[smart (OP)]

The correlation between endocannabinoid signaling and memory formation is fascinating. I was thrilled to learn that long-term medical marijuana use is now associated to improved cognitive flexibility and executive function:

http://journal.frontiersin.org/article/10.3389/fphar.2016.00355/full

However, the exact role of clinical endocannabinoid deficiency in memory-related cognitive disorders is unknown. I suspect that low levels of endocannabinoid activity is correlated with impaired hippocampal synaptic plasticity.

[chris]

I am not aware of the literature on endogenous cannabinoids and memory, but real cannabis is definitely damaging to neurocircuitry:

https://www.thenakedscientists.com/articles/interviews/cannabis-rewires-brain-0

[smart (OP)]

I am not aware of the literature on endogenous cannabinoids and memory, but real cannabis is definitely damaging to neurociruitry:

Wheres the evidences? If endocannabinoid signaling really improve cognitive flexibility and executive function, I suspect endocannabinoid deficiency may impair cognitive memory skills as well.

[chris]

Wheres the evidences?

What do you think the link I attached below my post was for? Try reading it.

[smart (OP)]

What do you think the link I attached below my post was for? Try reading it.

A interview is not necessarely a strong peer-reviewed research study. Sounds like we are trying to confuse dopamine sensitivity with the effects of exogenous cannabinoids on hippocampal plasticity.

[chris]

An interview is not unnecessarily a strong peer-reviewed research study. Sounds like we are trying to confuse dopamine sensitivity with the effects of exogenous cannabinoids on hippocampal plasticity.

He's talking about the study he has done, which you could look up, if you were so-minded. Or perhaps exposure to cannabinoids has affected your motivation?

http://www.sciencedirect.com/science/article/pii/S0006322313005027

[smart (OP)]

He's talking about the study he has done, which you could look up, if you were so-minded. Or perhaps exposure to cannabinoids has affected your motivation?

I think this study is fundamentally flawed since its methodology does not indicate the duration of the experiment. Long-term cannabis use may still improve cognitive memory in a dose-dependent manner. The reduced dopamine synthesis observed in cannabis users is not indicative of long-term dopamine levels and synaptic plasticity. The correlation between blunted dopamine release and psychotic symptoms is elusive.

[chris]

For your part, I think you may have a conflict of interest to declare...

[smart (OP)]

For your part, I think you may have a conflict of interest to declare...

True, but I don't fiddle in the affairs of scientific obfuscation.