[Petrochemicals (OP)]

Sinovac in action.

https://www.bbc.co.uk/news/world-latin-america-56731801

Does this mean it is ineffective entirely or just against the Brazil strain. Would producing a deactivated virus to the Brazilian strain be faster or can a Genetic engineered vaccine cover much more all in one.

[evan_au]

Would producing a deactivated virus to the Brazilian strain be faster or can a Genetic engineered vaccine cover much more all in one.

It looks like the sinovac method of inactivating the COVID virus is a generic technique that binds up the viral RNA so it can't replicate in a human cell.
- This method should be just as effective at inactivating all strains of COVID-19 (including Brazilian, South African and Kent varieties)

What they need to do is to start bulk-manufacturing multiple strains of COVID virus, inactivating them, and producing a "polyvalent" vaccine that works against multiple strains.

This sounds easier than genetic engineering the Wuhan virus to look like all these other strains, and then bulk-manufacturing that hybrid...

It will require an extensive clinical trial (in multiple countries) to test the polyvalent vaccine against multiple different strains...
- All of the vaccine manufacturers are now calculating the odds on what will be the dominant COVID variant(s) in 6 months time, so they can start developing polyvalent vaccines/boosters.

[set fair]

What they need to do is to start bulk-manufacturing multiple strains of COVID virus, inactivating them, and producing a "polyvalent" vaccine that works against multiple strains.

Too right. The E484K mutation was predicted (from lab experiments last august)) to bloom once people's anyibody & Tcell levels fell enough for people to get reinfected. So they could have started testing it then and had it in the vaccines a few months ago.

[Jolly2]

Given that the technology is tried and tested and  Chinese inactivated vaccine appears to work, should we have been persuing àn inactivated virus vaccine in march 2020.

I would have gone with an inactivated virus vaccine over an mRNA, simply because it should elicit a wider range of immune response, and potentially help those vaccinated against mutations as a result. Still people that have had covid maybe shouldnt get the vaccine as they now have immunity, should maybe start a thread to discuss the implications of vaccinating someone with aquired immunity as the vaccine will trigger the activation of the reserve antibodies from the original infection,  and potentially interfere.

Would it have been quicker?
Would it have been faster?

Arnt they the same question? The mRNA and Chinese vaccines all started trials at more or less the same time, its apparently cheaper to produce mRNA vaccine but atleast for the current vaccines doent appear to be any quicker.

Would it have been easier to produce?

Cheaper for the mRNA not sure it's easier. Rather simple process to produce a virus and then deactivate it maybe more time consuming as you have to wait for the virus' to develop. Not sure it's as easier to produce an mRNA strand and wrap it in a nanoparticle plus the mRNA is still a novel treatment.

Found this link from politics everything you need know about the Chinese Inactivated virus vaccine. https://www.politico.eu/article/everything-you-need-to-know-china-coronavirus-vaccines/

[Jolly2]

Would producing a deactivated virus to the Brazilian strain be faster or can a Genetic engineered vaccine cover much more all in one.

It looks like the sinovac method of inactivating the COVID virus is a generic technique that binds up the viral RNA so it can't replicate in a human cell.
- This method should be just as effective at inactivating all strains of COVID-19 (including Brazilian, South African and Kent varieties)

What they need to do is to start bulk-manufacturing multiple strains of COVID virus, inactivating them, and producing a "polyvalent" vaccine that works against multiple strains.

This sounds easier than genetic engineering the Wuhan virus to look like all these other strains, and then bulk-manufacturing that hybrid...

It will require an extensive clinical trial (in multiple countries) to test the polyvalent vaccine against multiple different strains...
- All of the vaccine manufacturers are now calculating the odds on what will be the dominant COVID variant(s) in 6 months time, so they can start developing polyvalent vaccines/boosters.

Are you suggesting they will give a polyvariant inactived virus vaccine as a booster to people vaccinated with the mRNA shots?

Wont the antibodies gernerated from the original vaccine be called in to fight it, and therefore interfere with the actual effectiveness?

If I was in a country that hasnt yet started a vaccination program,  I would be looking for a polyvariant inactived virus vaccine for all those not having natural immunity. to be the first vaccine program deployed. But in countries where mRNA vaccines have already been used I'm not sure it would be as effective, simply because the now present antibodies might interfere.

We need effective treatments.

[Bored chemist]

We need effective treatments.

We have several.
And the "first to market" were not inactivated virus ones.

So, if the industry had decided to do what you advocate, the vaccination program would have taken longer to get started, and more people would have died.

Don't you think it's time to stop saying it was a good idea?

And, of course, as that article says.
"But the Chinese jabs are no magic bullet. The efficacy data supporting the vaccines is neither public nor peer-reviewed, and many worry that some of them might not be as effective as their Western counterparts. EU countries that have or will use the vaccines are doing so without the European Medicines Agency’s sign-off — meaning they must assume liability if an issue arises later."

[Petrochemicals (OP)]

Would it have been quicker?
Would it have been faster?

Arnt they the same question? The mRNA and Chinese vaccines all started trials at more or less the same time, its apparently cheaper to produce mRNA vaccine but atleast for the current vaccines doent appear to be any quicker.

Yes they are jolly and thanks for the info. Do they grow this one in chicken eggs too?

It seems Chile may be experiencing the effect of the inactivated virus being the wrong strain, as is seen in flu vaccines. Even though they are heavily vaccinated in Chile it does not seem to have made a dent in either the cases or mortality figures. As Jolly points out, it is harder to make the deactivated virus vaccine so it must be harder to change strain types too.

[Petrochemicals (OP)]

The answer is yes, yes we should.

https://www.who.int/news-room/feature-stories/detail/the-sinovac-covid-19-vaccine-what-you-need-to-know

Hindsight is a wonderful thing.

[paul cotter]

Petro, hindsight is the ONLY exact science.

[Petrochemicals (OP)]

Petro, hindsight is the ONLY exact science.

Well the thread read as whether inactivating a virus into avaccine was quicker. Inactivated virus was functional and tried and tested and as it turns out viable. This really should have been at least one of the vaccines we invested in.

[Petrochemicals (OP)]

And the MRNA vaccine has it, (a Nobel prize that is)

https://www.bbc.com/news/health-66983060

[alancalverd]

More interestingly, I understand that WHO has now approved a malaria vaccine.

[paul cotter]

If that malaria vaccine works it will be of enormous benefit, given the burden of disease caused by malaria. Being a parasite rather than a virus producing a vaccine must have been difficult. I wonder does it work on all four types of malaria or just the really dangerous one, falciparum. On petro's original question I think I can supply an answer: we now have an inactivated virus vaccine, namely novovax, and it is the one I received in the spring having had heart rhythm disturbances on my three previous Pfizer shots(and also from covid which I contracted last summer). But look at the timeline, it was nearly two years after the mrna vaccines. We could not have waited.