[ron123456 (OP)]

Hello
Near Infrared light is in the perfect therapeutic optical window into our body. A super pulsed laser close to 800-1000nm should penetrate 4-5cm's (at least?) and, in a MRI setup, may penetrate the entire body?

If UV curing (like in fibreglass) is used for 3D printing, then why can't we use near IR curing inside the body?

Let's fibreglass those damn tumours!!!

In the least, it will buy an affflicted person time to enjoy some prolonged remaining life. You don't even have to fibreglass the tumour, just either the respiratory enzymes (either PKM2's or PDK's active sites), ( I think ).... and scan it like an MRI scan to do the curing since the near IR should reach.

What are you curing to solidify these PKM or PDK activation sites especially deep into a tumour as chemo doesn't penetrate so far?....Well..... let's go with the nanoparticle thing since "NP can enter cells easily"...and then perhaps beyond deep into the interior of a tumor?....how about a drug coated with a PKM2 or PDK enzyme sensitive nanoparticle coating? What drug? ....well how about one that cures with near IR and solidifies the dam things. They can afterwards be removed to prevent the bacteria thing. Yes it's not a solution (metastasis) , but it may be a time expander (treatment) for those in desperate need.

Please assist!...I'm not sure how solidfying/removing the PKM2 or PDK enzyme helps? To my knowledge...no PKM2 then no proliferation of cancer cells....no PDK, then no pyruvate accumulation in the cytosol to increase ridiculous cancer ATP production (I think)/(but what about the PDH?).

Please assist
 Thx

[evan_au]

in a MRI setup

In what respect would it be like an MRI setup?
- With Radio-Frequency energy?
- With superconducting magnets?
- With a tunnel?

Or perhaps you mean that you could approach tumors from many directions to minimise impact on surrounding tissues (this is often done in radiotherapy).

just (target) the respiratory enzymes (either PKM2's or PDK's active sites)

These are proteins, which have a wide range of absorption frequencies in the IR range.
But so do many other proteins.
If there is a frequency to which the body is mostly transparent, then that is not a frequency that will interact with proteins.

I suspect that selectively targeting particular proteins in the body via IR light is beyond our current technology.

as chemo doesn't penetrate so far?

As I understand it, the major problem with chemotherapy is that it reaches too far.
It is usually injected in the arm, and goes to all areas of the body with a blood supply, including gut and hair cells.

It would be nice to have a chemotherapy that was targeted, and just attacked the tumor. Perhaps light activation of an anticancer drug could localise the effect of the drug?

[puppypower]

When you heat and cook meat, the proteins are denatured, which means the hydrogen bonds and other secondary bonds, break, changing protein properties. If you could locally cook a cancer, it will become scrambled eggs instead of a cancer. Proteins need to pack a very specific way for a cancer to work. Denaturation messes that up.

There is a trick for tenderizing tough meat. You cover the meat in Kosher salt. The purpose of the salt is to extract out the water in the meat, and replace some of internal water, with salt ions. After the salt covered meat sits for about an hour, you wash off the salt and the meat is more tender, but somewhat salty. The loss of water and the addition of salt changes the protein packing.

This suggest an another process to treat cancer. Potentially, we could pulse sand blast cancer with kosher salt and really mess the cancer's molecular hydrogen bonding structures, rendering the cancer moot. The sand blast pulse is to penetrate the cancer, so the salt is disposed inside. 

Take a fresh tumor and cover it on kosher salt and see what happens. Next, pulse blast it with salt so it breaks the outside skin and enters the cancer. We have just tenderized the cancer. We may need to help the kidneys process the extra salt, while we tenderize the cancer steak, before cooking with IR. We can use sodium 22 for a tracer.

A tough piece of cancer meat need a long slow cook to get tender. But a tenderized cancer steak only needs a few minutes in each side.

[ron123456 (OP)]

Hello
Yes, I wasn't too clear about it being like a MRI setup. It would only be like a MRI setup (or even like a catscan) in respect that the IR cure beam would scan the tumor in slices (no magnetism involved at all).
Yes, I was a bit too high on the wavelength for the near IR cure beam (should be 800-900nm) to prevent mid IR vibrational heating. These new wavelengths should be well within the therapeutic optical window. (skin heating at 1000nm).  I wasn't trying to use IR heat to denature an enzymes active site. I was actually trying to cure/epoxy the active site of PKM2 and/or PDK enzymes. The normal healthy surrounding cells should only have PKM1 and no PKM2 and only PDH and no PDK so the IR cure beam should not affect normal cells as the epoxy acting drug should only enter PKM2 and/or PDK via the enzyme sensitive nanoparticle coating.
I wasn't trying to use the near IR beam to interact with a protein but only to interact with the epoxy drug introduced into the tumor. Then those tumor enzymes PKM2 and PDK would have their active sites epoxied.
But I'm not sure really what the outcome will be.
Thx
 


 

[Bored chemist]

All of this is interesting but it misses a vital point.
If you could recognise the cancer, you can cut it out with a knife- unsubtle, but effective.
However the big problem is that cancer tissue generally strongly resembles healthy tissue.
Not only does that make it hard to tell where to put the scalpel, it makes it likely that healthy tissue will be destroyed by the IR, salt (kosher or not) or whatever.
The difficulty isn't that cancer cells are hard to kill, it's that they are hard to distinguish from the stuff you don't want to kill.

[RD]

It would be nice to have a chemotherapy that was targeted, and just attacked the tumor. Perhaps light activation of an anticancer drug could localise the effect of the drug?

Someone beat you to that ... https://en.wikipedia.org/wiki/Photodynamic_therapy

[evan_au]

Another big problem with cancer is that by the time it is recognized by the patient and doctors, it has often spread to many parts of the body (metastasized).

By that stage it is too late to locate all the scattered bits of cancer, cut out all the bits of cancer, or zap all the bits of cancer with radiation (or epoxy resin, cured with IR or not).

At this late stage, you are down to:
- Chemotherapy, which goes everywhere in the body, and blindly kills all fast-growing cells: well-established, for many cancer types
- Discovering a hormone (or some other chemical) that the cancer depends on, and blocking it in the whole body: well-established for a fraction of breast cancers
- Discovering the means by which the cancer is hiding from the immune system, and blocking that; in theory, this would allow the immune system to attack the cancer wherever it is hiding. This is on the bleeding edge of cancer therapy.
- Many other ways have been tried to get the immune system to attack cancers, so far without consistent results.
- Reading the DNA of the tumors in an individual. DNA-reading technology is well-developed. It's understanding the flood of data that is currently beyond us; we are rarely able to turn it into an effective therapy before the patient succumbs.

See: https://en.wikipedia.org/wiki/Metastasis#Management

[ron123456 (OP)]

Thank you....a lot of info to think dwell on.....will be in touch
https://nutritionaloncology.org/images/aerobicGlycolysis.jpg