Can RNA interference alter the next generation?

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Offline thedoc

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Can RNA interference alter the next generation?
« on: 19/07/2012 16:30:01 »
Matt Copas  asked the Naked Scientists:
Could a RNAi based silencing effect the DNA of the next generation by silencing a gene in a mothers eggs before they were formed? Thanks in advance and I love the show.

Matthew Copas

West Union, Ohio
United States

What do you think?
« Last Edit: 19/07/2012 16:30:01 by _system »


Offline chris

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Re: Can RNA interference alter the next generation?
« Reply #1 on: 20/07/2012 09:24:35 »
That's a tricky one. If the RNAi impacted on a genetic circuit linked to epigenetic programming, whereby chemical tags are added to the sides of genes to control their activity, this could have a heritable effect, because scientists have discovered that epigenetic effects can be heritable.

But on the whole, RNAi produces a temporary arrest of expression of a specific genetic message by triggering the target mRNA sequence to be degraded.

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