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  4. Cells, Microbes & Viruses
  5. What are molecules that kill cells by interacting with DNA?
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What are molecules that kill cells by interacting with DNA?

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Offline scientizscht (OP)

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What are molecules that kill cells by interacting with DNA?
« on: 10/11/2019 10:51:26 »
What are molecules that kill cells by interacting with DNA?

Can I have a complete list?
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Online Bored chemist

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Re: What are molecules that kill cells by interacting with DNA?
« Reply #1 on: 10/11/2019 11:04:19 »
Quote from: scientizscht on 10/11/2019 10:51:26
Can I have a complete list?
No.
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Offline scientizscht (OP)

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Re: What are molecules that kill cells by interacting with DNA?
« Reply #2 on: 11/11/2019 14:40:29 »
Quote from: Bored chemist on 10/11/2019 11:04:19
Quote from: scientizscht on 10/11/2019 10:51:26
Can I have a complete list?
No.
Doh!

Anyone else please?
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Offline chiralSPO

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Re: What are molecules that kill cells by interacting with DNA?
« Reply #3 on: 11/11/2019 15:05:44 »
Quote from: scientizscht on 10/11/2019 10:51:26
Can I have a complete list?
No.

But I'll give you a place to start: https://en.wikipedia.org/wiki/Crosslinking_of_DNA#Exogenous_agents
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Online evan_au

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Re: What are molecules that kill cells by interacting with DNA?
« Reply #4 on: 11/11/2019 22:30:56 »
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What are molecules that kill cells by interacting with DNA?
Many anti-cancer drugs work by interacting with DNA.

The challenge is to kill the rapidly-dividing cancer cells, without killing (too many) of the non-cancerous cells.
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Re: What are molecules that kill cells by interacting with DNA?
« Reply #5 on: 11/11/2019 23:42:36 »
I imagine any mutagens, in theory, can kill cells by causing excess DNA damage: https://en.wikipedia.org/wiki/Category:Mutagens

Alpha-Amanitin interferes with DNA expression and as such can be quite deadly: https://en.wikipedia.org/wiki/Alpha-Amanitin
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