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Quote from: lauracostis on 23/01/2011 22:36:54Quote from: daveman on 23/01/2011 19:05:03Back in August we talked about the potential for the male anti-consceptive!! This now seems like a VERY good option for a quicker solution to the allergy problem.The product stops the production of sperm by tricking the system into thinking that the coffers are full. A subtle and not even potent combination of testosterone and progesterone. Similar to, but different than TRT that replensihes the coffers quickly (like Demo's case).Could it be that TRT produces levels enough to prevent sperm production all together?Or could it be that TRT produces full and complete "O"s more cosnsitently therefore exposing the system to lesser pressures and residues that cause leakage in "the gap".I say this because as we have recently said. Some of us have epxerienced shorter POIS sessions with full and complete "O"s. If there's a gap and no backpressure but good flow through, perhaps the leakage is limited. And in some the gap may require greater pressures to produce "leakage". It IS strange, but if all the ducks are lined up right, and there's also a "push" through the orgasm, one might think that there'd be more pressure. But you can feel when it's good, it flows cleanly despite the pushing.If the p3n1s is soft and doubled-up, it doesn't flow, there's much more internal pressure and the back-flow stays inside.Just a couple of ideas on why TRT might work!the male contraceptive treatment that i proposed with progesterone and testosterone only stops the production of sperm and also some other hormones that are associated with their production. Dr. Waldinger did his experiments with semen because he does not have the resources to separately test all the components of semen. i can only imagine that sperm would be the most likely part of semen to cause a reaction. the male contraceptive would be an excellent start for someone to see if sperm and the neuro-endocrine chemicals associated with their production are causing are problem. All the studies i read said the treatment is safe and that no side effects were reported at all, which is quite unbelievable. the only problem is that there is no pill made for the male contraceptive that is out on the market yet. You would have to go see and endocrinologist and he would prescribe two prescriptions for progesterone and testosterone that you would have to take together. I have an study that shows many of the different hormone combination that have been tried and the results as they apply to stopping sperm production. what happens when your on the treatment is that when you ejaculate semen comes out, but no sperm. for anyone who does not know the difference, sperm are the little critters from your testis that swim and make a girl pregnant. semen is a mixture of sperm with other fluids, your semen on the treatment will be absent of of sperm. it is sperm antibodies that can result from a vasectomy and not semen anti bodies. I agree that it's quite possible that we may be allergic to some other component.In my case I would be tempted to think that it is sperm, because it is very very likely I have heavy anti-bodies to sperm.I'm not sure how easy it may be to find someone in Chile willing to make the combination, but I would probably start with my reversal doctor. He's a urologist, specializing in micro-surgery.... but with knowledge of course of the workings of the immunological functions involved. Not sure if he forsaw the systemic wide potential for the allergy however....Anyways, would it be possible to PM me some of the data you speak of so I can present it to him? I'll bring copies of the Dr. Waldinger papers as well. I think he may well be very prepared to accept the report, as he made similar warnings to me at the time of the reversal, (about sperm anti-bodies and damage to plumbing as a result of reactions with them... no mention of POIS though).I'm not sure if some fear of liability might cause him to just play dumb however.... we'll have to see how it goes.
Quote from: daveman on 23/01/2011 19:05:03Back in August we talked about the potential for the male anti-consceptive!! This now seems like a VERY good option for a quicker solution to the allergy problem.The product stops the production of sperm by tricking the system into thinking that the coffers are full. A subtle and not even potent combination of testosterone and progesterone. Similar to, but different than TRT that replensihes the coffers quickly (like Demo's case).Could it be that TRT produces levels enough to prevent sperm production all together?Or could it be that TRT produces full and complete "O"s more cosnsitently therefore exposing the system to lesser pressures and residues that cause leakage in "the gap".I say this because as we have recently said. Some of us have epxerienced shorter POIS sessions with full and complete "O"s. If there's a gap and no backpressure but good flow through, perhaps the leakage is limited. And in some the gap may require greater pressures to produce "leakage". It IS strange, but if all the ducks are lined up right, and there's also a "push" through the orgasm, one might think that there'd be more pressure. But you can feel when it's good, it flows cleanly despite the pushing.If the p3n1s is soft and doubled-up, it doesn't flow, there's much more internal pressure and the back-flow stays inside.Just a couple of ideas on why TRT might work!the male contraceptive treatment that i proposed with progesterone and testosterone only stops the production of sperm and also some other hormones that are associated with their production. Dr. Waldinger did his experiments with semen because he does not have the resources to separately test all the components of semen. i can only imagine that sperm would be the most likely part of semen to cause a reaction. the male contraceptive would be an excellent start for someone to see if sperm and the neuro-endocrine chemicals associated with their production are causing are problem. All the studies i read said the treatment is safe and that no side effects were reported at all, which is quite unbelievable. the only problem is that there is no pill made for the male contraceptive that is out on the market yet. You would have to go see and endocrinologist and he would prescribe two prescriptions for progesterone and testosterone that you would have to take together. I have an study that shows many of the different hormone combination that have been tried and the results as they apply to stopping sperm production. what happens when your on the treatment is that when you ejaculate semen comes out, but no sperm. for anyone who does not know the difference, sperm are the little critters from your testis that swim and make a girl pregnant. semen is a mixture of sperm with other fluids, your semen on the treatment will be absent of of sperm. it is sperm antibodies that can result from a vasectomy and not semen anti bodies.
Back in August we talked about the potential for the male anti-consceptive!! This now seems like a VERY good option for a quicker solution to the allergy problem.The product stops the production of sperm by tricking the system into thinking that the coffers are full. A subtle and not even potent combination of testosterone and progesterone. Similar to, but different than TRT that replensihes the coffers quickly (like Demo's case).Could it be that TRT produces levels enough to prevent sperm production all together?Or could it be that TRT produces full and complete "O"s more cosnsitently therefore exposing the system to lesser pressures and residues that cause leakage in "the gap".I say this because as we have recently said. Some of us have epxerienced shorter POIS sessions with full and complete "O"s. If there's a gap and no backpressure but good flow through, perhaps the leakage is limited. And in some the gap may require greater pressures to produce "leakage". It IS strange, but if all the ducks are lined up right, and there's also a "push" through the orgasm, one might think that there'd be more pressure. But you can feel when it's good, it flows cleanly despite the pushing.If the p3n1s is soft and doubled-up, it doesn't flow, there's much more internal pressure and the back-flow stays inside.Just a couple of ideas on why TRT might work!
Quote from: Guthrie on 23/01/2011 22:48:08One thing which I may have mentioned before, but which may have new relevance in light of Dr. Waldinger's studies, is the fact that, when I am in POIS, I notice that the force of my urine stream is considerably weaker, as compared to when I am out of POIS.Same symptom for me, usually very mild. Always only in the morning immediately after I wake up. However recently (maybe 2 months ago) I started to take 200IU vit D, 3X/day, and it was VERY aggravated. Then when I stopped vitamin D all came back like before. I don't know if it's just a coincidence...I think it was prostate related, even if I'm only 40.
One thing which I may have mentioned before, but which may have new relevance in light of Dr. Waldinger's studies, is the fact that, when I am in POIS, I notice that the force of my urine stream is considerably weaker, as compared to when I am out of POIS.
Quote from: demografx on 23/01/2011 23:40:09Quote from: kristy on 23/01/2011 23:11:07Can anyone help an idiot and PM me how to print off the PDF files so I can take/send them to my Doctor please I've got no idea when it comes to computers.Decided I'm going to give it another go with him, if he still takes no notice after reading the reports then I'll change Doctors.Thanks Maybe someone can fax it to you? (My fax is down).Kristy, you can also email it to your local Fedex Office and they can print it out for you.
Quote from: kristy on 23/01/2011 23:11:07Can anyone help an idiot and PM me how to print off the PDF files so I can take/send them to my Doctor please I've got no idea when it comes to computers.Decided I'm going to give it another go with him, if he still takes no notice after reading the reports then I'll change Doctors.Thanks Maybe someone can fax it to you? (My fax is down).
Can anyone help an idiot and PM me how to print off the PDF files so I can take/send them to my Doctor please I've got no idea when it comes to computers.Decided I'm going to give it another go with him, if he still takes no notice after reading the reports then I'll change Doctors.Thanks
daveman, speaking as a guinea pig, I can say that stopping production of sperm alone did not end all of my POIS symptoms. It did improve them a little though. I really needed to stop all semen production entirely to cure my POIS. Just thought you might like to know. Hopefully somebody will find a way to cure it without making that necessary.
Male Contraceptives- Different types in developmentFrom http://en.wikipedia.org/wiki/Male_contraceptivePharmaceutical methodsOne goal of research is to develop a male oral contraceptive, a male contraceptive that can be taken in pill form by mouth, as The Pill was for women. Calcium channel blockers such as nifedipine may cause reversible infertility by altering the lipid metabolism of sperm so that they are not able to fertilize an egg.[18] Recent Research at Israel’s Bar-Ilan University show that as of June 2010, such a pill may be 5 years away. Testing it the pill on Mice has been found to be effective, with no side effects[19] Adjudin, a non-toxic analog of lonidamine which, in tests on rats, has been shown to cause reversible infertility.[20] The drug disrupts the junctions between nurse cells (Sertoli cells) in the testes and forming spermatids. The sperm are released prematurely and never become functional gametes. A new targeted delivery mechanism has made Adjudin much more effective.[21] Multiple male hormonal contraceptive protocols have been developed. One is a combination protocol, involving injections of Depo-Provera to prevent spermatogenesis, combined with the topical application of testosterone gel to provide hormonal support.[22][23] Another is a monthly injection of testosterone undecanoate, which recently performed very well in a Phase III trial in China.[24][25] Research has been performed on interference with the maturation of sperm in the epididymis.[26][27] Phenoxybenzamine has been found to block ejaculation, which not only gives it the potential to be an effective contraceptive, but could also lead to much cleaner sex. Studies have found that the quality of the semen is unaffected and the results are reversible by simply discontinuing the treatment.[28] Silodosin, an α1-adrenoceptor antagonist with high uroselectivity, has been shown to completely block ejaculation in human males while permitting the sensation of orgasm.
Quote from: demografx on 24/01/2011 01:48:37Quote from: demografx on 23/01/2011 23:40:09Quote from: kristy on 23/01/2011 23:11:07Can anyone help an idiot and PM me how to print off the PDF files so I can take/send them to my Doctor please I've got no idea when it comes to computers.Decided I'm going to give it another go with him, if he still takes no notice after reading the reports then I'll change Doctors.Thanks Maybe someone can fax it to you? (My fax is down).Kristy, you can also email it to your local Fedex Office and they can print it out for you.Or take the files to a local cyber-cafe, they can print them
Quote from: daveman on 24/01/2011 11:22:53Quote from: demografx on 24/01/2011 01:48:37Quote from: demografx on 23/01/2011 23:40:09Quote from: kristy on 23/01/2011 23:11:07Can anyone help an idiot and PM me how to print off the PDF files so I can take/send them to my Doctor please I've got no idea when it comes to computers.Decided I'm going to give it another go with him, if he still takes no notice after reading the reports then I'll change Doctors.Thanks Maybe someone can fax it to you? (My fax is down).Kristy, you can also email it to your local Fedex Office and they can print it out for you.Or take the files to a local cyber-cafe, they can print themYou need to download the Adobe Reader- which is able to open up the PDF files and print them. It's a free program:http://get.adobe.com/reader/
Quote from: horizon on 24/01/2011 16:11:42Male Contraceptives- Different types in developmentFrom http://en.wikipedia.org/wiki/Male_contraceptivePharmaceutical methodsOne goal of research is to develop a male oral contraceptive, a male contraceptive that can be taken in pill form by mouth, as The Pill was for women. Calcium channel blockers such as nifedipine may cause reversible infertility by altering the lipid metabolism of sperm so that they are not able to fertilize an egg.[18] Recent Research at Israel’s Bar-Ilan University show that as of June 2010, such a pill may be 5 years away. Testing it the pill on Mice has been found to be effective, with no side effects[19] Adjudin, a non-toxic analog of lonidamine which, in tests on rats, has been shown to cause reversible infertility.[20] The drug disrupts the junctions between nurse cells (Sertoli cells) in the testes and forming spermatids. The sperm are released prematurely and never become functional gametes. A new targeted delivery mechanism has made Adjudin much more effective.[21] Multiple male hormonal contraceptive protocols have been developed. One is a combination protocol, involving injections of Depo-Provera to prevent spermatogenesis, combined with the topical application of testosterone gel to provide hormonal support.[22][23] Another is a monthly injection of testosterone undecanoate, which recently performed very well in a Phase III trial in China.[24][25] Research has been performed on interference with the maturation of sperm in the epididymis.[26][27] Phenoxybenzamine has been found to block ejaculation, which not only gives it the potential to be an effective contraceptive, but could also lead to much cleaner sex. Studies have found that the quality of the semen is unaffected and the results are reversible by simply discontinuing the treatment.[28] Silodosin, an α1-adrenoceptor antagonist with high uroselectivity, has been shown to completely block ejaculation in human males while permitting the sensation of orgasm. The third option Multiple male hormonal contraceptive is the one I think we discussed here most predominantly. This method prevents spermatogenesis altogether, which would be the best option in the case of potential sperm allergy. However if it is an allery to other components of the semen.....Calcium channel blockers and Adjudin permit sperm production although the sperm may be non-viable, however it may not guaranttee prevention of allergy because valid sperm material is present.The last two... who knows. They seem to function in a manner similar to a vasectomy in that seminal material doesn't leave the system. Could be good options. With Silodosin it mentions specifically that one does not loose the effect of the orgasm.
Calcium channel blockers and Adjudin permit sperm production although the sperm may be non-viable, however it may not guaranttee prevention of allergy because valid sperm material is present.
Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks.
I just wrote to Dr Christina Wang, one of the principal investigators of the male contraceptive study, to see what their status is. (Started in May, 2010 with a $1.5 million grant).
Quote from: Animus on 24/01/2011 21:28:25Hi, Can anyone tell me if we still have a world map of the members on the Forum? I remember someone started that not too long ago. I'm really interested to start a local, San Francisco support group, and would like to contact other members in this area. Also, please contact me if you're in California, or on the West Coast. Thanks. http://sites.google.com/site/poiswebsite/pois-mapPM "mat780" for more details.