[B_Daniel]

I found this article fairly useful and explanatory for many hypothesis people here have proposed, after tons of search here n there I found this article to be the most cohesive in regard to relation between thyroid, disabilities, and POIS "Conclusion".

Learning Disabilities in Patients with Autoimmune Thyroid Disease and Their Families

http://www.thyroid.ca/e1b.php

I think it summarizes my case with POIS, and other problems.

Thanks for the 1st post, maradona, and welcome if you're new! 

i read through the article and nothing in it struck a chord with me.  i definitely don't have developmental dyslexia, white spots on the skin, prematurely graying hair, etc. 

[kurtosis]

That's really good Nathan.

This might work as it's a calcium channel blocker as well as a H1 anti-histamine.
I'm not sure if it will remove all the bad symptoms of an O but it should certainly reduce some. I don't get many bad headaches so I'm pretty convinced that my cognitive symptoms are primarily to do with the H3 histamine auto-receptors and the histamine released ANYWAY when we have an orgasm. Nothing to do with allergies to sperm, seminal fluid or anything like that.

If it doesn't work then you're on the right path and your doctor may be able to prescribe other histamine reducing / mast-cell stabilising medication. There's lots of recent posts on POISCenter about this.

from http://en.wikipedia.org/wiki/Flunarizine

Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with COMBOLMIN binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia. Flunarizine has been shown to significantly reduce headache frequency and severity in both adults and children. Flunarizine has some side effects including weight gain, extrapyramidal effects, drowsiness and depression, it is contraindicated in hypotension, heart failure and arrhythmia. Flunarizine use is avoided in patients with depression, severe constipation or those with extrapyramidal disorders. Flunarizine was discovered at Janssen Pharmaceutica in 1968.

[maradona]

I found this article fairly useful and explanatory for many hypothesis people here have proposed, after tons of search here n there I found this article to be the most cohesive in regard to relation between thyroid, disabilities, and POIS "Conclusion".

Learning Disabilities in Patients with Autoimmune Thyroid Disease and Their Families

newbielink:http://www.thyroid.ca/e1b.php [nonactive]

I think it summarizes my case with POIS, and other problems.

Thanks for the 1st post, maradona, and welcome if you're new! 

i read through the article and nothing in it struck a chord with me.  i definitely don't have developmental dyslexia, white spots on the skin, prematurely graying hair, etc.

Thanks for your attention : ) I've got tested for thyroid anti-bodies, and it returned negative. : P Now I'm confused for the underlying cause of my POIS. If it's autoimmune then what's getting attacked?

Information:
- I'm left handed


I've symptoms of mysterious illness that gets worsen by POIS:

1)Chronic 24/7 lightheadedness (like I'm not in reality) [Worsen without reaching orgasm, and become severe if reached]
2)Chronic dizziness (feeling off balance), very rare vertigo attacks (room spinning, not alleviated by laying down [By laying down headache like state persist, and gets relief by sleep] )
3)Overwhelmed by lights, people [Talking without appropriate thinking specially if information is extracted from memory], driving [Slow in taking action], movement, mental activity [Problem solving n puzzle like activities]
4)Physical activity (working out) makes me feel more lightheaded, more dizzy [ Dreamy state "Day Dreaming"]
5)Exhausted, burning eyes, light sensitivity "Photophobia" [Specially when using computers or cell phones], Drooping eyelid, Visual problems focusing [Specially when reading either a book, or from an screen monitor of any device]
7) Memory problems [Short term specially keeping up with high pace conversations arguing like conversations], and processing speed specially with math, and calculations. [Severe slow down occurs by POIS to a mental retardation level, and very low energy]
Depression for prolonged time



Others have it too
newbielink:http://www.medhelp.org/posts/Ear--Nose--Throat/Chronic-Lightheaded-Dizziness-Vertigo-Sensitivity-to-light-and-movement-Vestibular-Rehab/show/1001434 [nonactive]

[kurtosis]

I found this article fairly useful and explanatory for many hypothesis people here have proposed, after tons of search here n there I found this article to be the most cohesive in regard to relation between thyroid, disabilities, and POIS "Conclusion".

Learning Disabilities in Patients with Autoimmune Thyroid Disease and Their Families

http://www.thyroid.ca/e1b.php

I think it summarizes my case with POIS, and other problems.

Thanks for the 1st post, maradona, and welcome if you're new! 

i read through the article and nothing in it struck a chord with me.  i definitely don't have developmental dyslexia, white spots on the skin, prematurely graying hair, etc.

Thanks for your attention : ) I've got tested for thyroid anti-bodies, and it returned negative. : P Now I'm confused for the underlying cause of my POIS. If it's autoimmune then what's getting attacked?

Information:
- I'm left handed


I've symptoms of mysterious illness that gets worsen by POIS:

1)Chronic 24/7 lightheadedness (like I'm not in reality) [Worsen without reaching orgasm, and become severe if reached]
2)Chronic dizziness (feeling off balance), very rare vertigo attacks (room spinning, not alleviated by laying down [By laying down headache like state persist, and gets relief by sleep] )
3)Overwhelmed by lights, people [Talking without appropriate thinking specially if information is extracted from memory], driving [Slow in taking action], movement, mental activity [Problem solving n puzzle like activities]
4)Physical activity (working out) makes me feel more lightheaded, more dizzy [ Dreamy state "Day Dreaming"]
5)Exhausted, burning eyes, light sensitivity "Photophobia" [Specially when using computers or cell phones], Drooping eyelid, Visual problems focusing [Specially when reading either a book, or from an screen monitor of any device]
7) Memory problems [Short term specially keeping up with high pace conversations arguing like conversations], and processing speed specially with math, and calculations. [Severe slow down occurs by POIS to a mental retardation level, and very low energy]
Depression for prolonged time



Others have it too
http://www.medhelp.org/posts/Ear--Nose--Throat/Chronic-Lightheaded-Dizziness-Vertigo-Sensitivity-to-light-and-movement-Vestibular-Rehab/show/1001434

Why does anything have to be attacked? Some people produce many mast cells (http://en.wikipedia.org/wiki/Mastocytosis) . Some people produce too much immunglobulin. Some people have genetic mutations that prevent the effective methylation of histamine, meaning they have too high levels in their blood stream.
See http://www.csupharmacol.com/db/allpaper/117.pdf
and a possible connection to asthma. It's been theorised that a HNMT variation may increase the likelihood of schizophrenia.

Some could be infected by bacteria that produce histamine.

Vertigo in Meniere's disease is understood to be histamine related and is treated using a drug called
betahistine. http://en.wikipedia.org/wiki/Betahistine
Unfortunately, this is a h3 antagonist (good) and a histamine h1 agonist (potentially bad) so all bets are off as to how this would work on a POIS sufferer. More useful h3 antagonists should be available soon.

I first noticed POIS after an O when I was younger. The previous summer I had gotten bad food poisoning with symptoms that resembled http://en.wikipedia.org/wiki/Scombroid_food_poisoning
Histamine enables us to get an erection. It enables the body to have an orgasm and is released in large quantities during an O even if you have no evident allergies at all.

[steppenwolff]

First, let me say thank you all for existing.
2nd, I have heard a lot of people asking for things that help with the symptoms, without much luck. I have a few suggestions based on what I have learned from trial and error over 15 years.
Here is the short answer: specific mental activities that involve conceptualizing symbols, such as reading and math(the mental state that these activities require seems to counteract the mental effects of the condition for me). Diet is KEY: large doses of B6, B12, fish - especially what I think of fine-fiber fish, like shrimp, lobster, scallops, squid, mussels, etc. Chicken is ok. Whole wheat, especially oatmeal. I avoid crap food - fast food, processed meat, soda, deep fried stuff. Each of these things I mention because they have a noticeable effect on my energy.
I haven't read through all the posts, but there seems to me to be 2 different types - a short term and a long term bunch of symptoms. mine is the long term type. The onset is pretty much immediate - just a few minutes, and the effects are long lasting, but not as severe as some listed here. The mental and weakness last a month or more without the above stuff, but with the right diet and mental exercise, I can bring it down to a few weeks.
My physical symptoms include the light colored and loose stools - but seldom goes as far as diarrhea anymore - weakness, tiredness, eczema, excessive hunger, extreme reduction of the sensation of hunger (weird combination huh?), and of course sexual dysfunction.
Mental symptoms include general crankyness, difficulty finding words, lack of focus, problems with short term memory, 5 turtle doves, and a partridge in a pear tree.
I've had it for 15 yrs, I'm 35. It used to be so bad that I would collapse(slowly) on the carpet and lay there not exactly paralyzed, but not with enough energy to move. Its better now, but still a very frustratingly powerful force in my life.
I have an underactive thyroid, taking Levothyroxine.
I give enough blood to keep 3 vampires healthy - all my other hormone levels and other stuff is fine.
This is my first post, its late - I'll talk to you guys later.

[demografx]

As I mentioned, I have committed my time elsewhere, but that I would be checking in here from time to time.

I am really excited with all the progress. We are getting very close to the day when world-recognized, scientific-medical researchers will investigate our condition thoroughly and put us all in a better light. When we go for POIS treatment, we will have more respect and hopefully soon, some solid treatment recommendations.

Best wishes to all!

Happy New Year,
demo

[maradona]

Add to above posts that mentions appropriate medications, for me to get off depression and go to a good mental state

I take large amount of omega-3, and average amount of phosphatidylserine [Helps so much with mental problems in POIS, even If I can't take the right actions due to mental fog, I can still be somewhat calm]

Multivitamin INCLUDES: Zinc, Iodine, and the B vitamins family, Magnesium, Iron and the list goes on

Carnitine: Helps with memory a little


Lately I've started testing with DHEA, but now it's just few days to judge the results

[kurtosis]

Actually flunarizine dihydrochloride may block IgE regulated calcium channels and work as a mast cell stabiliser. I can well believe that this reduced the symptoms of POIS.
Some other things to try include methionine (reduce histamine through methylation) and DAOSin (reduce histamine using synthetic DAO in the gut).
The more I think about and research the high-histamine theory (and there's lots of info on poiscenter now) the more convinced I am that this is correct. We're suffering from an odd form of histamine intolerance because we either have too much histamine (for several possible reasons including infection, mastocytosis) or we can't clear it due to methylation or DAO synthesis issues.

[Starsky]

How to increase intestinal DAO without taking this enzyme?

[Coreman]

Dear Demografx and Others!


I’ve been having a BREAKTHROUGH  !!!
(Me: a member for 5 years, suffering from POIS for 10 years.)

To put it short, I’m diagnosed with Hyperprolactinaemia, taking pills and getting way better! 
   

http://en.wikipedia.org/wiki/Hyperprolactinaemia [nofollow]

The results of my lab tests:
(performed after a release):
Total Testo: 4,2 seriously under the range of 8,6 – 26
Prolactine:   1646 (!!) seriously over the range of 86-324

Taking Bromocriptine for 5 days, and feeling much better !!!

I met an Endocrinologist with profound knowledge.
->an adenoma tumour (so called prolactinoma) is suspected.
-> I am enlisted for an MRI test to check whether I really have prolactinoma. 

Cheers!! I’m over the moon now!

Coreman.

[Prancer]

That sounds like some pretty good news Coreman. Although it's early, I'm already getting excited! Please keep us up to date on any new developments. Thanks a lot and good luck!

- Prancer

PS: Let's give it the 2-week rule that B_Daniel suggested (wait couple weeks and see if you are still cured or feeling much better) before we really break out the champagne!

[kurtosis]

How to increase intestinal DAO without taking this enzyme?

Another way may be to look at methylation including supplementary methionine and or supplements containing methylfolate and methylcobalamin instead of their inactive un-methylated forms.

If people have genetic methylation problems, several will be revealed by a genetic test using well known services such as 23andme. I'm not promoting them, just making a statement of fact that there are some things we don't need to merely guess about

[Coreman]

That sounds like some pretty good news Coreman. Although it's early, I'm already getting excited! Please keep us up to date on any new developments. Thanks a lot and good luck!

- Prancer

PS: Let's give it the 2-week rule that B_Daniel suggested (wait couple weeks and see if you are still cured or feeling much better) before we really break out the champagne!

You're right, Prancer. Thanks! I'll give it a 2 weeks' go!
Coreman.

[nathan123]

Just an update,

It is after 14 days start taking the calcium channel blockers (Flunarizine hydrochloride). I have an o at the 10th day, 11th day, and 14th day (twice).  My all cognitive symptoms such as lack of mental clarity, Stammering, anxiety, difficulty in thinking, burning sensation are reduced extremely and presently running without Herbal life and Neem. Only taking the above medicine.  The only problem remaining is excess dreaming at night and abnormal breathing.

Hence, it is working superbly.  Now my social life has changing, I am calm, cool and started to present papers & seminars in office. My life totally changed.   I met doctor yesterday and he told that it is only 20 to 30% of recovery and it takes around 3 months for complete recovery from this.  But I am in a feeling that I have recovered 70% as my cognitive symptoms disappeared. 

Waiting in next 3 months, how my life will be after complete recovery.

Request you to consult your doctor and as per his guidance take the above mentioned tablet. Its working.  Initially I shared only herbal remedies with temprovery sucess and without scientific reason.  Finally I have shared my success with scientific medicine with reason for clear of POIS. 

My next proposed findings with the help of this forum and my doctor:
a) I want to know how the Testerone replacement theraphy reduce symptoms (cured)for demo and other person in this forum.  (What is the link between TRT and Calcium Channel Blocker)
b) What is the link between Niacin and Calcium Channel Blocker.
c) How Neem has stopped my POIS for 2 months and then how low diet food (without morning breakfast and dinner  and Herbal life) has helped me in some how temprovery blocking of POIS.

Please try this medicine for atleast 20 days (under guidance of doctor) and see the results.   Please don't expect result in first week. 

[elias miguel]

Firstly, thank God I found this forum, and thanks to you all who have posted here. Now I know I'm not alone! I have been wacking my brains wondering what's wrong with me. I mean I enjoy the orgasms, especially the deep, really explosive ones but now? Man! I can't burden the sickness after, the sadness after, the depression after, the "all the bad things"after. I even went to drinking to overcome my depression. And I could not tell anybody till this forum! So yeah, like most of you guys who have posted, I dread the very "after you shoot" fact. What good is having orgasm when you don't want to shoot or explode? And so, believe it or not, I tend to be "celibate" about it, until the proper and effective treatment is found or posted. I've tried so many things believe me: exercise, fish oil supplements, organic foods, name it -- I have tried it. The sad fact is being healthy men we need to have orgasms. And I certainly don't want to go through the rest of my life not having one or more or all of them or being afraid of having one or more or all of them. I read somewhere that Waldinger is coming soon or publishing a treatment for this. Meanwhile, I also read somewhere that using ProgestaCare for Men, or the Men's formula version of it, might or would work. Has anybody else heard of this? Again, thanks to all you guys. Just happy to be here and "suffer" with you and hopefully soon, "triumph" with you all. Cheers!

[kurtosis]

Just an update,

It is after 14 days start taking the calcium channel blockers (Flunarizine hydrochloride). I have an o at the 10th day, 11th day, and 14th day (twice).  My all cognitive symptoms such as lack of mental clarity, Stammering, anxiety, difficulty in thinking, burning sensation are reduced extremely and presently running without Herbal life and Neem. Only taking the above medicine.  The only problem remaining is excess dreaming at night and abnormal breathing.

Hence, it is working superbly.  Now my social life has changing, I am calm, cool and started to present papers & seminars in office. My life totally changed.   I met doctor yesterday and he told that it is only 20 to 30% of recovery and it takes around 3 months for complete recovery from this.  But I am in a feeling that I have recovered 70% as my cognitive symptoms disappeared. 

Waiting in next 3 months, how my life will be after complete recovery.

Request you to consult your doctor and as per his guidance take the above mentioned tablet. Its working.  Initially I shared only herbal remedies with temprovery sucess and without scientific reason.  Finally I have shared my success with scientific medicine with reason for clear of POIS. 

My next proposed findings with the help of this forum and my doctor:
a) I want to know how the Testerone replacement theraphy reduce symptoms (cured)for demo and other person in this forum.  (What is the link between TRT and Calcium Channel Blocker)
b) What is the link between Niacin and Calcium Channel Blocker.
c) How Neem has stopped my POIS for 2 months and then how low diet food (without morning breakfast and dinner  and Herbal life) has helped me in some how temprovery blocking of POIS.

Please try this medicine for atleast 20 days (under guidance of doctor) and see the results.   Please don't expect result in first week. 

Hi Nathan,
I've already explained the link. It's histamine. You're taking a histamine antagonist and calcium channel blocker. It's reducing the histamine production in your brain and blocking histamine's effects on h1 receptors.

Testosterone is an anti-inflammatory and may reduce histamine release. In people with high levels of histamine, the body has to produce cortisol in increasing amounts to manage inflammation and this reduces testosterone levels. TRT helps reduce inflammation, histamine and replenish depleted testosterone supplies.

Taking the anti-histamine with calcium channel blocking helps improve symptoms. Taking an anti-histamine with pseudo-ephedrine may improve symptoms. I'm improving symptoms by increasing methylation. The POIS reaction is all about the histamine.

There's lots of discussion on poiscenter about the relation between niacin, histamine and PGD2 (prostaglandin).

There are anecdotal reports of neem being an anti-histamine.
http://stason.org/articles/wellbeing/health/The-Miraculous-Neem.html
An Indian friend said Neem was known to be an anti-histamine in clinics there but I can't find any papers researching this property of it.

How are methionine, neem, SAMe, pharmaceutical anti-histamines, calcium channel blockers and neurosteroids like testosterone and progesterone related? One good answer is histamine.

[Prancer]

Grrr, that histamine (more like histaMEAN) is causing so much trouble for us!

And heat releases histamine, so maybe that's why some (including me) of us get POIS symptoms from a hot shower (as opposed to a tepid shower).

[nathan123]

Hi,  I would like to tell one thing.  My body is producing excessive heat and most of the times my testicles is loose. 

Whether this excess heat of the body is cause for excess histamine?

[kurtosis]

Hi,  I would like to tell one thing.  My body is producing excessive heat and most of the times my testicles is loose. 

Whether this excess heat of the body is cause for excess histamine?

Sounds possible. How showers cause histamine release but a longer hot bath can be a really good way to release the histamine and flush it out of your system. Try it, that's one of the reasons people find hot baths relaxing. Particularly those with stressful jobs.

I've found vitamin C capsules are good also but they often make me feel a little hot and dizzy when I first take them and then gradually my sinuses clear and I feel better.

[acronym]

nathan123
That is wonderful news for you that Flunarizine hydrochloride is working well for you. With your doctor, did you describe migraines as one of your main symptoms? I don't get migraines at all. I do get pressure headaches but it is only during the warmer more humid months of the year, otherwise I get brain fog all year around. I did not find much info on Flunarizine hydrochloride and post coital headache on the www. 
Are you experiencing any side effects since taking it?

nathan, as regards your point C. Neem has anti-parasite + anti-bacterial properties I thought. The fact that you feel better skipping meals can also fit in with this. I get the same effect, eating less I handle pois/cfs better, skipping the evening meal and I have a more refreshing night's sleep. Many CFS sufferers report the same. I have had a few bowel/fecal pathology tests and showed up with parasites + numerous bad bacterial overgrowths. I am have had a number of treatments over the past 4 yrs and my pois symptoms are not as severe, but I still have them. I am going to do a follow up path test in a few weeks to see how things are. I am not saying this is the cause of pois, but maybe a contributing factor for some of us that puts extra load on the liver or absorption of nutrients or creation ofneurotransmitters, IDK.