[ozmoses]

Gbolduev should be banned for using abusive language in his earlier posts & posting nonsense arguments to increase his number of posts.

I agree.  People are having enough difficulties in their lives to then be harassed in a forum which should be a safe place.  Online bullies are just real life cowards. 

[Kima]

With pois I lost my job, family and yourself. Half of life lost

[stevenoc]

I would have my testicles out just to stop pois. But im too nervous about going to the doctors to ask. Pois has ruined me but I keep going.

[ozmoses]

Just got my Prolactin and Progesterone labs back and they both fall within the reference range.   This leads me to believe that Prolactin is not the key variable in POIS.  Granted, I haven't checked my dopamine/other neurotransmitter levels yet.  Was really hoping that Prolactin was the key.

MY KEY SYMPTOMS POIS AND SITUATIONS
Morning or daytime orgasms result in remainder of day exhaustion/irritability (sleep during daytime)
Flat affect
Dark Circles
Irritability/Anger
Depression
Occasional swollen abdomen
Pain in back/neck
Social Isolation
Limited to no libido
etc.

I will not have intercourse in the morning nor any other sexual activity due to these symptoms.  All sex related activities are at night, shortly before bed due to negative symptoms. 

POIS symptoms last for at least 4/5 days or are continuous if I do not abstain from orgasm.   

Possible help has come from P5P dose of 150mg (3x 50mg) and at least 100mg of zinc per day.
Waiting on Mucuna Pruriens delivery Monday. Hope that it provides some benefit.

Has anyone been tested for low dopamine and found that boosting dopamine has lessened the POIS symptoms?

Thanks everyone!  Never give up. We can figure this out!!!

[fornicationDENIED2]

I had a POIS relapse, and also other symptoms like chronic insomnia, etc.

It turns out that the opiates I took to manage the pain from tonsil removal on a 4 day period elevated my damn prolactin again. I should have known this would happen.

Newest blood test shows this: Prolactin......9.06 NG/mL range for males (<=10)

Inside the stupid range yet feeling like my world is collapsing anyway. I need to get dopamine agonist prescription, yet I am scared if 2 or 3 weeks of usage which is probably all I will ever need will cause withdrawal syndrome, there is no information about short term usage side effects regarding withdrawal that I am aware of and it drives me insane.

I also may need an excuse if my levels are not high enough for qualifying for hyperprolactemia treatment, could social anxiety be a valid excuse (This is something I actually have to some degree thanks to POIS mainly)  or any other mental condition?

Questions to you: Have you ever been on antidepressants? Have you ever tried dopaminergic supplements (maca, B vitamins, certain amino acids)? How does your current diet look like? What other lab tests do you have?

People need to post lab tests because then we might pinpoint something crucial. I'm sure OP would not mind as it would support the research us non-medical, depressed beings do.

Sorry for late reply, I got denied many blood tests because of bureaucracy like thyroid tests for example. It is also expensive to have blood tests wich sucks. No antidepressants. I used aromasin, and mega doses of vitamin b6 and vitamin E. Aromasin reduced estrogen which is a prolactin secretion stimulating agent and the other ones to directly reduce prolactin secretion, and it worked at first, but some 4 days on painkiller opiates set me back. My estrogen is now 27.11 PG/ML from range <=39PG/ML for men, so this time it is opiates fault. Opiates cause dopamine receptor downregulation but at only 4 day usage it could have only worsen a pre -existing condition.

This will seem stupid but I also developed porn (edging) addiction due to my abstinence lifestyle and social anxiety.
This is theorized to cause dopamine down-regulation and reward circuitry malfunction, possibly making the process of healing take longer than it should.
Right now I do not have POIS but rater a long refractory period between 10-24 hours and poor erections. The refractory period for a healthy male is 30 minutes or less and someone my age can masturbate 15 times a day if they wanted to. This sexual hangover causes concentration issues tough.

 I also have suffered many autoimmune issues in the past (read my older posts if you want, although there could be useless stuff there) some caused by antibiotic usage etc. My POIS triggers were Crohn's disease and Prednisone.

Note that there is still research I need to perform and one last theory I did not have faith in at first to investigate.

[fornicationDENIED2]

I had a POIS relapse, and also other symptoms like chronic insomnia, etc.

It turns out that the opiates I took to manage the pain from tonsil removal on a 4 day period elevated my damn prolactin again. I should have known this would happen.

Newest blood test shows this: Prolactin......9.06 NG/mL range for males (<=10)

Inside the stupid range yet feeling like my world is collapsing anyway. I need to get dopamine agonist prescription, yet I am scared if 2 or 3 weeks of usage which is probably all I will ever need will cause withdrawal syndrome, there is no information about short term usage side effects regarding withdrawal that I am aware of and it drives me insane.

I also may need an excuse if my levels are not high enough for qualifying for hyperprolactemia treatment, could social anxiety be a valid excuse (This is something I actually have to some degree thanks to POIS mainly)  or any other mental condition?

Questions to you: Have you ever been on antidepressants? Have you ever tried dopaminergic supplements (maca, B vitamins, certain amino acids)? How does your current diet look like? What other lab tests do you have?

People need to post lab tests because then we might pinpoint something crucial. I'm sure OP would not mind as it would support the research us non-medical, depressed beings do.

My diet is very poor because meat, eggs, soy protein, rice, gluten, most diary products cause autoimmune issues in me so I had to stop them. And yes, meat, eggs, gluten, etc. can activate auto immune responses but you need to learn about nutrition before leaving those, most people fail here.

 My nutrition is a bit complicated so I will discuss it later.

BTW are those dopamine supplements you mentioned a scam?

[Kima]

I bought just such a thing: http://www.iherb.com/Econugenics-PectaClear-Detox-Formula-180-Veggie-Caps/13653. If taken as directed on the bank of 3 pieces in the evening and in the morning, then after ejaculation pois decreases by 70%. Humor does not fall at all, there is a small block, not really thinking clearly. In general, searching in -70%. Checked twice. Why is it so I do not know. I can totally incompetent to make their conclusions that it was some zashlakovka body. All is good and I would use this method on, but confused by reference to the bank: "This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm." This is very annoying. Who has any thoughts? Maybe someone else has any cleaning agents tried?

[desperate man]

I bought just such a thing: http://www.iherb.com/Econugenics-PectaClear-Detox-Formula-180-Veggie-Caps/13653. If taken as directed on the bank of 3 pieces in the evening and in the morning, then after ejaculation pois decreases by 70%. Humor does not fall at all, there is a small block, not really thinking clearly. In general, searching in -70%. Checked twice. Why is it so I do not know. I can totally incompetent to make their conclusions that it was some zashlakovka body. All is good and I would use this method on, but confused by reference to the bank: "This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm." This is very annoying. Who has any thoughts? Maybe someone else has any cleaning agents tried?

I think a lot of us went through the "detox" phase and bought all kinds of supplements. I just received my package of vitamins, but don't have high hopes for it. I don't want to discourage you. By quitting porn and avoiding the computer you will resensitize and upregulate your dopamine receptors higher than you could without taking drugs. Lots of us here are addicted to porn, social websites and everything computer related. That's the reason some feel like superman when they abstain from porn and ejaculation for a long time (2+ weeks). Personally I have a friend I met through similar boards few years ago and he did go 8 months without porn and reported that nothing changed. I asked if he was surfing youtube and social sites, especially for women in nice dresses? He said yes.
Currently there are no supplement for us that could compare with going a long time without masturbation/sex. There are a few who healed, but the ones who recover tend to move on with their life and never report back again because this is a depressing place on the internet to be at.
I still believe in the semen allergy theory and for those who have an addicted personality quitting porn, PMO will not fix the damaged dopamine receptors. One needs to stand up from the chair, go outside and live. I believe this is something arising from our childhood. It is bad parenting and failure to teach us about our limits. I can't imagine anything more addicting than a computer other than drugs like heroine. If you let your child use the computer all the time then he/she will close up to friends and spend all the time inside since friends will not give that rush of high as the computer will. I would like to get a baseball bat and smash this PC to pieces, but the depression would be a killer and would end up buying another one. It's a pity that now I work on this computer for a living. But have spent 15 years abusing my brain with videogames and compulsive internet surfing.
Back to friends - have friends who prefer to be active and not sit at home all the time. Ditch the electronics and see results that no supplement can give you. No PC, no TV, no magazines, no nasty thoughts. Just socialize. I hate to say this, but supporting friends are key to success. It is the way our mind was designed to live for the moment and interact with people and not to sit down in fronft of the computer first thing in the morning and turn it off late in the night.

[ozmoses]

Started Mucuna Pruriens on Monday and have noticed zero benefit.  Very bummed about that.   I probably have one of the genetic mutations that have an affect on dopamine in my brain. No idea what to do, where to go to deal with this.

[desperate man]

Tried Niacin 50 mg dose and it has been 8 hours now and I'm still sweating?!? Anyone could give me some advice? It didn't help with POIS at all! It made no difference! I'm feeling really sick and my stomach is burning too.

[dsts6]

Hi all, new to the forums here, but have been aware of this thread and POIS for many years. I do not know if I would consider myself to have POIS. All I know is that I have always felt down, depressed, numb, irritable after sex/orgasm/ejaculation. This lasts for many hours up to a few days. I also believe it effects me emotionally in a subtle way for up to two weeks. Interestingly, I don't seem to have this issue from nocturnal emissions (wet-dreams).

Anyway, years ago I concluded that what I am experiencing is sort of an exaggerated refractory period, so my focus has been on limiting or eliminating the Male Refractory Period. With the guidance of a doctor (who was rather alternative) I tried a few different meds. I tried Cabergoline after having red the Kruger article, but it made virtually no difference. I played around with L-dopa which just made me unstable emotionally. I even went as far as to try some Beta blocker medication that had a side effect of preventing ejaculation. I tried it on one occasion as an experiment and needless to say it does block ejaculation, but has no effect on the Post Orgasm symptoms or refractory period. That to me made it clear that my issues at least are orgasm induced, and not caused by ejaculation itself.

Anyway, I eventually became tired of looking for solutions and started just avoiding ejaculating during sex for months at a time. Let's just say that women I have been with have not been particularly understanding about it and seemed bothered by the idea of me avoiding orgasm/ejaculation. Part of my interest in avoiding orgasm came from reading the book "Cupid's Poisoned Arrow" and it's associated websited reuniting.info. However, I must say that cutting orgasm out of my life entirely wasn't that great of an idea. I to a large degree lost interest in sex in general and even though I enjoyed the stability, it just took something away from me that I don't think I want to lose. Then the last couple years, I have just sort of ignored the problem as much as I could as thinking about it often has made me feel helpless and alone.

I am now looking to go to grad school to study something along the lines of behavioral neuroscience. I am trying to make sure I get a well rounded education that could enable me to in the future look into things like POS. I am also very interested in other psychology issues such as emotion and consciousness, so I felt Behavioral Neurosci would give me a broad enough education in order to get involved in all kinds of things later.

Anyway, I have a renewed desire to start learning more about POIS and post-orgasm issues in general.

I came across this article: newbielink:http://faculties.sbu.ac.ir/~salehi/hypothesis.pdf [nonactive]
I know you guys spoke about GnIH antagonists in around 2010. The guys who wrote the above article seem think that's the simplest way of limiting or eliminating the refractory period. I think I red comments here that suggest that it is a problematic solution. Anyone care to share their thoughts on this and clarify? This thread is long and complex so any summaries are greatly appreciated.

[desperate man]

Guys, one of the smarties here could PLEASE explain to me why I lose intelligence and creativity after orgasm? Why I feel like my IQ literally doubles if I abstain? I don't even give a damn if I will never cure, but WHAT is the reason for this? Is it just monoamine levels being unbalanced? Is it a receptor issue rather than neurotransmitter levels? Is it hormones? What is it?
I'm gonna lose my job if I can't focus. During meetings I just can't keep up with conversations. I'm highly thinking of doing drugs to be able to keep up with business partners. I've been raised not to ever do harmful drugs and can't believe this is my destiny...to go this far. Any input is appreciated!

[dopamine]

Hi everybody, happy to know I am not the only one.
800 pages of posts are really a lot to read, so I go for my easy question: have enyone tryed boostind the dopamine levels? I am going to try starting today and will let you know the results. Why dopamine? After ejaculation when dopamine is low, prolactin is high.  Prolactin is what make us feel tired after sex, but should stay high only for a short period of time until dopamine kicks back in. If dopamine stays low because of dopamine deficency, prolactin stays high for a long time and make us feel unconfortable. Crazy theory made by me last night. Time to test it.

[Dean93]

Hey guys. How is everyone doing? I haven't been here in a while, would anyone like to catch me up on recent news?

Anyway, I'm doing an AMA, which is basically on online question and answer session, about POIS on a site called reddit. I'm making this post as proof, but feel free to check in and participate. Link is here:

http://www.reddit.com/r/IAmA/comments/2gkkdg/iama_guy_with_post_orgasmic_illness_syndrome_ama/

[desperate man]

Not so long ago I was joking with becoming a Buddhist Monk, if the remaining supp in my repertoire fails to change this state of mind. It was Carnitine. I tried both ALCAR and Carnitine fumarate. Like always, it had placebo effects on me. I didn't wanted to give up so I decided to completely eliminate porn from my life and go on a 30 days abstaining without touching myself, without youtube fetish videos, without girls in swimsuit on social sites etc.

This is my 5th day and I feel fantastic! I have been credited for my recent work by highly respected colleagues. The cloud of depression is shifting, and I actually did pushups and dips for the first time this year. The irrational thinking is gone and no longer have to rely on benzos to sleep. Sleep is still messed up. I got no erections at all (which helps me achieve my goal of 30+ days). I've got that "drive" in life and want to do and learn new things without the brainfog. Adrenals are pretty messed up. Severe fatigue and brainfog at daytime, but superhero at night with a sharp brain. Literally doing so much work in under 3 hours that used to take me 5 days to complete. I'm hoping to fix my sleep cycle to maximize these benefits. I'm looking forward to grow full beard and get results in the gym for the first time in my life. No other supplement or diet made me feel this awesome. Not even close. This is what we need to seek - this feeling of awesomeness & well-being.  [O8)]

[desperate man]

Yesterday I started to have erections first time in 5 days of abstaining and I noticed an immediate decline in intelligence and creativity. This remained today as well. No porn were involved. It sounds like some kind of brain-, neuroinflammation. Like PTSD? I thought about sex and shortly after I had the cloud of depression remain that's now 24+ hours. Could the porn use in childhood create such PTSD that the sexual imaginations lead to the effects like picturing blood, murder and horror? Maybe that's why I get depressed? The possibilities are so endless we will never find a cure.  [V]

[Fight POIS]

Hi guys,
I am very glad about having found this forum a few weeks before, because until then i was sure to be the only one suffering from POIS. I would like to invite german speaking people concerned to the forum I founded today: newbielink:http://pois.forumieren.com/ [nonactive]
Best wishes!!!
Fight POIS

[Bulbo]

hello everyone.
    has anyone tried resveratrol ? One member has very good results with resveratrol. i have not tried it. i am going to try it . tomorrow i may buy it. in the past in this forum some users reported success with blueberry juices, etc. blueberry juice contains resveratrol. i think it is worth to try resveratrol.

[desperate man]

Just read about acetylcholine and dopamine. Thought that it should help increase dopamine all along, but they seem to have an inverse relationship. I think we can all agree on that the best neurochemical issue that matches ALL of our symptoms is elevated acetylcholine. This has been mentioned on POIS boards a few hundred times. Has anyone had success with lowering ACh? What natural methods are used for lowering it and what is the cause behind it?

[acronym]

hello everyone.
    has anyone tried resveratrol ? One member has very good results with resveratrol. i have not tried it. i am going to try it . tomorrow i may buy it. in the past in this forum some users reported success with blueberry juices, etc. blueberry juice contains resveratrol. i think it is worth to try resveratrol.

I am trying resveratrol now. 200mg / day. Its too early to report anything as I've only been on it less than a week, but so far this week has been pretty good for me, but then I have recently started a few other supps too like Mucuna Dopa and Sulbutiamine. Last year I took the herb Japanese Knotweed and my pois was  improved over that period, but I was still feeling pretty lousy. What is complicating things for me is that I have been diagnosed with Lyme disease. I was taking the Japanese Knotweed for this. it is very high in resveratrol. It sis supposed to be improve blood flow and be anti-microbial and anti-inflammatory. I am trialling resveratrol for the moment to see if I still get the same effect for less $.

I had reported in a past post that blue berries had helped to alleviate the impact of pois somewhat for me. They were no cure by any means but just helped with cognition + libidio bounce back + energy. For many years the effect seemed to have disappeared but when I switch to organic blueberries a few years back I noticed feeling better after eating them again, but not to the extent I did when I was younger. The brand of Japanese Knotweed tincture I used was from beneficialbotanicals, if you feel the resveratrol is helping a little and want to see if maybe JK might be better still.