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Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.
I asked my psychiatrist today what she thought of the fact that Asian populations have seemingly enormous writing and discussion and symptom-description on "POIS" compared to us here in the West. She thinks that Asian populations just might be more genetically susceptible to POIS. Makes sense to me: there are illnesses that are disproportionately found in other populations; African-American, Ashkenazi Jewish, etc.Perhaps we here would do well to find out what mainstream Asian medicine (not the naturopathic, "chi" alternative therapies which have not shown us much) has to say about POIS!Anyone have a thought about that?
Quote from: Paulrx on 02/10/2009 17:19:38Hello guys,I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.I truly believe that this is the way to go to combat this awful POIS!Paulyeah i can do that but it doesnt work for me, as i've stated before whatever causes the "feel good" sensation, with or without ejac, causes my POIS
Hello guys,I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.I truly believe that this is the way to go to combat this awful POIS!Paul
hii'm new herei'm so happy to join youi'm from belgium 27y male (sorry my english isn't so good)yes, i 'm a Pois sufferer, it caused me many probleme in my life (separation,depression,weaknes....)this syndrome destroyed me life, i live alone no girlfriend no wife no masturbation ...Symptoms:1)normal sexual life with woman "orgasme" every day or 4 at 5 time per week-Strong fatigue-Low mental energy-very low motivation-big anxiety and social phobia-headache-feeling little hot-many Muscular cramp...i can't stretch-lose my haire-backache -prostate ache when i piss- kidney ache-my skin pricks me everywhere and any time -probleme with my eyes i cant open its morning i must use my hand-nightmare-big brain fog non stop 24/24 7/7 -my hand and my body shake like a mini "parkinson syndrome"-palpitation-weak blood pressure-ache in testicles-no erection after orgasme -premature ejaculation-I feel hungry all the time-probleme digestivea "gas"-articulation probleme "knee"...2-- alone abstinence 1 week -nightmare still 2 day after orgasme-I feel hungry 1day-palpitation 1day-Strong fatigue 3day-very low motivation 3day-my skin pricks me everywhere and anytime 4day-big brain fog non stop 24/24 6day -feeling little hot 1 day-headache 4 day3-- alone abstinence 2 weeks -nightmare still 1 day after orgasme-I feel hungry 1day-palpitation 1day-Strong fatigue 1day-very low motivation 2day-my skin pricks me everywhere and any time 2day-big brain fog non stop 24/24 2day 3-- alone abstinence3 weeks -nightmare still 1 day after orgasme-I feel hungry 1day-palpitation 1day-not Strong fatigue-low motivation -not big brain fog non stop 24/24 1day 4--never tried 4 weeks abstinencesolutioni never found a solution of my problemebut i do sport for increase level dopamine an testosterone café and salt for more blood presurei will begin two treatments next week "Phosphatidylserine" and "Magnesium chloride"I hope it will works for me. Thank you
Paulrx, your ideas are very interesting. Was it just the post-ejac solo-neurochemical-manifestation or something else that brought you to the prolactin theory? Your idea caught my attention because I panicked for months about my sky-high prolactin (10X reference range) and found myself to be my own doctor because no one knows anything about prolactin in men! I cured it by quitting reglan, which I found in wikipedia to often cause prolactin increase. Amazingly, none of my top physicians were aware of that. Again, male prolactin sdeems to be ignored by the medical community.Do you think an (f)MRI at orgasm could reveal an abnormally high prolactin spike? Or maybe we just need to do a routine hormonal lab test immediately after orgasm to tell the story. Then perhaps we can do a comparison of those results with a non-POIS "normal" individual also at orgasm. Statistical reliability would of course require more than just 2 individuals.
Regulating prolactin secretionDopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. [12] Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin. Prolactin also seems to inhibit dopamine release, such as after orgasm, and is chiefly responsible for the refractory period.
Just ran across these articles, interesting POIS reference material from 2005 and 2006 that I haven't seen before.(1) ...(2) Another World Journal of Urology article of interest:"Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence"http://www.springerlink.com/content/1elxf861chc5p9jv/?p=ae214cf7feac435cb19b25ee60ae15c1&pi=0I'll send these to Counterpoints for possible POIS Wikipedia inclusion.
This article suggests a link between increased testosterone and increased dopamine!http://linkinghub.elsevier.com/retrieve/pii/S0361923097002116Therefore, one means by which testosterone may promote copulation is by upregulating nitric oxide synthesis in the MPOA, which in turn enhances dopamine release.Could this be why testosterone works for you, demografx?Good work with Watson Pharmaceuticals Demo, hope you can make a breakthrough!
Sorry, Martin, and thanks very much for all your help!
BACKGROUND: Androgen receptors are located throughout the brain, especially in regions involved with learning and memory. Different lengths of a CAG (glutamine) repeat polymorphism in exon 1 of the androgen receptor gene may influence androgen action, with longer repeat lengths conferring decreased androgen sensitivity. METHODS: We sought to determine if this CAG polymorphism was associated with cognition in older men. RESULTS: Among 301 community-dwelling white men (mean age, 73.0 +/- 7.1), greater CAG repeat length was associated with lower scores on three cognitive tests (p <.05 for all). In addition, 12 participants (9.8%) had cognitive impairment in the low tertile of CAG repeat length whereas 29 (16.3%) had cognitive impairment in the two higher tertiles (odds ratio = 1.8; 95% confidence interval =.9-3.7). CONCLUSIONS: Research should be directed at identifying the mechanism for this association and to determine if treatment with testosterone prevents cognitive decline.
AbstractMale sexual behavior is regulated by limbic areas like the medial preoptic nucleus (MPN), the bed nucleus of the stria terminalis (BST), the nucleus accumbens (nAcc) and the ventromedial hypothalamic nucleus (VMN). Neurons in these brain areas are rich in androgen receptors (AR) and express FOS-immunoreactivity in response to mating. In many species sexual satiation, a state of sexual behavior inhibition, is attained after multiple ejaculations. The mechanisms underlying sexual satiation are largely unknown. In this study we show that sexual activity reduces androgen receptor immunoreactivity (AR-ir) in some of the brain areas associated with the control of male sexual behavior, but not in others. Thus, one ejaculation reduced the AR-ir in the MPN and nAcc, but not in the BST and VMN. Copulation to satiation, on the other hand, reduced AR-ir in the MPN, nAcc and VMN, and not in the BST. The AR-ir reduction observed in the MPN of sexually satiated rats was drastic when compared to that of animals ejaculating once. Serum androgen levels did not vary after one ejaculation or copulation to exhaustion. These data reveal that sexual activity reduces AR in specific brain areas and suggest the possibility that such a reduction underlies the sexual inhibition that characterizes sexual satiety.
AbstractWe considered clinical observations in patients with obsessive–compulsive- and anxiety-disorders, who underwent bilateral anterior capsulotomy, as well as anatomical and pathophysiological findings. Based on these considerations, we choose the shell region of the right nucleus accumbens as target for deep brain stimulation (DBS) in a pilot-series of four patients with severe obsessive–compulsive- and anxiety-disorders. Significant reduction in severity of symptoms has been achieved in three of four patients treated. Clinical results as well as a 15-O-H2O-PET study, perfomed in one patient during stimulation, speak in favour of the following hypothesis.As a central relay-structure between amygdala, basal ganglia, mesolimbic dopaminergic areas, mediodorsal thalamus and prefrontal cortex, the accumbens nucleus seems to play a modulatory role in information flow from the amygdaloid complex to the latter areas. If disturbed, imbalanced information flow from the amygdaloid complex could yield obsessive–compulsive- and anxiety-disorders, which can be counteracted by blocking the information flow within the shell region of the accumbens nucleus by deep brain stimulation.
This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.Anybody think there may be something in this?
Quote from: hurray on 11/10/2009 01:57:12This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.Anybody think there may be something in this?I don't remember about this theory, too much data here What you say is very possible. Some people have more energy and feel better after orgasm. For me the very good orgasms can cause the worst POIS episodes. Maybe because prolactin is also increased. We had a discussion about this study : "The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety" http://www.ncbi.nlm.nih.gov/pubmed/16095799It seems possible that if POIS sufferers have an existing problem with low dopamine, even a normal secretion of prolactin will decrease dopamine enough to cause problems.
do you guys know why different labs have different ranges for the same test but also have same units for example. quest diagnotstic total testosterone250 - 1100 ngdl AEL 280 -1070 ng/dllabcorp 175-781 ng/dl it is like that for free testoterone and this is the one without bioavailable.