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Hi @Kryptid 😊The Header(OP) & the Body do not match up.Imma a bit konfused as to wat 2 respond 2😑P.S. - Don't work so hard, take a Break!🍭
SARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope
Are COVID-19 Vaccines safe for pregnant women (& their babies)?
Everybody generates a different set of antibodies, based on their "Major Histocompatibility Complex" (MHC) genes.So you really can't compare the antibodies from two people, one who got a vaccine, and one who was infected with live virus.- It would be possible to do a partial comparison between inbred mice from the same strain, where all the mice have very similar MHC genes.See: https://en.wikipedia.org/wiki/Major_histocompatibility_complexQuote from: WikipediaSARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelopeThe sort of antibody differences you would expect to see in mice studies between a vaccine and a Wuhan strain infection would be:- The antibodies against the Spike (S) protein of the vaccine would be similar - For someone with a live SARS-COV2 infection, you would expect to also see antibodies against the E (envelope) and M (membrane) proteins. (The N protein is hidden inside, and is not so likely to provide a good immune response). - This would be similar to the response to a killed virus + adjuvent, like the Chinese vaccine.- For a vaccine like the AstraZeneca, you would expect to see some antibodies against the chimpanzee adenovirus which is a carrier for the vaccine - similarly for the virus used to carry the Russian Sputnik vaccine.- The RNA vaccines should have a more targetted immune response against just the S protein.- The advantage of antibodies targeting the S protein is that this will neutralise the virus, preventing it from locking into the ACE2 receptor, and entering a human cell.- Antibodies targeting the N, E and M proteins would be less likely to block an infection.Of course, there are more SARS-COV2 variants around now, and these variants will trigger a slightly different set of antibodies than the original Wuhan strain.
Quote from: OPAre COVID-19 Vaccines safe for pregnant women (& their babies)?There have now been many babies born to vaccinated mums, and vaccination does not seem to impact mothers or babies negatively.- It has been shown that there are SARS-COV2 antibodies in breast milk, providing protection to the babyOn the other hand, it has been found that SARS-COV2 infection is far more severe in pregnant women, perhaps because they are partially immune-suppressed when pregnant. Outcomes are far worse for both mother and baby.So if you are thinking of getting pregnant, or already pregnant - get vaccinated!
Have there been any studies on any differences between naturally occurring antibodies from infection and the antibodies generated by the mRNA shot?
Surely the best response is to simply make an inactived vaccine with all the current variants present? Might take a bit more time to inactivate the new strains and add them but surely is a better solution.