[Vincent M]

LAPOISSE, if you do try mucuna pruriens be careful with it especially if you have any heart conditions. I've been taking 350mg capsules and it seems if I take one a day for about 4 days I'll get a faster stronger heartbeat that begins about a week later and lasts for another week. A safer option is probably to take tyrosine, which your body then converts to levodopa as this will prevent levodopa overdose.

[poised]

I have constant POIS, it just gets worse after O.
From my observations, I have an idea that the cause of POIS is some autoimmune or allergic reaction. I have noticed  that for me the more semen contacts penis during ejaculation, the more severe POIS gets after.
Any ideas whether it is possible that an allergy/autoimmune could cause POIS for me to be constant? Or an allergy should disappear after some time?

[urano75]

I have constant POIS, it just gets worse after O.
From my observations, I have an idea that the cause of POIS is some autoimmune or allergic reaction. I have noticed  that for me the more semen contacts penis during ejaculation, the more severe POIS gets after.
Any ideas whether it is possible that an allergy/autoimmune could cause POIS for me to be constant? Or an allergy should disappear after some time?

Actually each time I read "costant POIS" I think it's a contradiction in terms. As a long time sufferer of Chronic Fatigue/depression/hypothyroidism/adrenal fatigue/recurring infections and related conditions, I know what it means being constantly sick. In cases like mine sex only makes worse already existing conditions and lets events precipitate.
Unless one normally feels great, and suddenly gets sick only after sex, to eventually fully recover, I'm reluctant to believe to semen allergy and similar. There might be cases like these, but I suspect they're not the majority. Just my two cents.

[pauliebaby61]

Its been quite a while since last visiting this site. I was wondering if any clear cut answers have come in regard to this awful, disease?
What ever became of Dr Waldingers assessment and protocol for treatment?
I did have my Dr read Dr Waldingers abstract/treatment. He was very skeptical and would not try his treatment with me, of desensitizing my allery to my own semen by frequent, small injections. Additionally, Dr Waldinger never followed up with me as he stated he would send out a questionaire.

FYI-I am a 15 yr sufferer, I currently am on injectable Testosterone, 2x a week. My T level is great, but sadly it does nothing to stop POIS after O, so i am pretty much living a celibate life. I miss O, but the horrible 2 weeks afterward are NOT worth it.
I believe in my heart this problem is an immune/nervous system disorder at its core.
Any comments would be appreciated, Thank you.

[gondal4]

i genrally am normal but severly weak after ejaculation.so no constant for me

[gondal4]

idk about others but recently my ecg revealed that my hearth has some problem too.some connection with pois.deifferrent walls sending blood at different pressure

[icefloe]

Hi,

I have  chronic Lyme disease and I think that cause my POIS.  Nature's Antibiotic (example Carlic,  Olive Leaf
Extract ) usually will help with POIS symptoms. Is there anyone tested mycoplasma fermentans what is one co-infection with Lyme. POIS-people are borne with   low immune system and after ejaculation your body is under attack by different bacterias and viruses.  When you get older then all is getting worse.

[urano75]

Hi,

I have  chronic Lyme disease and I think that cause my POIS.  Nature's Antibiotic (example Carlic,  Olive Leaf
Extract ) usually will help with POIS symptoms. Is there anyone tested mycoplasma fermentans what is one co-infection with Lyme. POIS-people are borne with   low immune system and after ejaculation your body is under attack by different bacterias and viruses.  When you get older then all is getting worse.

Welcome Icefloe.
My condition resembles to yours: weak immune system and high susceptibility to viral infections, especially after orgasm. It's been like this for years, possibly decades.
I don't think I have Lyme, but it seems I am positive to CMV (Cytomegalovirus, herpes-like virus like EBV) which likely undermines my immune system, opens the way to other bugs and keeps my adrenals low. I am working to deactivate, if not eradicate CMV.
It gets worse as you age only if the underlying issues are not addressed, which it might not be easy for people with chronic or even life-time issues because you must first become aware that you are sick, then you must know what the problems are, and finally you must find a way to solve them.
Good luck.

[kurtosis]

Interesting. There's a family of autoimmune diseases called Polyglandular Autoimmune Syndrome (PAS / PGAS) that are rare, show symptoms of multiple disorders including fungal infections, general evidence of weakened immune, hypogonadism (with low Testosterone), myaesthenia gravis causing vision disturbances, chronic fatigue etc.

I looked up my AIRE genes on 23andme and found that I had quite a few mutations in the SNP's 23andme test for. It's unclear what this means but there may be a connection between AIRE mutations and PGAS. http://en.wikipedia.org/wiki/Autoimmune_regulator

[LAPOISSE2]

LAPOISSE, if you do try mucuna pruriens be careful with it especially if you have any heart conditions. I've been taking 350mg capsules and it seems if I take one a day for about 4 days I'll get a faster stronger heartbeat that begins about a week later and lasts for another week. A safer option is probably to take tyrosine, which your body then converts to levodopa as this will prevent levodopa overdose.

Thank you Vicent M for your advice. I just received my mucuna pruriens 400mg with 15% of L-Dopa ; the daily dose is suposed to be 5 caps but I'll start with 1 just to be safe.
I did try Tyrosine but I didn't notice anyhelp apart being more tanned....The Idea with mucuna is to skip one step of the conversion ; Apparently having dopamine directly usable in the brain is much more complicated(see levodopa drugs for parkinson) but I need to try that anyway.
I also received PS 100 and krill oil.
I'm taking 100mg B6 and 1g B12 a day and I do a lot of sport ; it's been a week a so far I feel much better than usual

[Prancer]

Interesting, last night I was at a party and I ended up drinking about 5 or 6 caffeinated beverages, which made me really hyper by the way, over the span of about 4 hours. I also tried the niacin again (about 600mg). It gave me only a little bit of a flush.  About an hour later I had 3 orgasms, which normally would cause me severe pois right away. Well, because of all the caffeine I ended up staying up pretty much all night. But, oddly I felt (and still feel now) really, really good mentally. I feel like my thinking is way clearer. Not sure why this is and I don't recommend it, as lack of sleep and high caffeine are obviously unhealthy. And I surely won't do this all the time 'cause I need my sleep! But it's just kinda interesting and a very rare moment with less severe pois post multiple orgasms. Anyway just wanted to post that mainly for it to be archived here because I think it's important to post when something weird reduces symptoms so any future researcher reading through will have as much data as poss. Have a good weekend and hopefully in the near future we'll finally get our cure *fingers crossed*.

Note: I was inspired to try the niacin again from Egordon's posts in the other forum. He mentions not to give up on it and also that he is being helped a lot by desens and NSAIDs (something I want to try sometime). His posts have also rekindled my interest in the semen allergy theory.

[alphaq]

anyone else here have Sinus problems? Like a dry stuffy nose (perhaps one-sided)

[Over it]

anyone else here have Sinus problems? Like a dry stuffy nose (perhaps one-sided)

Yes, I do. Gets worse with POIS & goes away when POIS goes away. Blood in the dry mucous when pois is bad as well.

[Vincent M]

One of my nostrils always feels clogged and it shifts to the other nostril about once a day. I didn't have that problem during the month my pois seemed cured.

[kurtosis]

anyone else here have Sinus problems? Like a dry stuffy nose (perhaps one-sided)

sinusitis, both nostrils.

[Gbolduev]

Dear friends,

Just  wanted to  add some info here, you might use.  As you know I  have informed you that  POIS depends on  the work of  your glands.   All other cures  are just  cover ups and wont  solve anything.  Adrenals and thyroid  are the  issue here.   Adrenals and thyroid  regulate  your  neurotrasmitters .  The POIS ratios are  sodium potassium  ,  electric ratio ,   dopamine serotonin, and  mainly I think   acetylcholine/  gaba  ratio.   As  Daniel  mentioned   he had  symptoms alike to those of post marijuana use.  Well  that is  definetely   acetylcholine  issue then.  If you have  overactive  adrenals, you might  miss acetylcholine  since   B5 is used to support the production and in  overactive adrenals  B5 is missing.   If you have low thyroid,  then you  are low on  zinc and  that is  needed for GABA regulation.    Basically  you can try   2 -3 things,      zinc B6  for gaba problems,    B5  and choline   for acetylcholine problems.     But mainly  you need to adjust your glands.   

It is not  that easy to  regulate  your glands,  since   lets say  if you  have  overactive adrenals, you are  missing B5 ,  and POIS will be gone on B5, but   you will have anxiety  on B5 , since it will speed up your  adrenals even more.   So basically you have to  speed up your thyroid first in this case to  lower your adrenals, but it will take time.     


Vincent M,   since you mentioned that you have   crazy  sex urge,  that means that your DHT levels are insane,  and  you have low thyroid ,  and   you are missing zinc.   Zinc will  slow you down   but   will  make you stronger.   Your problem is  too much acetylcholine and  little gaba.   

Good luck guys.   POIS is not the problem to get rid of,  the problem is  to get rid of  your  initial  problem,  POIS is secondary to the  original problem.

I think  this route is used for sexual exhaustion  for  years already , and everyone knows that   HPA axis gets  affected and  many doctors   succesfully cure this thing.  POIS is exactly that.   and I dont know  why  someone researches it at all to be honest.  Dr. Richards , Dr Lin,  all  hair analysis people   like  Wilson ,  Watts,  ARL , and  gazzillion  of other people will balance you no problem. I would balance you  too, but  I dont have much time now.  I  am dealing with a few   on this forum  and you will see the results /   

[Nightingale]

Wanted to let you guys know 2 interesting things:

1) My stomach has become very bloated, gassy, and painful, and the onset of these symptoms came with much worse brain function.  I have found that ibuprophen treats BOTH all the stomach issues and the brain function issues.  I am taking prescription strength ibuprophen for now

2) After discovering that ibuprophen treats my stomach and cognitive issues, a few weeks later allergy season started and I returned to BOTH stomach and brain function problems.  So I began my antihistamine, and saw improvement in BOTH categories again.

Now with both antihistamines and ibuprophen, I am definitely higher functioning than I was pre- stomach issues.

Lastly, I have just begun taking Gastrocrom, a mast cell stabilizer to see if I can gain some benefits in terms of inflammation and immune dysfunction.  I have stayed away from methylation supplements for some time, I just can't seem to tolerate them.  Hopefully this helps

[Gbolduev]

This is the reason  why Niacin  helped some here.

http://www.worldhealth.net/news/tryptophan_niacin_protect_against_alzhei/

Niacin same as nicotin  inhibits   the destruction of  acetylcholine.  That is why  when I quite smoking I got my POIS.   
Read my previous message. I bet your POIS will be gone quickly.  As a note ,  choline and anything that  increases  acetylcholine  lowers blood pressure, so  for those  who are  low on blood pressure,  take it with B5.  For those with high  blood pressure can take it alone/

Good luck

[thereishope]

Long story short,

I am convinced that POIS causes inflammation and therefore with inflammation comes inflammation in the brain, hence the cognitive symptoms. You guys have to understand that brain inflammation affects the amygdala, which means it messes with our emotional system. This is why anti-inflammatory medication such as non-steroidical-anti-inflammatory-drugs AKA Advil or CELEBREX (for beginners) AKA NSAIDS work well. My assumption is that niacin works similar to NSAIDS. Something I noticed when I started taking niacin a few days before my O that I had last night is that when I took niacin, of course I had mild flush symptoms but I also "felt my brain more" and actually experienced a feeling of more blood flow going to my brain which is a really good sign.

At this point, I am also convinced that our disorder is identical to Celiac AKD Gluten allergy.
People with this kind of allergy undergo identical symptoms to POIS and of course the only way to prevent the reactions is by abstaining by food of wheat, barley and etc..
After researching a little more about Celiac disease, they have found that there is a type of "cytokine" named Interleukin-15 that created the inflammatory response and therefore they are currently in the process of developing a medication that would essentially block Interleukin-15 and therefore people with Celiac will no longer experience these symptoms. I stongly believe that this medication can help us too.

If you guys want to look in to this a little more these are some things you can search for:

IL-15 blockers
Interleukin 15 blocker
Celiac disease symptoms
Brain inflammation symptoms

I would be more that happy to hear your thoughts!

Good day gentlemen, stay strong

[Gbolduev]

Anything that raises cortisol fights inflammation.   As I mentioned/   What is there to develop.