[Bulbo]

Congratulation and thanks to give your progress 1 year later.
Do you have hormones bloodtest ?
If it is slow, it might be the balance of hormones.

Hello B_Jim
I didnt do a hormone blood test..... I will do it soon

[B_Jim]

r

Congratulations for your succes.
It proves once again that Pois has an inflammatory/histaminic component.
It could be good to know why benardyl works better than claritine.
I had a bad experience with claritine and I'm not motivated to try benadryl

[desperate man]

I just finished a two week of absistance. My life has been going in a good direction. I gave up porn over a month ago and don't even miss it. I know that this evil addiction has passed because, what gives, you face naughty pictures on the internet once in a while even if you don't want to and it doesn't trigger anything in me anymore. I just acknowledge it, and move on. I beat the devil..... BUT I did felt the need to ejaculate today to my own fantasies.

There is this guy on the other board called Sameer. He's been dealing with the same sh1t I am; that is elevated blood sugar levels. My sugars have been fine the past week, as normal as a healthy human beings, sometimes a bit elevated in between meals. I had to make adjustment and reduce my insulin dosages thanks to my healthier lifestyle. It gets a bit higher from doing weight lifting thanks to the adrenaline, but it passes within 20 minutes after the exercise is complete.

So today I just MB-d. I checked my sugar few minutes later and even an hour later. It was over 400......

For the past year I just put down POIS to being psychological and my health issues to living an inactive life. But after today I just feel suicidal. I want to kill myself. I don't know what's going on. I tried reaching out to Sameer but he disappeared. When you work so hard to make such changes in your life for better health and to be a better husband, and POIS comes and slaps you in the face just to fall back to that bottomless pit you started from. Should I just give up? Should I just kill myself? Anti-histamines would do jack sh1t about hyperglycemia, but I'm relieved to know that others have success with it. I've had POIS for the past 8 years before and after diabetes diagnosis. I want my life back so bad I could kill somebody to get it back. This is a nightmare you cannot wake up from!!!!!!!!!!!

2 hours after I ejaculated I have the following symptoms: severe toothache (wasn't there before), migraine going through left eye (wasn't there), depression (wasn't there), acetone breath (wasn't there), anger (wasn't there), feeling cold (wasn't there), cannot focus/concentrate (wasn't there), feeling dumb (wasn't there).

[acronym]

Hello everyone
     I am very happy to tell you guys how well eggs are helping me against POIS. I started eating eggs after reading Gcrisp post in the naked scientists forum.

I would be curious to know if it was the egg whites or the yolks that were helping you. I have an allergy to eggs so it is not a viable option especially every day. Through experimenting I found it was the whites that were worse for me than the yolks.

Have you ever experimented with supplements of the nutrients that eggs are high in....like biotin, Chloline, B12, etc?

[acronym]

....So, to recap, one Claritin and one Zyrtec daily, and exactly 2 benadryls immediately, within 20 seconds or so following orgasm.  NO POIS.  Thanks to the people on this site that gave me so much information about POIS.  I would have never known what it was except for this site.  Like I said, moderators, feel free to contact me.  Thanks to all.

Happy2 I assume you are in the USA. Benadryl is not compounded the same in all countries, so people reading this should be made aware of this. In Nth America it contains Diphenhydramine (key active ingredient) but not in UK or AUS/NZ or some other countries maybe as well.

Do you have any other issues with histamine, like say feeling bad after wine or food allergies or hay fever?  There is a supplement out called DAOsin (contains Diamine Oxidase) which is for histamine intolerance. I have not tired it yet. I avoid foods I am intolerant too and my hayfever is not so bad anymore and a Zyrtec takes care of the few bad days. It is not cheap unfortunately, but this may be an option for some of us.

For me taking Zyrtec or Claratin never remedied POIS, but helped slightly with brain fog. I never experimented with 2 or 3 tabs at a time though. First generation anti histamines would knock me out with sleepiness, but I probably never tried something that had Diphenhydramine in it.

[happy2]

acronym,
I have no known food allergies.  The benadryl does have a hangover effect though day 1.  I can live with that though!  Brain fog, and all the rest of the pois symptoms kicked my butt.  I would encourage anyone to give it try.  2 benadryls within 20 seconds or so of O, and Claritin and Zyrtec daily.  I hope it helps somebody.  Thanks.

[Jake81]

I was wondering if anyone else has selective IgA deficiency, which is an immune dificiency disorder.  I've been doing a lot of blood work recently and I found this out when testing for allergies (Celiac disease in particular).  IgA is a blood protein that provents agains infection of the respiratory system and digestive tract.

[happy2]

I cut out the Claritin a week ago.  Continued the Zyrtec nightly during that time period.  Last night nocturnal emission, popped 2 benadryls and it still worked.  Next morning, total clarity, just the effects of the benadryl to deal with.  So, still works, even without the Claritin.

[meteo74]

I cut out the Claritin a week ago.  Continued the Zyrtec nightly during that time period.  Last night nocturnal emission, popped 2 benadryls and it still worked.  Next morning, total clarity, just the effects of the benadryl to deal with.  So, still works, even without the Claritin.

Hi    happy2

would you make some brief to me or your advise about what to take,shall i take the    
medicine before,after,or when i am in pois..?how long i must use this medicine?
regards..

[happy2]

Meteo74,
This is a reply I sent to one of the senior members of this forum just 10 minutes ago.  I don't know if it went through to him or not, so I will post it again here. 
The treatment is one Zyrtec every day.  And 2 benadryls within 20 seconds immediately following orgasm.  That's exactly 2 benadryls after each orgasm.  My urologist said anti-histamines are not a problem for the liver.  He said the only side-effect of multiple anti-histamines taken in a single day is that it "will just dry you out".  He recommended taking one Zyrtec every day.  So, to recap, the one Zyrtec every day and 2 benadryls immediately within 20 seconds after each orgasm.  I have used this treatment of 2 benadryls multiple times per day and it works every single time.  The only effect is that it puts me in a bad mood the following day with the benadryl hangover.  So to avoid that, I try to keep it to only one O on any given day of the week.  Hope that works.  Have a great day, any more questions, just fire away.

[Starsky]

Hi Happy2,

Have you ever tried Hydroxizinum instead of Benadryl?

Read this: Protection against endotoxin shock by antihistamines and similar pharmacologic agents has been reported in the literature. The authors tested the validity of this form of treatment by animal experiments which were conducted in three phases. During the first phase, 10 mice each were treated intravenously with various doses of gram negative endotoxin to determine the dose of endotoxin which would kill 80% of the animals (LD80). This dose was determined to be 36 mg/kg bodyweight. During the second phase, 10 mice each were pretreated with various doses of either diphenhydramine (Benadryl) or of hydroxyzine HCI (Atarax) one hour prior to the administration of the LD80 of endotoxin. It appeared that high doses of diphenhydramine as well as of hydroxyzine were highly fatal to most animals by causing severe convulsions within 3 to 6 hours at doses of 40 or 50 mg/kg. Doses of less than 1 mg/kg appeared to have no protective effect, while doses of 2.5 and of 5 mg/kg, given one hour prior to the LD80 of endotoxin, had some protective value. In the case of diphenhydramine, 60% of the animals survived with 5 mg/kg pretreatment. Hydroxyzine hydrochloride protected 100% of the 10 animals so treated during the initial experiment and 90% during a subsequent experiment, if given 1 hour before the endotoxin. The third phase of this experiment was designed to determine the optimal time at which hydroxyzine needs to be given to protect against fatal endotoxin shock. Given 6 hours before endotoxin, hydroxyzine appeared to protect half of the animals, 1 hour prior to endotoxin, 5 mg/kg of hydroxyzine protected 90% of animals; if given simultaneously, it protected all animals. When hydroxyzine was given 1 hour after endotoxin there was a 70% survival and, if given 3 hours after endotoxin, a 40% survival.

[CertainlyPOIS]

Meteo74,
This is a reply I sent to one of the senior members of this forum just 10 minutes ago.  I don't know if it went through to him or not, so I will post it again here. 
The treatment is one Zyrtec every day.  And 2 benadryls within 20 seconds immediately following orgasm.  That's exactly 2 benadryls after each orgasm.  My urologist said anti-histamines are not a problem for the liver.  He said the only side-effect of multiple anti-histamines taken in a single day is that it "will just dry you out".  He recommended taking one Zyrtec every day.  So, to recap, the one Zyrtec every day and 2 benadryls immediately within 20 seconds after each orgasm.  I have used this treatment of 2 benadryls multiple times per day and it works every single time.  The only effect is that it puts me in a bad mood the following day with the benadryl hangover.  So to avoid that, I try to keep it to only one O on any given day of the week.  Hope that works.  Have a great day, any more questions, just fire away.

I believe there is something to this.
I used zyrtec  once daily for about a week and the half before orgasms. Before the  orgasms I used my daily zyrtec about an hour before and 2 benadryls (about five to ten mins)  before.  I orgasmed back to back and then used another two benadryls right after the second orgasm.  I went to sleep and woke up the next day without that horrible fatigue, no feeling that life has been sucked out of me. I was surprised at this so I tried it again the next day following the same routine, the results were the same, no crazy fatigue.   
 
I don't think this is a fluke or placebo, four orgasms in two days, usually destroys me for weeks.

I could not see how it affects my cognitive symptoms.  I don't seem to recover 100% percent cognitively anymore no matter how long I go in between orgasms. Maybe if I use zyrtec for much longer I will see beneficial results cognitively.
I will come back to zyrtec and Benadryl  in the future I want to test other medicines/supplements.

I will warn zyrtec made me extremely sleepy, I will be careful using it and plan to go to bed much earlier than  you normally do. If you start using it, start on day you know you don't have to wake up early the next day.

[happy2]

CertainlyPOIS,
That's great!!!  I never used Benadryl before orgasm.  However, I found out if I don't take exactly 2 benadryls immediately following orgasm I get brain fog, without the fatigue.  Even if I only take the second Benadryl 3 minutes late, I'll get brain fog for 1 day following.  So if you're up for it, try taking the 2 benadryls immediately following Each orgasm.  Congratulations on the success. 

[Vincent M]

I cut out the Claritin a week ago.  Continued the Zyrtec nightly during that time period.  Last night nocturnal emission, popped 2 benadryls and it still worked.  Next morning, total clarity, just the effects of the benadryl to deal with.  So, still works, even without the Claritin.

I'm curious if you always take your antihistamines at bedtime before you go to sleep. Back when I used to use diphenhydramine(benadryl) or loratadine(claritin) for my POIS I would always dose before sleep and eventually I suspected that the primary way it was treating my POIS was by improving my sleep quality or just increasing the number of hours of sleep I got as sleepiness is an effect of those drugs.

[Bulbo]

Hello everyone
     I am very happy to tell you guys how well eggs are helping me against POIS. I started eating eggs after reading Gcrisp post in the naked scientists forum.

I would be curious to know if it was the egg whites or the yolks that were helping you. I have an allergy to eggs so it is not a viable option especially every day. Through experimenting I found it was the whites that were worse for me than the yolks.

Have you ever experimented with supplements of the nutrients that eggs are high in....like biotin, Chloline, B12, etc?

Hi acronym
 I saw your message only today... I eat the whole egg.. I think POIS is due to reduced cholesterol synthesis in the body...moreover the blood brain barrier only allows negligible amounts of cholesterol to enter the brain.... So it takes a long time to see improvements
  I have not tried supplements like biotin, choline, B12. I dont get it in my country.... I have tried many prescription drugs and other supplements... But nothing helped...  Now i believe no drugs will help for POIS..I believe nutrition is the key for POIS...I have made significant progress with eggs since my last post... I will explain it soon..
   I used to eat commercial broiler chicken eggs bought from shops.. I have been eating these eggs for 15 months...now i get cold and fever once in a month... I suspect this is due to the chemicals they give to broilers for their faster growth.. So i stopped buying eggs from shops... Now i buy eggs from people who grow hens in their backyard..
   I think eggs from home grown hens are safe than eggs bought from shop.

[demografx]

<former Moderator visiting periodically>

NORD's 3rd scientific progress report on POIS (Rutgers study) due any day now!

Will post here.

All the Best,
demo

[rockytop]

Hi,

This is my first ever post.  I think this forum provides fantastic support to all of us who suffer from this cruel condition......a condition which in normal circumstances is incredibly to talk about.

I have had what I presume is POIS for 20 years.  I guess compared to many of the other sufferers on this website I have a fairly mild version of POIS but my symptoms are still severe enough to have a huge impact and limiting effect on my life.  The main symptom associated with my POIS is burning, sore and puffy eyes.......to the extent that I just can't look anyone else in the eye when I am in my POIS state.  Lesser symptoms include mild brain fog and fatigue.  The veins on my arms also become slightly distended during my POIS state.  My symptoms last for the rest of day on which I O and the following day......the day after that I am POIS free.  Even if I pass a tiny drop of semen (without any kind of arousal) when peeing I get symptoms so I guess this would suggest that my POIS is of the allergic reaction kind.  I have had short term relationships but my condition prevents them from lasting beyond a month. 

I have tried a few treatments with limited success.  These include:

Niacin - reduces symptoms by around 80-90% when O after flush.  However, for me there is an unpleasant side effect from taking niacin where I repeatedly flush (often severe rosacea-like flush accompanied by eczema) for weeks afterwards so this is not really a treatment option for me.  It could be the Niacin is mobilizing heavy metals (primarily mercury) in my cells and this is causing the rosacea.

Probiotics - I read a paper which suggested that Lactobacillus casei could help modulate auto-immune responses so I bought a probiotic supplement which contained this strain.  For around 5-6 weeks these supplements completely eliminated my POIS symptoms.  After 5-6 weeks the supplements quickly lost their efficacy.  I have tried a number of different strains since but have not come that close to replicating my initial success.

Olive Leaf/fenugreek/garlic/Mucuna/DAOsin/theanine supplements - no effect

Herman's vitamin/mineral regime - I forget the exact protocol but consisted of manganese, copper, zinc, pantothenic acid.  This protocol did have a little effect.....around 30-40% reduction in symptoms after persisting with it for a few weeks.

Gluten free diet - no effect

Alcohol seems to reduce the symptoms significantly (70-80%) but I do not really see this is a realistic treatment.  I also had all of my mercury amalgam fillings removed just over a year ago and will monitor over the next couple of years whether there is any general improvement (am only chelating very very slowly with the occasional DMSA and/or ALA capsule)   My next treatment experimentation will involve Alpha GPC supplements.

Anyway, I would be interested to hear from POISers who have the same or similar symptoms and hear about the treatments they have tried.  My initial success with probiotics suggests that optimizing gut health can be an important part of any POIS treatment.

All the best
Rockytop

[demografx]

<former Moderator visiting periodically>

Just in case you're not aware, there is also another POIS resource named:

POISCenter

[happy2]

Vincent M,
The benadryl actually winds me up, doesn't make me sleep better.  It does that with some people.  To answer your question, the 2 benadryls IMMEDIATELY following O, and Zyrtec every day, completely knock-out my POIS symptoms.  It used to be I'd get it, like real bad, for 3 1/2 days like everybody else, then crash on days 4 and 5 with fatigue.  Now, all I have to deal with is the benadryl hangover day 1.  The brain-fog, and all other symptoms, either cognitive or physical are completely GONE.  I wake up day 2 feeling completely normal; no brain-fog, joint-pain, or fatigue and most importantly, no POIS.   It's worked for me [].  I previously suffered from POIS for 20+ years.  I'm now 35 years old.  Symptoms got REALLY bad when I was 21.

[CertainlyPOIS]

Vincent M,
The benadryl actually winds me up, doesn't make me sleep better.  It does that with some people.  To answer your question, the 2 benadryls IMMEDIATELY following O, and Zyrtec every day, completely knock-out my POIS symptoms.  It used to be I'd get it, like real bad, for 3 1/2 days like everybody else, then crash on days 4 and 5 with fatigue.  Now, all I have to deal with is the benadryl hangover day 1.  The brain-fog, and all other symptoms, either cognitive or physical are completely GONE.  I wake up day 2 feeling completely normal; no brain-fog, joint-pain, or fatigue and most importantly, no POIS.   It's worked for me [].  I previously suffered from POIS for 20+ years.  I'm now 35 years old.  Symptoms got REALLY bad when I was 21.

can you post your result in poiscenter.com, i believe others should try it. The effects on my fatigue were just to profound. I would have posted there but i think the system there is having problems, it deleted my account and wont let me create another one.