[snorkfort]

Your use of the term "mainstream media" is absolutely ridiculous. This indicates you know nothing about the diversity in the media.

Please tell me about the so-called "diversity in the media", because so far my experience on internet forums like this one made me learned the true meaning of "mainstream media": It is the absence of diversity in the media which is problematic, not the opposite. Your use of the term "conspiracy theory" is evidence you belong into the msm camp.

You cannot argue against the accepted meanings of words. The term "conspiracy theory" nowadays has negative connotations. This is a fact that neither I, nor you, can change. What is wrong with your thinking ability?

[snorkfort]

Well nearly every conspiracy theory has COME TRUE.

Name a few.
Here are plenty to choose from.
https://en.wikipedia.org/wiki/List_of_conspiracy_theories

The phrase "conspiracy theorist" is a derogatory smear phrase thrown at someone in an attempt to paint them as a lunatic. It's a tactic frequently used by modern-day thought police in a desperate attempt to demand "Don't go there!"

The term "conspiracy theorist" is rightly used in this context to describe a wacky allegation of a conspiracy with no credible evidence supporting it. The OP is naively alleging there is a conspiracy between pharma companies and regulatory authorities to sell ineffective unsafe chemotherapy drugs which cause cancer. This is a mad conspiracy theory. There is no evidence supporting this. In reality, tens of thousands of hardworking, intelligent, honest scientists, engineers, and physicians have been working diligently for decades to design chemotherapy drugs to be as effective, safe and precisely targeted as is humanly possible. Please stop wasting our time with your nonsense. Googling conspiracy theories is NOT research.

[profound (OP)]

Here is a little conspiracy theory for you.

We will wait and see your positive spin on it:-

I'm still waiting for you to explain why you claim that Big Pharma (who, I accept are frequently immoral ad corrupt)  are in any way denying something by including it in their product description.

Your original post never made sense, and it still doesn't.

It may have escaped your notice, but weedkiller isn't a pharmaceutical.

You also seem to have ignored the fact that quite a lot of stuff you have posted simply wasn't true, or was just stuff you made up.
When you answer those you will be in a reasonable position to start asking more questions.
That's the way debates happen.

Weed killer goes into you when you ingest food.You seem to be unaware of that.
What did I make up?

Anyway Big Pharma has conspired with doctors to get the nation hooked on opiods and 142 are dying every day.

As I said terrorism is the least cause of death and Big Pharma and doctors the biggest.

 President Donald Trump has declared the opioid epidemic a "national emergency," but what happens now, and could this declaration really help address the crisis?

On Thursday (Aug. 10), Trump told reporters that the opioid epidemic is a national emergency. "We're going to spend a lot of time, a lot of effort and a lot of money on the opioid crisis," he said.

https://www.livescience.com/60119-opioid-crisis-national-emergency.html?utm_source=ls-newsletter&utm_medium=email&utm_campaign=20170814-ls

     

Opioid Crisis Is a 'National Emergency': What Happens Now?
Credit: Steve Heap/Shutterstock

President Donald Trump has declared the opioid epidemic a "national emergency," but what happens now, and could this declaration really help address the crisis?

On Thursday (Aug. 10), Trump told reporters that the opioid epidemic is a national emergency. "We're going to spend a lot of time, a lot of effort and a lot of money on the opioid crisis," he said.

In a statement, the White House said Trump had " instructed his administration to use all appropriate emergency and other authorities to respond to the crisis caused by the opioid epidemic."

The declaration follows a recommendation from "Trump's commission on the opioid crisis" (PDF report), which urged the president to declare a national emergency over the issue.

The report says more then 560000 Americans died from 1999 to 2015 due to prescription drugs.

According to the Centers for Disease Control (CDC), the most recent data estimates that 142
Americans die every day from a drug overdose. Our citizens are dying. We must act boldly to
stop it. The opioid epidemic we are facing is unparalleled. The average American would likely
be shocked to know that drug overdoses now kill more people than gun homicides and car
crashes combined. In fact, between 1999 and 2015, more than 560,000 people in this country
died due to drug overdoses – this is a death toll larger than the entire population of Atlanta. As
we have all seen, opioids are a prime contributor to our addiction and overdose crisis. In 2015,
nearly two-thirds of drug overdoses were linked to opioids like Percocet, OxyContin, heroin,
and fentanyl. This is an epidemic that all Americans face because here is the grim reality:
Americans consume more opioids than any other country in the world. In fact, in 2015, the
amount of opioids prescribed in the U.S. was enough for every American to be medicated
around the clock for three weeks.
Since 1999, the number of opioid overdoses in America have quadrupled according to the CDC.
Not coincidentally, in that same period, the amount of prescription opioids in America have
quadrupled as well. This massive increase in prescribing has occurred despite the fact that
there has not been an overall change in the amount of pain Americans have reported in that
time period. We have an enormous problem that is often not beginning on street corners; it is
starting in doctor’s offices and hospitals in every state in our nation....

[profound (OP)]

Your use of the term "mainstream media" is absolutely ridiculous. This indicates you know nothing about the diversity in the media.

Please tell me about the so-called "diversity in the media", because so far my experience on internet forums like this one made me learned the true meaning of "mainstream media": It is the absence of diversity in the media which is problematic, not the opposite. Your use of the term "conspiracy theory" is evidence you belong into the msm camp.

The MSM is controlled through a combination of advertising revenue and relationships forged simply to keep bad things of the perpetrators of the front page.

Note how a few people killed through a terrorists act gets vasts amounts of wall to wall publicity but Big Pharma corruption and the huge number deaths never do.Big Pharma has trillion $ profits and that vast wealth is used to control politicians,media,regulatory bodies,advertising to brainwash you...

[exothermic]

Would you care to explain me how a naturally-derived DNA methyltransferase inhibitor may have profound pharmacokinetic limitations?

You should read up on elementary pharmacokinetics if you're going to continue this. Curcumin has been notoriously documented as having horrible bioavailability.

"Unfortunately, this compound evidences different problems for its application, such as low-aqueous solubility, rapid systemic clearance, inadequate tissue absorption and degradation at alkaline pH values. As a consequence, its oral bioavailability is extremely poor and CUR can be classified as a class IV compound in the BCS system (Wahlang et al., 2011). Furthermore, the drug is rapidly photodegraded by light, also limiting its clinical use (Cañamares et al., 2006; Kumavat et al., 2016)."

The nanoemulsions definitely show promise.... but once again.... curcumin isn't currently used as a first-line anti-oncogenic due to its profound pharmacokinetic limitations.

~

[Kryptid]

I wonder how many doctors, pharmacists and medical chemists who have developed cancer have willingly undergone chemotherapy...

[Bored chemist]

I wonder how many doctors, pharmacists and medical chemists who have developed cancer have willingly undergone chemotherapy...

Well, My mum had chemotherapy and radiotherapy. My best guess is that it gave her another 5 years or so, during which she was able to travel the world and visit (among others) her sister in Africa.
She's not a doctor, pharmacist or whatever.
But she did ask me about it and I recommended that she went with the therapy.
I'm a pharmaceutical chemist by qualification, but I actually work in a totally unrelated field (which doesn't like me to mention it on social media).
So, I'm qualified and unbiased and I'd recommend to  those in need.

It's shitty- but it's slightly less shitty than being dead.

[smart]

The nanoemulsions definitely show promise.... but once again.... curcumin isn't currently used as a first-line anti-oncogenic due to its profound pharmacokinetic limitations.

I googled for "curcumin pharmacokinetics" and found the following study:

Adv Exp Med Biol. 2007;595:453-70.
Pharmacokinetics and pharmacodynamics of curcumin.
Sharma RA1, Steward WP, Gescher AJ.
Abstract
"Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2-8% of most turmeric preparations. Preclinical data from animal models and phase I clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing. Efficient first-pass metabolism and some degree of intestinal metabolism, particularly glucuronidation and sulfation of curcumin, might explain its poor systemic availability when administered via the oral route. A daily oral dose of 3.6 g of curcumin is compatible with detectable levels of the parent compound in colorectal tissue from patients with cancer. The levels demonstrated might be sufficient to exert pharmacological activity. There appears to be negligible distribution of the parent drug to hepatic tissue or other tissues beyond the gastrointestinal tract. Curcumin possesses wide-ranging anti-inflammatory and anticancer properties. Many of these biological activities can be attributed to its potent antioxidant capacity at neutral and acidic pH, its inhibition of cell signaling pathways at multiple levels, its diverse effects on cellular enzymes, and its effects on cell adhesion and angiogenesis. In particular, curcumin's ability to alter gene transcription and induce apoptosis in preclinical models advocates its potential utility in cancer chemoprevention and chemotherapy. With regard to considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat or prevent human diseases, curcumin is currently a leading agent."

My guess is that you should not underestimate curcumin anticancer properties simply because of its low oral bioavailability. You can overcome its low bioavailability by switching to phytosomal (phosphatidylcholine) curcumin formulations: https://www.ncbi.nlm.nih.gov/pubmed/27503249?dopt=Abstract

[exothermic]

Adv Exp Med Biol. 2007;595:453-70.
Pharmacokinetics and pharmacodynamics of curcumin.
Sharma RA1, Steward WP, Gescher AJ.
Abstract
"Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2-8% of most turmeric preparations. Preclinical data from animal models and phase I clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing. Efficient first-pass metabolism and some degree of intestinal metabolism, particularly glucuronidation and sulfation of curcumin, might explain its poor systemic availability when administered via the oral route. A daily oral dose of 3.6 g of curcumin is compatible with detectable levels of the parent compound in colorectal tissue from patients with cancer. The levels demonstrated might be sufficient to exert pharmacological activity. There appears to be negligible distribution of the parent drug to hepatic tissue or other tissues beyond the gastrointestinal tract. Curcumin possesses wide-ranging anti-inflammatory and anticancer properties. Many of these biological activities can be attributed to its potent antioxidant capacity at neutral and acidic pH, its inhibition of cell signaling pathways at multiple levels, its diverse effects on cellular enzymes, and its effects on cell adhesion and angiogenesis. In particular, curcumin's ability to alter gene transcription and induce apoptosis in preclinical models advocates its potential utility in cancer chemoprevention and chemotherapy. With regard to considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat or prevent human diseases, curcumin is currently a leading agent."

...

As far as cancer is concerned, in vitro studies have demonstrated  that cancer cells do not die unless they are exposed to curcumin concentrations of 5–50 lM for several hours. 4,9,10

Because of its poor bioavailability, these concentrations are not achieved outside the gastrointestinal tract when curcumin is taken orally. Because of its extensive metabolism in intestine and liver, these concentrations cannot be maintained for several hours in the gastrointestinal tract.

This suggests that the chemotherapeutic potential of oral curcumin is limited even for the treatment of cancers of the gastrointestinal tract.

Accordingly, when 15 patients with advanced colorectal cancer were treated with curcumin at daily doses of 3.6 g for up to 4 months, no partial responses to treatment or decreases in tumor markers were observed.11

As discussed before, the plasma concentrations of curcumin in people taking relatively high oral doses of curcumin are very low, typically in the nanomolar range.

This means that the oral administration of curcumin does not lead to cytotoxic concentrations outside the gastrointestinal tract.

Int J Cancer. 2010 Apr 1;126(7):1771-5. doi: 10.1002/ijc.24967.
The dark side of curcumin.
Burgos-Morón E, Calderón-Montaño JM, Salvador J, Robles A, López-Lázaro M

[exothermic]

You can overcome its low bioavailability

No, you can merely improve it's bioavailability - but not enough to utilize curcumin as a first-line anti-oncogenic.

~

[Bored chemist]

Here is a little conspiracy theory for you.

We will wait and see your positive spin on it:-

I'm still waiting for you to explain why you claim that Big Pharma (who, I accept are frequently immoral ad corrupt)  are in any way denying something by including it in their product description.

Your original post never made sense, and it still doesn't.

It may have escaped your notice, but weedkiller isn't a pharmaceutical.

You also seem to have ignored the fact that quite a lot of stuff you have posted simply wasn't true, or was just stuff you made up.
When you answer those you will be in a reasonable position to start asking more questions.
That's the way debates happen.

Weed killer goes into you when you ingest food.You seem to be unaware of that.
What did I make up?

Anyway Big Pharma has conspired with doctors to get the nation hooked on opiods and 142 are dying every day.

As I said terrorism is the least cause of death and Big Pharma and doctors the biggest.

 President Donald Trump has declared the opioid epidemic a "national emergency," but what happens now, and could this declaration really help address the crisis?

...

I pointed out some of the stuff you made up earlier.
You made up the idea that the police are dealing with conspiracy theories.
You made up the assertion that "People who get chemo die quicker and in more pain."

Most of the "opiod crisis" stuff is just rebadging the old (failed) "war on drugs".
it's a diversion from real problems.
You should probably realise that citing Trump as evidence is a rookie error. He's famous for knowing little and telling the truth about less.

If you want to protest about a drug, try alcohol.

Stop posting more dross, and try answering some of the points people have made- you know- try to defend what you said . Or are you admitting that it's indefensible and just throwing out more junk at random in the hope that some of it's true?

[exothermic]

You can overcome its low bioavailability by switching to phytosomal (phosphatidylcholine) curcumin formulations

Nanoemulsification is the most effective delivery system for oral curcumin thus far. Piperine is a good addition for some.

[Bored chemist]

My guess is that you should not underestimate curcumin anticancer properties simply because of its low oral bioavailability. You can overcome its low bioavailability by switching to phytosomal (phosphatidylcholine) curcumin formulations: https://www.ncbi.nlm.nih.gov/pubmed/27503249?dopt=Abstract

So, has the link between eating turmeric and cancer been ditched, or is someone trying to pretend that the Indian sub-continent is spicing food with "phytosomal (phosphatidylcholine) curcumin formulations:"?

You can't have it both ways.

[exothermic]

My guess is that you should not underestimate curcumin anticancer properties

I didn't underestimate anything.

You overestimated curcumin's anticancer properties. Plain & simple.

~