chronic mental disorder can be remarkably tedious --- and some times dangerous -- if and when they are cheeking their medications.
drug-induced schizophrenia
Quote from: tkadm30drug-induced schizophreniaLong term cannabis use is thought to trigger schizophrenia in some individuals.Maybe one drug is needed to counteract the side-effects of a previous drug?
Marijuana use will not create symptoms of mental disorders as it doesn't alter brain intrinsic activity.