[nTonic]

Thanks so much for the info demografx. It is very surprising for me because I have never thought of the proposition that POIS has to do with hormone. I always thought it had to do with my spine (since I always have a sore lowerback on day 1) and/or inflammation (due to my sore eyes).

Has anyone here tried anti-inflammtory drugs and do they have any effect? And can I also ask how one should approach the GP so that they could actually let him/her try medication that might help?

[demografx]

Thanks so much for the info demografx. It is very surprising for me because I have never thought of the proposition that POIS has to do with hormone. I always thought it had to do with my spine (since I always have a sore lowerback on day 1) and/or inflammation (due to my sore eyes).

Good questions! Lower back problems have been discussed. Take a look at some of our previous forum discussions about the lower back:
http://www.google.com/search?hl=en&q=lower+back+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com

When you see a result that you like, click on it, then use Ctrl + F plus a keyword(s) to zero in on your specific post.

Has anyone here tried anti-inflammtory drugs and do they have any effect?

We have had a number of discussions there, too:
http://www.google.com/search?hl=en&q=anti+inflammatory+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com

And can I also ask how one should approach the GP so that they could actually let him/her try medication that might help?

Our experience is that, unfortunately, we need to be a little aggressive with doctors or we will get little or no help! That's one reason the resources are spelled out in your welcome post above. I would suggest printing out Dr. Waldinger's paper, the New York Times article and bring it to your GP. Then talk about this forum and its seriousness on a scientific website.

The reason for all this is that, as B_Jim points out, we are in the infancy stages of the science of orgasm. It is a rare malady, misunderstood by 99.99% of the medical community.

We are here to help each other get beyond that and into an effective treatment mode as rapidly as possible.

[demografx]

Welcome nTonic. I suggest to test C-reactive protein (CRP)in Pois. It seems to be  very easy and reliable for inflammation (Il-6). Out-of Pois I had about 4mg/L. ( <5mg/L = no inflammation  ).
  

B_Jim, do you think he should also test for the other hormones, prolactin, testosterone, cortisol, etc. ?

[demografx]

I don't recall the number of sufferers who may have itching or skin irritation. This would be VERY interesting if some of you have this?

Underwater, I have always had "burning" fingertips in POIS, a most miserable sensation. I went to a dermatologist who confirmed that I also had dermatitis on my fingertips in-POIS. No creams, moisture, etc., Rx or OTC, would ever help.

[demografx]

POIS DIARY

Trial #5, Day Zero. Very mild symptoms, expect none tomorrow. The reason first 2 Trials were 75% POIS cure, the next 2 Trials 90%+ POIS cure: repeat activity on the first 2 trials, averaging 4X in 4 days, which in the past would have created POIS-devastation on the scale of a personal nuclear holocaust.

The POIS treatment of testosterone + Levitra creates much more desire, so now activity needs to be constrained somewhat to keep the 90%+ level. It's an adjustment and a challenge.

But it's a great new life after 30+ years of POIS agony. Thanks, forum.

[underwater]

Had a significant NE last night since I hadn't had an "O" in 3 months---
Immediately took an antihistamine (Claritin)---
I observed that my initial usual  POIS symptoms of sweating, tingles, hot/cold sensations did not take place. All H1 receptor sites on skin were taken out of the POIS symptomatology for ME. I also noticed no stuffed sinus or dry mouth. All this makes sense for combating allergies, but it clearly works for my initial POIS symptoms too. I made the mistake about 15 hours later of taking another Claritin.
This was a mistake. Side effects have scrambled things and have made clear analysis impossible. Right at the moment, I can't separate POIS from Claritin side effects.
Now it's about 19 hours post NE. I have learned a lot about what causes my initial symptoms. I'm not sure I can clearly observe further due to excess Claritin. I took the extra Claritin because I was not sure how long the histamine released from mast cells at orgasm remains in the blood. I should have waited and observed instead of trying to overdo it. At least I may have some valuable information for the onset of my type of POIS and how to prevent some early symptoms. This has been risky for me because I don't want to stir things up with my anxiety condition. I've also experimented with Claritin to see how it affects GAD. I also suspect other mast cell mediators besides histamine playing a part in POIS. The one symptom that was not shut down was perineum burning. I will watch to see how long until it subsides. I will keep an eye on fatigue and cognitive issues. But I think all my good information may be just for the first 15 hours. I do not think Claritin is the answer, but at least it may offer some insight into the possibility of an inflammatory response theory. I never got the initial jolt or panic that I always get. I hope I don't get it later on. If I do, this experiment will be a failure by simply delaying the inevitable.

[demografx]

Underwater, it does sound meaningful, the 15 hours, in spite of the "setbacks".

I'm keeping my fingers crossed that the initial sudden jolt will not re-emerge.

Please keep us informed.

Best wishes.

[underwater]

Just got out of bed. This is second night, but first full night's sleep. This is report on hours 20-29 post "O". Slept like a baby. This would usually be a bad night.
Zero POIS symptoms! I can easily distinguish Claritin symptoms from POIS: There is no POIS. The Claritin symptoms are slight increase in heart rate and a mild anxiety. There was no impact on my sleep. I don't know if second Claritin was necessary. The issue is: How long do mast cell mediators operate after arousal and orgasm? How long do they have to be inhibited from binding to their sites? This experiment is about Histamine. Claritin prevents binding to H1 receptors. This means avoiding symptoms that are connected to places like skin and sinuses for example. Since I slept well, at the moment I feel well rested. I won't know about my back and perineum for awhile.
I pray and hope that the inflammatory response  has been interfered with. Cognitively, I feel my usual self as I type this. Maybe for me, I just can't handle all the histamines released to trigger ejaculation? I asked the pharmacist yesterday about other mediators like prostaglandin and leukotreine (I'm not sure about spelling), but she didn't know. She said the blockers for them are usually by prescription. But this experiment is not about medication/Claritin. It is about learning what might be POIS triggers just before or at orgasm. I think it is true that POIS is a question of hormones and neurotransmitters. Histamine, as far as I know, is classified as a neurotransmitter. In my case, with my GAD and allergies, it is hard to separate symptoms out. But I know that allergens cause allergies. Histamine is a culprit. I think that my early POIS symptoms and quite possibly some of my GAD symptoms are Histamine reactions. In fact, maybe all of my "somatic" POIS symptoms are Histamine related???

[demografx]

Just got out of bed. This is second night, but first full night's sleep. This is report on hours 20-29 post "O". Slept like a baby. This would usually be a bad night.

Zero POIS symptoms!

Underwater, congratulations! Major step.

[demografx]

POIS DIARY

DAY ONE, to use Underwater's expressions above: slept like a baby. Zero POIS symptoms.

Too much Levitra = hangover + too much post-arousal. I cut back from 20mg to 10mg. Will go to 5mg next time.

[underwater]

Demo----
Thanks for the support
Jim_B----
I hope my experiment adds a little bit to the discussion

This whole thing seems surrealistic. I have learned quite a bit the last several months, because this forum stimulates the thought process. I would not be thinking if I were not writing. I remember reading about Waldinger a few years back and his autoimmune thesis, but it didn't mean much to me. I always figured there may be a negative response to semen or something else. I had no idea we released histamines at orgasm. This forum forces one to do research. That is good. The unfortunate thing is that we have to experiment on ourselves--ouch! I can't even believe that I once thought POIS was psychological, although I believe there is a psychological component to the symptomatology. For me, I have to wade through POIS, GAD and Allergies. It would be a miracle of miracles if Histamine -along with possibly other unknown culprits- was the source of all my conditions? I'd certainly like to find at least some relief at sixty. So far at 33 hours, no trace of POIS. Claritin seems to have worn off. I will not take another. I will post later this evening around 43 hours.

[demografx]

It would be a miracle of miracles if Histamine -along with possibly other unknown culprits- was the source of all my conditions? I'd certainly like to find at least some relief at sixty.

Very often I think a simple solution is the answer (Occam's Razor). The "miracle of miracles" for me is testosterone + Levitra, hardly a complex regimen! But like you, I'm surprised. And all it took for me was a simple bloodtest and an obvious observation of my ED []

I will post later this evening around 43 hours.

Looking forward to it!

[Counterpoints]

For inflammation, hs-CRP (high sensitivity CRP) and ESR (erythrocyte sedimentation rate) tests might be best (preferably both tested at the same time).

[underwater]

It's about 42 hours since "O"--
The day was fine, and I had no POIS symptoms--
The moderate back pain and associated perineum burning dissipated around 30 hrs. This is optimistic because these two problems always stayed with me the longest; at least 5 days. In fact, these two symptoms have always signaled that I'm well into POIS.
It feels like the Claritin is out of my system. And the little research that I've done on free Histamine suggests that it is gone also. It is also possible that my supplements have contributed to the results of this experiment. (If anybody is interested, I'll list them). I also have been drinking significantly more fluids the last 2-3 weeks, along with a lot of frozen cherries and other berries. I also stopped swimming a month ago, replaced with long distance walking. I need to digest what has just happened and continue to focus on improving my anxiety condition. I intend to experiment with SAMe and/or methionine in a day or two to try and help blunt my Histamine production. 

[demografx]

Congratulations, Underwater!

[nTonic]

It's so encouraging to see Underwater having progress with Claritin. I might give it a go as well!

I have seen that one of the members here tried DHEA and it worked for him. I wonder if there's anyone else trying it and whether it has any effect?

[demografx]

I have seen that one of the members here tried DHEA and it worked for him. I wonder if there's anyone else trying it and whether it has any effect?

nTonic, here are some forum posts about DHEA:
http://www.google.com/search?hl=en&q=+DHEA+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com

After you click on a result you're interested in, use Ctrl + F and type keyword(s) to zero in on the specific post you're looking for.

[demografx]

It's so encouraging to see Underwater having progress with Claritin. I might give it a go as well!

POISitin® kidding aside, I do see now that my nose is stuffed up immediately afterwards. I use Afrin to clear it up. Maybe Claritin will up my cure?

[demografx]

Dr. Marcel Waldinger, neuropsychiatrist, Primary Investigator and author of classic 2002 POIS Study. He is in communication with our POIS Forum here at The Naked Scientists. For a copy of his POIS study, send a private message to pyropeach with your email address and he will send you a copy.

Marcel D. Waldinger, MD, PhD is neuropsychiatrist and head of the Department of Consultative Psychiatry and the outpatient Department of Neurosexology at Leyenburg Hospital in The Hague in The Netherlands.

He is Associate Professor in Sexual Psychopharmacology at the Faculty of Pharmaceutical Sciences of the University of Utrecht in The Netherlands.

Since 1992 Dr. Waldinger treats and investigates premature ejaculation (ejaculatio praecox) and other ejaculatory problems. In 1997 he received his PhD on this subject.

His renewing ideas and studies have been published in various scientific journals and daily newspapers.

The outpatient Department of Neurosexology of the Leyenburg Hospital in The Hague has been the most specialized outpatient clinic for the treatment of premature ejaculation in the Netherlands and Europe for the last 15 years.

[demografx]

Dr. Dave Schweitzer, co-author of original 2002 POIS Study with Dr. Marcel Waldinger, also in touch with our forum here, since 1994 internist-endocrinologist in Reinier de Graaf Groep, Netherlands. His interest is mainly in hormonal diseases and diseases of the metabolism. He does research on the endocrinology of sexuality and seriously overweight. His work is published in international journals.