[scientizscht (OP)]

Hello!

Can we supply RNA to a patient? If not, what are the challenges?

Thanks

[chris]

The answer is yes, we can supply RNA; but the usual way to do this is via a vector that carries into a population of cells the genetic instructions to do this, and the transduced cells then act as a source of interfering RNAs:

http://www.pnas.org/content/pnas/100/4/1844.full.pdf

More recently, scientists have developed other cargo systems that can invest and protect the RNA molecules until they are taken up by target cells:

https://phys.org/news/2018-07-materials-delivery-therapeutic-messenger-rna.html

[evan_au]

This recent article talks about how a father's environment could affect their children, by RNA in extracellular vesicles controlling DNA expression in the offspring.
https://www.scientificamerican.com/article/how-dads-stresses-get-passed-along-to-offspring/