[smart (OP)]

THC-mediated neurogenesis may play an essential role in adult hippocampal neurogenesis through the stimulation of 5-HT receptors.

However, the exact mecanism of serotonin regulation via THC-mediated neurogenesis is a little obscure.

My hypothesis is that increased serotonin bioavailability may reduce stress-dependent neuroendocrine hormones responses.

Lastly, the apparent nootropic and antidepressant effects of THC-mediated neurogenesis may be correlated with a net decrease in stress-related hormonal activation and increased serotonergic function.

https://www.ncbi.nlm.nih.gov/pubmed/25125239
https://www.ncbi.nlm.nih.gov/pubmed/25108244

[chris]

Cannabinoids appear to promote the survival of hippocampal neurones produced through on-going neurogenesis.

This paper may shed some light: https://www.jci.org/articles/view/25509