[daveman]

.....and on feeling of physical fatigue.
Thanks in advance.

The other day when I had my crisis, my blood pressure went quite high. To the point that I could probably attribute many/most of my symptoms to the high blood pressure. I must add, that high blood pressure for me may be different than for many, because I have a cronic condition, and although controlled normally, years of wear and tear make me much more susceptable. Also this pressure rise was not because of the excersize/rush of sex, because those effects for me are usually short lived. It was a POIS initiated rise and lasted for about 20 hrs.

Anyways, physical fatigue is a one of the symptoms of high blood pressure. On other occasions, I have eaten late at night with maybe a wine or two (maybe three) and the next day, when I go to work there's an overpass that I have to climb. If I eat late, my system rebels and my pressure goes up a fair bit. And that next morning, the overpass presents quite a problem!

I don't have a hangover, just high BP and this comes with (produces?) fatigue. I think it produces fatigue because the system has worked very hard to digest, while it should be recuperating, so it leaves the body drained.

It seems fairly clear with a number of us here that our BP is high in POIS. So I ask? Why? Might this not be a clue as to what might be going on? Adrenalin or related family would only cause a temporary rise in BP, maybe 1 hr. High BP can be related to liver function.

[demografx]

Demo you said in the past you were severely depressed and that Prozac helped you a lot. Do you think your depression was caused by POIS ? Maybe SSRIs can help to reduce (not cure) POIS as Dr Waldinger and the Dr from the New York Times article are saying.

Also I was wondering, what are the positive effects of testosterone on your mental (memory, anxiety, optimism, other ?), and on feeling of physical fatigue.
Thanks in advance.

Martin, that has been a fascinating question for me, for many years! ("Did POIS cause your depression?") The truth is...I don't know!! But this I do know: Prozac pulled me out of "the snakepit" of depression, i.e., I was lifted from the very WORST nightmare symptoms, but still periodically I fell into depressed moods.

Testosterone has lifted my mood, energy, given me strength and, of course, drastically improved my POIS. the "Catch 22" of TRT is that it has increased my libido, and I will leave to your imagination the implication of that : - )

I just saw my urologist (my endo is out for now because of changing insurance), and he said that I am in "the lower 1/3" of testosterone levels. But I won't try to change that because that would heighten libido again, while most probably improving my POIS.

My problem remains with some POIS symptoms in the first hours to one day. But this is a HUGE relief from the 3-4 days of POIS agony for over 30 years!

Thanks for asking, Martin.

[demografx]

daveman and others following the BP chat, one thing I notice about BP is that it's still high (but med-controlled) since my open heart surgery 4 months ago, quintuple bypass.

But my energy level, mood, and overall well being has increased dramatically!

It makes me wonder, if proper blood flow, better circulation of oxygen after bypass, if BP is only one piece of the puzzle? POIS has remained about the same. If I'm careful with frequency, my POIS symptoms are about 90% relieved. I've cut back even further on low-dose stimulants though.

Let's get a med researcher over here already!!!  : - )

[daveman]

daveman and others following the BP chat, one thing I notice about BP is that it's still high (but med-controlled) since my open heart surgery 4 months ago, quintuple bypass.

But my energy level, mood, and overall well being has increased dramatically!

It makes me wonder, if proper blood flow, better circulation of oxygen after bypass, if BP is only one piece of the puzzle? POIS has remained about the same. If I'm careful with frequency, my POIS symptoms are about 90% relieved. I've cut back even further on low-dose stimulants though.

Let's get a med researcher over here already!!!  : - )

If we are around 1/4 of a percent of the population, there's gotta be one or two out there!!

On the BP, I think it's like you say, the "new heart" has improved "the energy level, mood, and overall well being", more oxygen and circulation, but the BP has remained relatively constant.

I think you might expect that if the BP was caused by something else, like who knows, POIS, liver, genetics....

I ignored the BP stuff initially because I've had it for quite some time and have seen it as not POIS related. Several things can trigger my BP, like, as I mentioned, bad eating habits and coincidentally, orgasms. I don't consider transient effects that last for an hour or so as BP events, most people have transient BP rises associated with certain activities (sex and orgasm one of those).

But this last event of mine has made me think twice. For me it triggered a BP event of around 20 hrs. For those of us who suffer BP rises during POIS I would conjecture that it is more than transient.

On the one hand it could be as you say, "just one piece of the puzzle". But is it a piece of the blue sky or is it a piece of the main character's face? Why for instance, does it trigger my BP for 1 to several days? Very little else does, even though I'm cronic.

I guess that med researcher could have some ideas as to why...

[Defsync]

Anyone who knows the answer: Other than what's described by a doctor in the first page of this thread, did any of you try drugs that increases the dopamine levels in the brain (I think such a drug is Wellbutrin)? For how long have you tried it? did it help?

Also - did any of you tried drugs that increases levels of noradrenaline (also known as norepinephrine)? For how long? Did it help?
On that matter I have to say that I'm taking Cymbalta (which is an Serotonin Norepinephrine re-uptake inhibitor, and therefore should elevate levels of norepinephrine in the brain), 60 mg a day for about 7-8 months now, and it doesn't really seem to help.

I have my eyes on especially on dopamine, and want to see if you had some experience with it.

tbqh, ive tried Adderall, Wellbutrin, Dexedrine, tobacco, none of which has directly helped POIS symptoms, although the 2 ADD meds do eliminate anxiety if thats a problem for you. this is what lead me to believe my POIS  is not an affect of dopamine or the lack thereof.

[demografx]

daveman, thanks, you've made me think some more about the relationship between BP and POIS. It's become pretty obvious to me since you pointed it out. I wasn't aware of the possible connection, but now I am thanks to your posts, and others', and my recent surgery, which has forced me to monitor BP much more than ever before.

I hope we can hear from more forum members about this.

[martin88]

Daveman, I have severe physical fatigue when I'm in POIS, and normal BP (or slightly hypo). Probably so many sensitivities for one cause!

Testosterone has lifted my mood, energy, given me strength and, of course, drastically improved my POIS. the "Catch 22" of TRT is that it has increased my libido, and I will leave to your imagination the implication of that : - )

I just saw my urologist (my endo is out for now because of changing insurance), and he said that I am in "the lower 1/3" of testosterone levels. But I won't try to change that because that would heighten libido again, while most probably improving my POIS.

My problem remains with some POIS symptoms in the first hours to one day. But this is a HUGE relief from the 3-4 days of POIS agony for over 30 years!

Thanks Demo. I have the same reaction, when libido is high my mood is always better. However I can be bothered by this sometimes, specially when there's no feeling of control (premature ejaculation).
I'm still hesitant to go through T therapy (stopping irreversibly my own T production,etc...). At least you feel sperm production is increased, it's a proof testicles (or a part) are still functioning.
You said you were improved with a nap:
Growth hormone is secreted during a nap, and involved in sperm production. Maybe something to study..

[Defsync]

related memory problems:

ive always had a horrible time with memory recall. which of course makes conversation a bit difficult, amongst other things. but i am able to recognize anything ive experienced if its presented. like i can hear 2 seconds of a song and be able to recognize it, although i couldnt tell you the name of the song or who its by. this tells me i am able to internalize experiences into memory storage, but recalling them at will is incredibly difficult.

my grandfather had progressing Alzeihmer's disease, and would have reached stage 3 if he didnt die from heart failure. do genetics play a part?

i wonder if my POIS isnt a symptom of a specific orgasm related function, but rather there is a deficiency / messed up physical structure elsewhere in my brain that, when I "O", whereas a normal person's brain can compensate for the neuro-chem cocktail released into the system, mine cannot.

its like you are driving down the road in a big steel car, say a cadillac. this is a normal person. you get into a wreck (the "O") and the driver is fine because of the solid metal frame.

i, on the other hand, am driving down the road in a ford festiva or other small compact car made out of aluminum and plastic. i get into a wreck (the "O") and the driver is severely wounded.

i also want to point out if you do get an MRI, be careful of what is ordered. I recently have noticed with my brain MRI, only 24 snapshot (slides) were taken of the sagittal plane. thats almost one snapshot every 1 cm.

1 cm huh? yeah i dont know what they expected to learn with 1cm gaps between each pic. on the net i see MRIs of ppl's brains with at least twice that many snapshots. all im suggesting is ask the doc about the number of snapshots saggital / axial planned for your MRI to ensure their are ENOUGH for a proper assessment.

[Z_one]

Hi all,

Just want to report that Sasparilla, Maca and Rhodiola have not been effective in curing my POIS despite their many biologiocal benefits....
On the other hand, Damiana, nigella Sativa & recently Astralagus have greatly reduced my symptoms by at least 80% but without curing POIS......I'll be trying some new herbs during the next couple of weeks with the hope of finding nature's cure....meanwhile I'll be renewing some new tests  including :


•   Possible deficiency or excess in on or more neurotransmitters. 

•   One or more neurotransmitter acting as an antibody and triggering an autoimmune reaction

•   A hormonal imbalance leading to the symptoms upon a sexual activity.
•   Hypothalamus-pituitary-adrenal disorder.
   
•   A pre-existing STD which worsen sexual recovery and leads to the symptoms.

Full spectrum of tests before and after POIS & projected over three to four days.
Trial of an immunosuppressant to see if symptoms disappear.
To also be included in tests: Blood pressure monitoring + Cortisol levels. 

Will keep you posted.

[demografx]

You said you were improved with a nap:
Growth hormone is secreted during a nap, and involved in sperm production. Maybe something to study..

Thanks, Martin, I didn't realize that!

[demografx]

Question

Responding to many forum members' growing impatience and frustration about moving forward in POIS research: I'd like to approach my famous endo and ask him to recommend his brightest graduate student to review our posts and make recommendations. It can't cost us much (I would ask those who have pledged research funds here for POIS to fund this).

Any thoughts, comments, opinions?

[Defsync]

Question

Responding to many forum members' growing impatience and frustration about moving forward in POIS research: I'd like to approach my famous endo and ask him to recommend his brightest graduate student to review our posts and make recommendations. It can't cost us much (I would ask those who have pledged research funds here for POIS to fund this).

Any thoughts, comments, opinions?

sounds good. also, i dont know how this would be done, but dont they have "medical conventions" around the nation about a variety of different pathologies? I wonder what it would take to get POIS noticed by an organization running such a convention (sexual / neurological). Maybe even getting a letter to them, saying "during your convention, could you make a short announcement about POIS and where to go (here) to find more information?"

[daveman]

sounds good. also, i dont know how this would be done, but dont they have "medical conventions" around the nation about a variety of different pathologies? I wonder what it would take to get POIS noticed by an organization running such a convention (sexual / neurological). Maybe even getting a letter to them, saying "during your convention, could you make a short announcement about POIS and where to go (here) to find more information?"

There must be a lot more people to reach! I was crunching the numbers, and if 1/4 percent is right, and then 50% males, the US alone should have 386000 male POIS sufferers! So that should have some interest to doctors and medical supply people.

[Limejuice]

Daveman, I believe the estimate is 1/4 of a percent or .0025.  Worldwide that is many people.

[prism]

but theres never been even one book written about it, got to be very obscure.

[demografx]

Daveman, I believe the estimate is 1/4 of a percent or .0025.  Worldwide that is many people.

Limejuice, I'm not sure anyone really knows, especially considering all the "closet POISers", who, because of the potential stigma surrounding the subject of sex and sexual disorders, are afraid to broach the subject with the outside world.

And then there is a sizable group, I imagine, who haven't even connected POIS to sex, especially with the delay of symptom onset that is common for so many people.

In addition to all the people who have either posted here, or PMed me privately, I can certainly vouch for myself as being in both of the above groups at one time or another!

[demografx]

Just want to report that Sasparilla, Maca and Rhodiola have not been effective in curing my POIS despite their many biologiocal benefits....

On the other hand, Damiana, nigella Sativa & recently Astralagus have greatly reduced my symptoms by at least 80% but without curing POIS......I'll be trying some new herbs during the next couple of weeks with the hope of finding nature's cure....meanwhile I'll be renewing some new tests 

.........Will keep you posted.

Many thanx, Z_One!

[demografx]

related memory problems:

ive always had a horrible time with memory recall. which of course makes conversation a bit difficult, amongst other things. but i am able to recognize anything ive experienced if its presented. like i can hear 2 seconds of a song and be able to recognize it, although i couldnt tell you the name of the song or who its by. this tells me i am able to internalize experiences into memory storage, but recalling them at will is incredibly difficult.

my grandfather had progressing Alzeihmer's disease, and would have reached stage 3 if he didnt die from heart failure. do genetics play a part?

i wonder if my POIS isnt a symptom of a specific orgasm related function, but rather there is a deficiency / messed up physical structure elsewhere in my brain that, when I "O", whereas a normal person's brain can compensate for the neuro-chem cocktail released into the system, mine cannot.

its like you are driving down the road in a big steel car, say a cadillac. this is a normal person. you get into a wreck (the "O") and the driver is fine because of the solid metal frame.

i, on the other hand, am driving down the road in a ford festiva or other small compact car made out of aluminum and plastic. i get into a wreck (the "O") and the driver is severely wounded.

i also want to point out if you do get an MRI, be careful of what is ordered. I recently have noticed with my brain MRI, only 24 snapshot (slides) were taken of the sagittal plane. thats almost one snapshot every 1 cm.

1 cm huh? yeah i dont know what they expected to learn with 1cm gaps between each pic. on the net i see MRIs of ppl's brains with at least twice that many snapshots. all im suggesting is ask the doc about the number of snapshots saggital / axial planned for your MRI to ensure their are ENOUGH for a proper assessment.

Interesting, Defsync! I could have used this last year when I did an MRI of the brain (pituitary).

[demografx]

Horny Goat Weed

Some of you who were here a while back might remember the discussions about this herbal medicine that researchers in Italy analyzed. So I almost bought this drink today at an upscale food store!
http://uspfb.com/adult.shtml


Here are our previous discussions about HGW:
http://www.google.com/#hl=en&rlz=1W1DAUS_en&q=horny+goat+weed+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&aqi=&aql=&oq=&gs_rfai=&fp=9118ce00d2daff08

[demografx]

the US alone should have 386000 male POIS sufferers! So that should have some interest to doctors and medical supply people.

Sadly, the medical industry is only interested in millions, preferably tens of millions. []