[kurtosis]

Anyone tried Vinpocetine? It's supposed to have direct cerebral vasodilatory and incremental blood flow features

Yes.  it might help you marginally, but not significantly.  I've tried many different smart drugs, and ginkgo biloba is the most helpful of the batch.

i did  to and it didnt help.

Ginkgo has helped me at 240mg / day  with 120mg taken in the morning and 120mg in the afternoon. I'm in agreement with the spoof article that was posted. I have no idea who posted it but I don't think POIS is a single disease either so what works for one person doesn't necessarily work for someone else.

[Habibou]

I answered to the questionnaire !
a good help from this doctor to collect info like that It takes 5 minutes and maybe it can bring us something positive so take this time to help us.

[B_Daniel]

I answered the questionnaire too.  It's nice to see a doctor take interest in us.  Thanks Observer.

[Prancer]

K, I also answered the survey. The main reason I'm posting though is because I found something interesting. So, a while back I talked about ways one can lower his libido to avoid having too many orgasms, and I gave a link to a site I found called "eunuch.org". People there basically desire to live as a eunuch (I think). But while reading through some posts I found an interesting one that relates to POIS. (http://www.eunuch.org/forums/showthread.php?22847-Testosterone-changed-my-gender-and-eliminated-the-desire-for-castration)

It is the first post (the long one) by user "guy26". What really got my attention was point #11 from the first post by the user. He talks about TAKING testosterone rather than eliminating it. Have we found another case like demografx where testosterone completely cured POIS?

The quote is:

Immediately following the most intense orgasms, I feel tremendously bad. Not just a little bad, but REALLY bad and in a way that is hard to articulate. It's like being hit with a hammer, but without the pain. It has nothing to do with feeling ashamed, embarrassed, or any other reasonable explanation that would come to mind. It has happened many times over the years. And this bad feeling would last 30 minutes to an hour and then mysteriously disappear. It has been so intense at times that I would take a shower and cry uncontrollably. Some people call this problem Post Orgasmic Illness Syndrome (POIS), which can also have other symptoms. It has only recently being studied and I haven't been diagnosed with it. But I have no better name to call it.

Anyway, one of the most surprising side effects of taking testosterone is that I have not had this happen! Initially when I started taking testosterone it made my climaxes MUCH stronger than on average. The first time it happened I just KNEW that I was going to feel like crap. It didn't happen. Then over the next week I climaxed several times and hard enough that it should have easily caused the problem. But nothing happened. I have absolutely no idea why this problem seems to be totally gone, but I am very thankful!

So yeah, I just thought it was interesting because it might be another testosterone cure case. He describes other symptoms it helped too, like the fact it made him "feel more like a guy" instead of a neutral gender, that it removed his sensitivity to cold (something I might have), increased his appetite, and made him feel more peaceful. Maybe someone can somehow bring/ask him over to this forum one day so he can talk about what he did. He seems like he doesn't mind talking about it.

[B_Daniel]

that's somewhat comical to think about a guy on a eunuch website talking about how hard his orgasms are.  Seriously though, he definitely has POIS and it sounds like Testosterone works for him.  Prancer, invite him over here! 

There seems to be a growing amount of evidence that our POIS has a hormonal component.  Given that many of our POIS symptoms stem from the low dopamine state that POIS places us in, a hormonal imbalance that then affects our dopamine levels makes sense.  Dopamine and Testosterone are tightly linked, so it's no surprise that testosterone replacement can raise dopamine and relieve some/all of our POIS.  That  said, I tried T for 6 months and it didn't work for me.  There are other hormones which are directly tied to dopamine though, and I think this should be an active area of research for all of us.  In Dr Dexter's study, an individual was successfully treated with progesterone.  I'll point out here that I've been on Progesterone for about a week and have not felt improvement, but am hopeful I'm on the right path.   

[Prancer]

Prancer, invite him over here!   

Ok, I sent him an email after signing up over there. He hasn't been active for a few months it looks like, but we'll see what happens!

Also, I'm sorry to hear that the progesterone hasn't been working for you. Maybe it takes a little longer to start having an effect. I know POIS is very tough and want you to feel heathly again ASAP. Keep us updated!

(As a side note, I've been abstaining for about a week now, and I feel a little better. I am traveling from the 10th-20th from Miami to Baltimore and need to be as clear minded as possible during this trip. If I can, I'm going to keep the abstaining going for as long as possible even when I return to see what happens and how I feel.)

[Omen 30]

I think we are all facing the early signs of demetia,maybe alzeimers and post orgasm is one of the symptoms.pls check for any hereditary link,I have it.

[gondal4]

I have POIS since 6 years,im 25 years old firstly it was like fatigue,leg pain,joint pain,then i had hepatitis A which lasted 3,4months  caused me severe general weakness .
After that whenever i ejaculate i get very weak in abdomen severly weak cannot travel in car due to pain in abdomen for 4,5 days and genrally my abdomen has become very week.When i was 13 i got  hit in testicles resulted in severe swelling and blood still left in testes.

[kurtosis]

I think we are all facing the early signs of demetia,maybe alzeimers and post orgasm is one of the symptoms.pls check for any hereditary link,I have it.

Perhaps but
1) daveman and demo have had it for a while without actually becoming demented
2) it doesn't show up on MRI's. I'm in my mid 30s and have had 2 MRI's. Both neurologists couldn't find any sign of lesions or obvious reduction in brain tissue.
They said that if there was a problem it was either to do with transmission of nerve impulses (neurotransmitters etc.) or some form of chronic anxiety disorder. It didn't occur to them that you could have an anxiety problem mediated by a physiological issue (i.e. the body just producing too much stress hormones). Anyway, it's nice to know that I still have a brain and have the pictures at home to prove it

[Prancer]

Ok, the user that I found, guy26, has come over to the other forum to talk about his cure. He says he is open to answer any questions if there are any.

[Omen 30]

After staying away from O I have noticed that even little love making with wife or a little less sleep is giving me pois, but the symptoms last less around a day.the new symptoms I have noticed are diarhea(loose motions),fungal infection in groin area.I think pois is attacking the immune system.

[kurtosis]

After staying away from O I have noticed that even little love making with wife or a little less sleep is giving me pois, but the symptoms last less around a day.the new symptoms I have noticed are diarhea(loose motions),fungal infection in groin area.I think pois is attacking the immune system.

I absolutely think so too. Check out the new discussion on dopamine and dopac on poiscenter.com

[Habibou]

ONLY Urina test, morning 10 hours after an O:

DOPA                       91.50ug/g     (160 - 240)
34DOPAC                  0.40 mg/g   (0.70 - 4.00)
HVA                          1.90 mg/g    (2.43 - 5.20)
NORADRENALIN          10.30 ug/g  (15.70 - 34.30)
MHPG                          1.50 mg/g  (1.38 - 4.15)
VMA                            1.60 mg/g  (2.10 - 3.85)
ADRENALIN                  0.98  ug/g  (1.27 - 6.10)
SEROTONIN                62.40  ug/l   (61.50 - 116.80)
5HIAA                        2.30    mg/g (2.03 - 4.26)
HVA5HIAA                  0.83            (1.25 - 2.56)

[mat780]

ONLY Urina test, morning 10 hours after an O:

DOPA                       91.50ug/g     (160 - 240)
34DOPAC                  0.40 mg/g   (0.70 - 4.00)
HVA                          1.90 mg/g    (2.43 - 5.20)
NORADRENALIN          10.30 ug/g  (15.70 - 34.30)
MHPG                          1.50 mg/g  (1.38 - 4.15)
VMA                            1.60 mg/g  (2.10 - 3.85)
ADRENALIN                  0.98  ug/g  (1.27 - 6.10)
SEROTONIN                62.40  ug/l   (61.50 - 116.80)
5HIAA                        2.30    mg/g (2.03 - 4.26)
HVA5HIAA                  0.83            (1.25 - 2.56)

Habibou,
Nice numbers! 

I would love to see the same test when you're out of POIS.

Regards,
Mat

[B_Daniel]

Habibou, I recently took a similar test, and likewise, I was in POIS at the time of the test.
I attached a jpeg of the results instead of typing all of it out.  If you believe it's all accurate, then the results are pretty shocking. 

[amijgoro]

Habibou, I recently took a similar test, and likewise, I was in POIS at the time of the test.
I attached a jpeg of the results instead of typing all of it out.  If you believe it's all accurate, then the results are pretty shocking.

I'm interested in knowing how you measured you'r neurotransmitters. was it a blood test? urin test? what do i ask for?

[B_Daniel]

Habibou, I recently took a similar test, and likewise, I was in POIS at the time of the test.
I attached a jpeg of the results instead of typing all of it out.  If you believe it's all accurate, then the results are pretty shocking.

I'm interested in knowing how you measured you'r neurotransmitters. was it a blood test? urin test? what do i ask for?

Mine was a urine test, with a company named Pharmasan Labs, Inc, which I think is the same as NeuroScience.  Honestly, I don't have a whole lot of faith in the test results.  Maybe they're accurate, but it just baffles me that none of my other psychiatrists thought to give me this if it indeed produces such accurate and telling data.  I'm not completely discounting it, but take it with a grain of salt.

All that said, I like the direction this forum is headed in, analyzing hormones and neurotransmitters more closely.  That seems to be where our problems lie.

[B_Daniel]

So I got all that testing done on my neurotransmitters, and you did too, Habibou.  Has anyone gotten a full Hormone analysis?  I had one done but results dont come back for another 2 wks

[aspagnito]

I am very sorry guys, but I think that whatever you do is just not right! All we here is an "neverending story" of a guys that has a headache after he masturbates. Go get Your life! If you have a problem with masturbating.. fine don't do that, but I am waiting for the Roman Catholic Church to say something real about it. This just doesn't mean, that as one gets the right kind of person, the headaches are gone, but (!)..
Here's the link, where You can find the truth:
https://www.facebook.com/remigiusz.fajfer?ref=tn_tnmn
and if You're really caucious, You'll find everything out there. That is oh so wrong to not speak about physics out here but about some dumb stuff.
I THINK! Scientist, nor the preachers should ever define sex, because it is a matter of our prime naivity to define that and every sex should be a teenagelike sex! Do the geno in gym and You won't get a brown-warm-discousting-in-your-mouth-sh-problem! You won't be saying that the Big-Bang is okay, but You will be sayin' it's a thing to believe when You got the Big-Dud problem.. and You'll splash particles on a bubble.

[Habibou]

Yes Daniel, we kind of have the same results...
OUT of POIS, it would be little better I guess but not a huge difference since I always have symptoms and brain fog, it because a CFS !