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Diagnosis and treatment of vitamin D deficiency. Cannell JJ, Hollis BW, Zasloff M, Heaney RP.Atascadero State Hospital, 10333 El Camino Real, Atascadero, California 93422, USA. jcannell@ash.dmh.ca.govThe recent discovery--in a randomised, controlled trial--that daily ingestion of 1100 IU of colecalciferol (vitamin D) over a 4-year period dramatically reduced the incidence of non-skin cancers makes it difficult to overstate the potential medical, social and economic implications of treating vitamin D deficiency. Not only are such deficiencies common, probably the rule, vitamin D deficiency stands implicated in a host of diseases other than cancer. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets > 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. A common misconception is that government agencies designed present intake recommendations to prevent or treat vitamin D deficiency. They did not. Instead, they are guidelines to prevent particular metabolic bone diseases. Official recommendations were never designed and are not effective in preventing or treating vitamin D deficiency and in no way limit the freedom of the physician--or responsibility--to do so. At this time, assessing serum 25-hydroxy-vitamin D is the only way to make the diagnosis and to assure that treatment is adequate and safe. The authors believe that treatment should be sufficient to maintain levels found in humans living naturally in a sun-rich environment, that is, > 40 ng/ml, year around. Three treatment modalities exist: sunlight, artificial ultraviolet B radiation or supplementation. All treatment modalities have their potential risks and benefits. Benefits of all treatment modalities outweigh potential risks and greatly outweigh the risk of no treatment. As a prolonged 'vitamin D winter', centred on the winter solstice, occurs at many temperate latitudes, < or = 5000 IU (125 microg) of vitamin D/day may be required in obese, aged and/or dark-skinned patients to maintain adequate levels during the winter, a dose that makes many physicians uncomfortable.Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
"Keep away from the sun to avoid cancer""multivitamin pills shorten your life"
...To the authors' knowledge, plaintiffs' attorneys are not yet involved in the vitamin D debate. After the findings of Lappe et al. (1), it may only be a matter of time until lawsuits against physicians begin to appear, claiming that physicians dispensed sun-avoidance advice, but negligently failed to diagnose and treat the consequent vitamin D deficiency, leading to fatal cancers. Unless the future literature fails to support the present, such medical malpractice suits may become commonplace.Finally, physicians and policy-makers should understand that much of the future of vitamin D is out of their hands. Inexpensive high-dose supplements are now widely available to the American public over-the-counter and to the world via the Internet. Sunlight remains free. A Google search for 'vitamin D' reveals several million hits. After the Canadian Cancer Society recently recommended 1000 IU/day for all Canadian adults in the wintertime, vitamin D disappeared off the shelves, causing a shortage during the summer.The pleiotropic actions and unique pharmacology of vitamin D mean educated patients, on their own, can entirely control their own tissue levels of this steroid, through either UVB exposure or over-the-counter supplementation. Given the attitudes that some in mainstream medicine have about any substance with the word 'vitamin' in it (105), the public and not the medical profession may be the first to enter the vitamin D era.
...The pleiotropic actions and unique pharmacology of vitamin D mean educated patients, on their own, can entirely control their own tissue levels of this steroid, through either UVB exposure or over-the-counter supplementation. Given the attitudes that some in mainstream medicine have about any substance with the word 'vitamin' in it (105), the public and not the medical profession may be the first to enter the vitamin D era.http://www.vitamindcouncil.org/PDFs/diagnosis-vitdd.pdf
Quote from: neilep on 21/05/2008 16:01:37Quote from: iko on 21/05/2008 10:01:40Easy question Neilepus amicissimus,the answer MIGHT be right here:http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=529704EnjoyikodAWESOME !!!..Vitamin D Rules !!...If only I knew a good source of Vitamin D !! [] []Hi Neilepus rapidofastissimus thread-makerus!Cod liver oil is no good for 'boosting' your vitamin D: plenty of vitamin A and omega-3 fatty acids plus 'some' vitamin D.It probably works in the long run as far as vitamin D3 is concerned (approx. 400 I.U./day).So dear old 'cod' is still used daily in northern Europe, during months with the 'R': from September to April.Short 'flashes' (30min.) of sushine between 10a.m. to 2p.m. at a proper latitude (no clouds please) really boost your skin production of vitamin D3 (>20,000 I.U.)Sorry you cannot read the complete paper previously cited by ikus.You would be impressed by a 1918 study about flu reported in the article.Shortly, in 1918, trying to find out how influenza viruses managed to infect people and to verify relative incubation times (2-3 days), proper experiments were set up using human volunteers. Forget the details [xx(]...but secretions from infected patients were carefully collected, mixed up and flushed through the nostrils of brave volunteers. []Surprisingly enough, nothing happened afterwards, so the experiment was considered a 'fiasco'.Only now, 90 years later, a crystal-clear explanation is ready for this.Anti-infective properties of vitamin D were proved only 4-5 years ago, when the cathelicidin pathway was described.Those volunteers were healthy men from the Navy.Probably well-tanned all year round, perfectly healthy, they had been selected for not having had a flu in the previous months, to avoid an 'immunization' bias.Maybe a good level of vitamin D helped them to block the influenza viruses quickly.For the same reason, somewhere in 2005, most (maybe all) vitamin D supplemented patients in Dr J.Cannell department, Atascadero CA, went through a big influenza epidemic perfectly healthy.John Cannell was the 'prepared mind', times were changing, so the vitamindcouncil.com crusade started.One hypothesis out of many is that flu viruses do circulate all year round in humans, but give troubles in some people only in the cold season, i.e. when vitamin D levels are low.So much for the anti-flu vaccination campaigns.http://www.youtube.com/watch?v=enB6BuOjXY8P.S.The reason why Chris is not commenting on these issues is simple: he is a virology expert and knows much better than others the other side of the coin.Everybody is waiting for final scientific proofs about vitamin D and flu, but most of all about vitamin D benefits in other dreadful diseases.Wonderful hypotheses need extended and accurate studies to become Science. It takes so much time.I'm sure Chris will never have to decide from trembling hypotheses whether to give 'cod' to one of his kids or NOT.It happened to me, after years of serious searches and rigorous evidence-based training.That's life.Hypothesis--ultraviolet-B irradiance and vitamin D reduce the risk of viral infections and thus their sequelae, including autoimmune diseases and some cancers.Grant WB.Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA. wgrant@infionline.netMany viral infections reach clinical significance in winter, when it is cold, relative humidity is lowest and vitamin D production from solar ultraviolet-B irradiation is at its nadir. Several autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus and asthma, are linked to viral infections. Vitamin D, through induction of cathelicidin, which effectively combats both bacterial and viral infections, may reduce the risk of several autoimmune diseases and cancers by reducing the development of viral infections. Some types of cancer are also linked to viral infections. The cancers with seemingly important risk from viral infections important in winter, based on correlations with increasing latitude in the United States, an index of wintertime solar ultraviolet-B dose and vitamin D, are bladder, prostate, testicular and thyroid cancer, Hodgkin's and non-Hodgkin's lymphoma, and, perhaps, gastric cancer. The evidence examined includes the role of viruses in the etiology of these diseases, the geographic and seasonal variation of these diseases, and the time of life when vitamin D is effective in reducing the risk of disease. In general, the evidence supports the hypothesis. However, further work is required to evaluate this hypothesis.Photochem Photobiol. 2008 Mar-Apr;84(2):356-65. Epub 2008 Jan 7.
Quote from: iko on 21/05/2008 10:01:40Easy question Neilepus amicissimus,the answer MIGHT be right here:http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=529704EnjoyikodAWESOME !!!..Vitamin D Rules !!...If only I knew a good source of Vitamin D !! [] []
Easy question Neilepus amicissimus,the answer MIGHT be right here:http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=529704Enjoyikod
It's never too late (sometimes)...If you followed this thread so far,you deserve to watch this free video:"The Vitamin D Pandemic and its Health Consequences"Presented by Michael Holick, PhD, MD, Professor of medicine, physiology and biophysicsand director of the General Clinical Research Center at Boston University Medical CenterKeynote address at the opening ceremony of the 34th European Symposium on Calcified Tissues, Copenhagen 5 May, 2007http://www.uvadvantage.org/portals/0/pres/
aaaah, I can see your point now - I didn't know those kinds of ads! I'm afraid I've never heard of Michael Holick's conference. where was that shown?
Could by any chance the old remedy, a relic from the past,an inexpensive nutrient containing vitamins A and D,help leukemic patients in the long run, AFTER treatment?According to this recent study, the answer is yes.Differentiation-inducing liposoluble vitamin deficiency may explainfrequent secondary solid tumors after hematopoietic stem cell transplantationMinireview.Gedikoglu G, Altinoz MA.Secondary cancers are among the most threatening long-term health problems of hematopoetic stem cell- transplant (HSCT) patients. There are several lines of evidence indicating the possibility of a prolonged Vitamin A deficiency for solid tumor-type secondary cancers: I- Solid tumors such as oral cavity, head/neck region squamous carcinomas, skin cancers and melanomas, where lowered Vitamin A concentrations and chemo-preventing activity of its derivatives (retinoids) are most explicitly proven, arise much more frequently than others. II- Early monitorings: A significant retinol deficiency in HSCT patients is detectable along with a severity of mucositis and the vulnerability to infection. III- Monitoring of other liposoluble vitamins: Vitamin D, a differentiation-inducing vitamin like Vitamin A, showed a sustained decrease. Another similarity of these two vitamins is that they also depend on intestinal absorption and are decreased due to bowel injury by conditioning agents and chronic graft-versus-host disease. IV- Peroxidative reactions and inflammation can directly exhaust retinol levels despite sufficient intake. Considering the similar inhibitory role of Vitamin D analogs (deltanoids) on squamous carcinomas, skin tumors and melanomas, we propose that animal studies and extended vitamin surveillance studies in HSCT patients may unfold a preventive strategy against long-term complications.Neoplasma. 2008;55(1):1-9.
Quote from: iko on 21/07/2007 12:54:35Quote from: iko on 19/10/2006 09:05:56Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg "Il sole dona la vita, il sole se la riprende" Mario Umberto Dianzani, 1975.
Quote from: iko on 19/10/2006 09:05:56Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg "Il sole dona la vita, il sole se la riprende" Mario Umberto Dianzani, 1975.
Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg
Each tablespoon has 40 calories, all 40 of them being from fat."As a dietary supplement, take 1-3 teaspoonfuls daily."So, that's up to 120 extra calories from fat every day.~~~~~~~~~~~~~~~~~~~~~guildaDrug Intervention Tennessee
Good NEWS on D-vitamin!!!Quote M. A. Helou, G. Massey, G. Francis, K. Godder, J. Laver Abstract: Background: Survivors of childhood cancer are at increased risk for osteoporosis. Contributing factors include direct effects of chemotherapy and radiation therapy on bone, secondary hormone deficiencies, and chronic illness. However, vitamin D insufficiency could be a major risk factor during and after cancer therapy. Vitamin D insufficiency is common in healthy school aged children (median 25-hydroxy vitamin D [25(OH)D] = 28 ng/mL, 55% <30 ng/mL, 5% < 10 ng/mL.) Based on this data, we hypothesize that vitamin D insufficiency would be common among children with cancer. If vitamin D insufficiency is prevalent, correction may contribute to better bone health and immune responses in children with cancer. Methods: We determined the serum levels of 25(OH)D, PTH, calcium, and phosphorus for 40 children with leukemia or lymphoma currently on therapy (group 1), 34 children with leukemia or lymphoma off therapy (group 2), 16 children with solid tumors currently on therapy (group 3), and 10 children with solid tumors off therapy (group 4.) Prevalence of 25(OH)D insufficiency ( <32 ng/mL) and severe deficiency (<10 ng/mL) was compared by Chi square test to the healthy reference population (established by Weng, et al.)Results: For the majority of patients, calcium and phosphorus levels were within normal limits. Conclusions: Vitamin D insufficiency was very common in all groups, especially in children with solid tumors on therapy (Group 3.) 25(OH)D levels did improve off therapy, but for Group 2, still remained significantly less than normal reference population (p=0.0001.)The data suggests that vitamin D status should be determined for all children at diagnosis of malignancy with a strong recommendation to consider vitamin D supplementation during treatment and follow up. J Clin Oncol 26: 2008 (May 20 suppl; abstr 10023) http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=35975Something is finally "moving" on the clinical research side...I hope(dream) that many parents -on the other side- are giving 'cod for more than one year'!QuoteUnfortunately, if vitamin D is needed mainly, and too much vitamin A is either toxic or counteracting "D" wonderful effects (J.Cannell et al. Nov.2008), we would need a special cod liver oil formula:a moderate amount of vitamin A, plenty of D-vitamin and lots of omega-3! This probably WAS the original cod liver oil, before they started removing D-vitamin, erroneously thinking that it was too close to toxic amounts.Two thousands I.U. per day of vitamin D3 was considered almost toxic for humans.What a shame: we seem to have destroyed the original formula.
M. A. Helou, G. Massey, G. Francis, K. Godder, J. Laver Abstract: Background: Survivors of childhood cancer are at increased risk for osteoporosis. Contributing factors include direct effects of chemotherapy and radiation therapy on bone, secondary hormone deficiencies, and chronic illness. However, vitamin D insufficiency could be a major risk factor during and after cancer therapy. Vitamin D insufficiency is common in healthy school aged children (median 25-hydroxy vitamin D [25(OH)D] = 28 ng/mL, 55% <30 ng/mL, 5% < 10 ng/mL.) Based on this data, we hypothesize that vitamin D insufficiency would be common among children with cancer. If vitamin D insufficiency is prevalent, correction may contribute to better bone health and immune responses in children with cancer. Methods: We determined the serum levels of 25(OH)D, PTH, calcium, and phosphorus for 40 children with leukemia or lymphoma currently on therapy (group 1), 34 children with leukemia or lymphoma off therapy (group 2), 16 children with solid tumors currently on therapy (group 3), and 10 children with solid tumors off therapy (group 4.) Prevalence of 25(OH)D insufficiency ( <32 ng/mL) and severe deficiency (<10 ng/mL) was compared by Chi square test to the healthy reference population (established by Weng, et al.)Results: For the majority of patients, calcium and phosphorus levels were within normal limits. Conclusions: Vitamin D insufficiency was very common in all groups, especially in children with solid tumors on therapy (Group 3.) 25(OH)D levels did improve off therapy, but for Group 2, still remained significantly less than normal reference population (p=0.0001.)The data suggests that vitamin D status should be determined for all children at diagnosis of malignancy with a strong recommendation to consider vitamin D supplementation during treatment and follow up. J Clin Oncol 26: 2008 (May 20 suppl; abstr 10023)
Unfortunately, if vitamin D is needed mainly, and too much vitamin A is either toxic or counteracting "D" wonderful effects (J.Cannell et al. Nov.2008), we would need a special cod liver oil formula:a moderate amount of vitamin A, plenty of D-vitamin and lots of omega-3! This probably WAS the original cod liver oil, before they started removing D-vitamin, erroneously thinking that it was too close to toxic amounts.Two thousands I.U. per day of vitamin D3 was considered almost toxic for humans.What a shame: we seem to have destroyed the original formula.
From January 2008 VitaminD Newsletter:Quote...All of the epidemiological and animal studies in the literature suggest cancer patients will prolong their lives if they take vitamin D. I can't find any studies that indicate otherwise. However, none of the suggestive studies are randomized controlled interventional trials; they are all epidemiological or animal studies, or, in the case of Vieth's, an open human study. However, if you have cancer, or your child does, do you want to wait the decades it will take for the American Cancer Society to fund randomized controlled trials using the proper dose of vitamin D? Chances are you, or your child, will not be around to see the results. John Cannell, MDhttp://content.ll-0.com/vitalchoiceseafood/Cannell.John.140.jpghttp://www.vitamindcouncil.com/http://www.lung.ca/tb/images/full_archive/006_codLiverOil.jpghttp://karmadaze.com/sunrise.jpg
...All of the epidemiological and animal studies in the literature suggest cancer patients will prolong their lives if they take vitamin D. I can't find any studies that indicate otherwise. However, none of the suggestive studies are randomized controlled interventional trials; they are all epidemiological or animal studies, or, in the case of Vieth's, an open human study. However, if you have cancer, or your child does, do you want to wait the decades it will take for the American Cancer Society to fund randomized controlled trials using the proper dose of vitamin D? Chances are you, or your child, will not be around to see the results. John Cannell, MDhttp://content.ll-0.com/vitalchoiceseafood/Cannell.John.140.jpghttp://www.vitamindcouncil.com/
News, news, news!25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services.Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, Bergethon P, Rosenberg IH, Folstein MF, Patz S, Bhadelia RA, Tucker KL.From the Friedman School of Nutrition Science and Policy (J.S.B., T.M.S., G.E.D., I.H.R., K.L.T.), Tufts University; Tufts Medical Center (T.M.S., D.E.W., W.Q.Q., M.F.F., S.P., R.A.B.), Tufts University School of Medicine; Jean Mayer USDA Human Nutrition Research Center on Aging (B.D.-H., G.E.D., I.H.R., K.L.T.); Beth Israel Deaconess Medical Center (R.A.B.); and Boston University Medical Center (P.B.), Boston, MA.BACKGROUND: Vitamin D deficiency has potential adverse effects on neurocognitive health and subcortical function. However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD). METHODS: Cross-sectional investigation of 25-hydroxyvitamin D [25(OH)D], dementia, and MRI measures of CVD in elders receiving home care (aged 65-99 years) from 2003 to 2007. RESULTS: Among 318 participants, the mean age was 73.5 +/- 8.1 years, 231 (72.6%) were women, and 109 (34.3%) were black. 25(OH)D concentrations were deficient (<10 ng/mL) in 14.5% and insufficient (10-20 ng/mL) in 44.3% of participants. There were 76 participants (23.9%) with dementia, 41 of which were classified as probable AD. Mean 25(OH)D concentrations were lower in subjects with dementia (16.8 vs 20.0 ng/mL, p < 0.01). There was a higher prevalence of dementia among participants with 25(OH)D insufficiency (</=20 ng/mL) (30.5% vs 14.5%, p < 0.01). 25(OH)D deficiency was associated with increased white matter hyperintensity volume (4.9 vs 2.9 mL, p < 0.01), grade (3.0 vs 2.2, p = 0.04), and prevalence of large vessel infarcts (10.1% vs 6.9%, p < 0.01). After adjustment for age, race, sex, body mass index, and education, 25(OH)D insufficiency (</=20 ng/mL) was associated with more than twice the odds of all-cause dementia (odds ratio [OR] = 2.3, 95% confidence interval [CI] 1.2-4.2), Alzheimer disease (OR = 2.5, 95% CI 1.1-6.1), and stroke (with and without dementia symptoms) (OR = 2.0, 95% CI 1.0-4.0). CONCLUSIONS: Vitamin D insufficiency and deficiency was associated with all-cause dementia, Alzheimer disease, stroke (with and without dementia symptoms), and MRI indicators of cerebrovascular disease.These findings suggest a potential vasculoprotective role of vitamin D.Neurology. 2009 Nov 25. [Epub ahead of print]
A promise is a promise... []so here you find D-vitamin safety limits: Risk assessment for vitamin D. Hathcock JN, Shao A, Vieth R, Heaney R.Council for Responsible Nutrition, Washington, DC 20036-5114, USA. jhathcock@crnusa.orgThe objective of this review was to apply the risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D. New data continue to emerge regarding the health benefits of vitamin D beyond its role in bone. The intakes associated with those benefits suggest a need for levels of supplementation, food fortification, or both that are higher than current levels. A prevailing concern exists, however, regarding the potential for toxicity related to excessive vitamin D intakes. The UL established by the FNB for vitamin D (50 microg, or 2000 IU) is not based on current evidence and is viewed by many as being too restrictive, thus curtailing research, commercial development, and optimization of nutritional policy. Human clinical trial data published subsequent to the establishment of the FNB vitamin D UL published in 1997 support a significantly higher UL. We present a risk assessment based on relevant, well-designed human clinical trials of vitamin D.Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL.Am J Clin Nutr. 2007 Jan;85(1):6-18.Free full text to enjoy real Science! http://www.ajcn.org/cgi/reprint/85/1/6
D-vitamin newsletter! [] [] [] Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. Sabetta JR, Depetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML.Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.AbstractBACKGROUND: Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections. This study was done to determine if serum 25-hydroxyvitamin D concentrations correlated with the incidence of acute viral respiratory tract infections. METHODOLOGY/FINDINGS: In this prospective cohort study serial monthly concentrations of 25-hydroxyvitamin D were measured over the fall and winter 2009-2010 in 198 healthy adults, blinded to the nature of the substance being measured. The participants were evaluated for the development of any acute respiratory tract infections by investigators blinded to the 25-hydroxyvitamin D concentrations. The incidence of infection in participants with different concentrations of vitamin D was determined. One hundred ninety-five (98.5%) of the enrolled participants completed the study. Light skin pigmentation, lean body mass, and supplementation with vitamin D were found to correlate with higher concentrations of 25-hydroxyvitamin D. Concentrations of 38 ng/ml or more were associated with a significant (p<0.0001) two-fold reduction in the risk of developing acute respiratory tract infections and with a marked reduction in the percentages of days ill.CONCLUSIONS/SIGNIFICANCE: Maintenance of a 25-hydroxyvitamin D serum concentration of 38 ng/ml or higher should significantly reduce the incidence of acute viral respiratory tract infections and the burden of illness caused thereby, at least during the fall and winter in temperate zones. The findings of the present study provide direction for and call for future interventional studies examining the efficacy of vitamin D supplementation in reducing the incidence and severity of specific viral infections, including influenza, in the general population and in subpopulations with lower 25-hydroxyvitamin D concentrations, such as pregnant women, dark skinned individuals, and the obese.PLoS One. 2010 Jun 14;5(6):e11088http://www.paesionline.it/foto_italia/DD1004_sci_estivo_tonale.jpg
"...From a clinical perspective, vitamin D insufficiency represents the first potentially modifiable prognostic marker in chronic lymphocytic leukemia (CLL) by presenting the opportunity for patients to have their serum vitamin D checked and, if they are deficient, vitamin D supplements administered to correct the deficit."...CLL: a supplementary question?Pepper C, Fegan C.Cardiff University.Comment on:Blood. 2011 Feb 3;117(5):1492-8. AbstractIn this issue of Blood, Shanafelt and colleagues provide the first evidence that vitamin D deficiency is a risk factor for disease progression in chronic lymphocytic leukemia (CLL). Their findings imply that dietary vitamin D supplementation could potentially modify the natural history of this incurable disease.Blood. 2011 Feb 3;117(5):1439-40.http://bloodjournal.hematologylibrary.org/cgi/reprint/117/5/1439
Ok, we seem to be almost THERE.It's a pity we didn't start from childhood leukemias...they are not incurable, in fact, but curable in the majority of patients (well over 50%), not enough though. "To see what is in front of one's nose needs a constant struggle." George OrwellIf, in the near future, proper vitamin D3 supplementation improves survival in childhood leukemias... Well...I'm going to take a week off, a month off...maybe a whole year off!Ikod