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Each O digs me further underground.
Quote from: demografx on 19/08/2009 00:58:18I asked my endo how to improve my 75% POIS cure. He said to test Estradiol and other hormones.Quote from: demografx on 26/09/2009 04:43:47As another POIS experiment today (sparked by the usual in-POIS carbs-craving) I drank a "ton" of orange juice throughout the day. That, plus doubling the Rx stimulant-dose(again, with psychiatric approval) as mentioned in the first post at the top of this page, shortened the time of POIS symptoms significantly.I know this goes counter to some people who studiously avoid carbs. But we're all built differently and, I think, have different forms of POIS.for the good effect with orange it can be naringenin in it (or vitamin c!).This substance is a natural aromatase inhibitor which prevent the conversion of testosterone into estradiol(which is anti testosterone).from wiki:Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. It is the predominant flavanone in grapefruit.[1]Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2 Sources and bioavailability:Grapefruit, Oranges, and Tomato (skin).Also I heard that grapefruit juice is prohibited to avoid overdosing with some prescriptions drugs including some antidepressants. (this is very serious!). Not sure if naringenin is involved :http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1873672Maybe aromatase inhibitors can help us with POIS:-chrysin (passiflora) -naringenin(grapefruit)-resveratrol(grape)http://en.wikipedia.org/wiki/ResveratrolResveratrol also significantly increases natural testosterone production from being both a selective estrogen receptor modulator[73][74] and an aromatase inhibitor.[75][76]
I asked my endo how to improve my 75% POIS cure. He said to test Estradiol and other hormones.
As another POIS experiment today (sparked by the usual in-POIS carbs-craving) I drank a "ton" of orange juice throughout the day. That, plus doubling the Rx stimulant-dose(again, with psychiatric approval) as mentioned in the first post at the top of this page, shortened the time of POIS symptoms significantly.I know this goes counter to some people who studiously avoid carbs. But we're all built differently and, I think, have different forms of POIS.
Martin, you've researched testosterone extensively and have a lot of knowledge in this area: do you think it's possible for someone to take testosterone and not have their body shut down its own natural production of testosterone?
Thanks, Martin. I simply thought my heavy dose of orange was only a "sugar rush", but the aromatose inhibition seems very logical!
Martin, you've researched testosterone extensively and have a lot of knowledge in this area: do you think it's possible for someone to take testosterone and not have their body shut down its own natural production of testosterone? If so, I would like to approach a testosterone manufacturer to see if they can do a clinical trial on us for POIS. For motivation, there is potentially a new worldwide market for them!
just to report my trials with 100% pure cranberry juice. I couldn't find whole fruits. Unfortunately I had no success for POIS. More than 3 glasses in a row slightly increased my anxiety. But it's probably good to drink in long term for antioxydants. One funny thing, cranberry juice mixed with orange juice taste a bit like grapefruit.the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...
Quote from: martin88 on 28/09/2009 14:26:39the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...With cortisol like that it is going to be hard to get a doctor to check your high ACTH.
the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...
Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.
demo,it sounds interesting, but there are not very many people with pois, their future sales from us(mostly forum members of this site) probably would not pay for their study.
anabolic steroids severely increase chances of getting cancer.
I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.
I think we should take advantage of the 500,000 hits for the purpose of convincing big pharma that there are tons of people out there with pois and that they can make a lot of money.
Quote from: demografx on 28/09/2009 19:53:09Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.Quote from: martin88 on 28/09/2009 14:26:39I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.Thanks, Martin!OK, if I understand the response to my post correctly, there are only two (2) people here who are possibly interested in a clinical trial/research study of POIS and testosterone. Which is not enough for me to approach Watson Pharmaceuticals, Inc. If I'm wrong, and you are interested, please let me know by posting your interest here or by PM! Thank you.
Hello guys,I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.I truly believe that this is the way to go to combat this awful POIS!Paul