[demografx]

Nitric oxide

As I mentioned in an earlier post, Dr Rajfer pioneered some research into nitric oxide, which we have discussed extensively on this forum:
http://www.google.com/search?q=nitric+oxide+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&rls=com.microsoft:en-us:IE-SearchBox&ie=UTF-8&oe=UTF-8&sourceid=ie7&rlz=1I7DAUS_en

[demografx]

Letter to Dr. Rajfer's assistant:

Thank you very much for your time on the telephone Friday.
 
Would it be possible for my forum to work with Dr. Rajfer to study our very debilitating and very under-researched disorder, POIS (Postorgasmic Illness Syndrome), afflicting many millions of sufferers worldwide?
 
Our forum has gathered a significant amount of new data over the last 3 years on POIS

Our forum is at:
http://www.thenakedscientists.com/forum/index.php?topic=6576.0

Here are some POIS resources which we can provide Dr Rajfer:

A  very detailed online survey on 75 POIS sufferers.
http://pois.olympe-network.com/

Our POIS Information Website
http://sites.google.com/site/POISwebsite/

Member "B_Jim"'s POIS Summary of All Cases(300) here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our POIS chatroom (realtime chat). 
http://forums.delphiforums.com/POIS/chat

POIS 2002 Medical Research investigation (attached)
A medical investigation on POIS by Dr. Marcel Waldinger, MD and Dr. Dave Schweitzer, MD.

New York Times article,
January 20, 2009
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

We've been referenced in respectable sources such as the British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For for over 3 years, our POIS forum has attracted over 150 POIS sufferers worldwide who have posted here, plus nearly 700,000 page visits.
 
Dr Rajfer has most unique and impressive credentials that could help us enormously. I very much look forwarding to hearing back from you!
 
Sincerely,

[demo]
123.456.7890 Cellphone

[Animus]

FYI, cross-posted from another thread:

What baffled me so, 18 months ago, on the POIS board was the complete unwillingness to consider chronic masturbation as an addiction
 

You have absolutely no evidence of POIS as a chronic masturbation phenomenon.

Many sufferers are loving and happily married men and even for procreation purposes still suffer the agonizing and devastating aftereffects of POIS.

Please check your facts more carefully. Thank you.

Yup , this has nothing to do with chronic masturbation. Whoever this guy is, has clearly not a clue.

[Animus]

More:

Three years ago I gave up being orgasmic and like the POIS BOYS, it helped enormously.

Still the problem was not solved. When I stopped being sexual completely the problem disappeared.

All the pills, powders, vitamins, teas, patches, shots and therapies avoid the only important question: If you're doing something that hurts you, why don't you stop?
 

The "POIS BOYS" have also discovered that being a eunuch doesn't solve the problem either.

We are sexual beings, given nature's gift of orgasm.

Several of us have found wonderful solutions with "patches, pills, etc.", and on the verge of finding even better ones.

Not to hide a problem, but to SOLVE a neurochemical/physiological problem, i.e., hormal imbalance, neurotransmitter deficiency and the like.

I think for me also, there's a difference between Solving the problem, and Avoiding the problem.

[Animus]

laurac,
thanks for posting that interesting article link.
I understand these steroids work in synergy to block sperm production. and could potentially  help with POIS symptoms.

[demografx]

Animus, I'm glad that you understand the silliness in those cross-posts.

[Guthrie]

An update on my experience with olive leaf extract:

For the past few months, I’ve been experimenting with olive leaf extract.  I’ve been using Barlean’s Olive Leaf Complex, and my typical dosage has been to take 1 Tablespoon (15 ml) daily, in a single serving.  I have also experimented with supplementing that with additional servings in the time period surrounding an O.

I’ve found that in general, there is noticeable improvement in my POIS, particularly in the brainfog realm.  However, I’ve still often felt emotionally sensitive and irritable.  Still, it has done a good job in helping to alleviate the tortuous ‘really bad feeling’ that would otherwise accompany my POIS. 

Recently, though, I’ve started formulating a bit of a theory as to the ideal form of taking it.  I think that it may be most effective if taken a couple of hours before O.  My sense is that taking it right before O, or after O, or the next morning, may not be as effective.  That is, there may be a factor by which the olive leaf takes a little while after ingestion to become ‘active’ and helps to prevent the bad cycle from starting in its full force.  In contrast, taking it too soon before O may not allow it to become active soon enough, and taking it after O may have less of an effect once the bad cycle has already begun.

This past Friday night, I O’d, and I had taken a few servings throughout the day, all of them at least two hours before the O (I’d estimate 2 hours, 6 hours, and 12 hours before the O).  On Saturday, I felt generally pretty OK—some tiredness, but the POIS never ‘crossed the threshhold’ into its typical strength.  (There have been some times in the past few months when I O, and then for the early part of the next day the POIS seems to ‘teeter on the brink’ before hitting me.)   I’d estimate that yesterday’s experience was about a 60 to 80 percent cure.  So that’s good!

A few reflections on my experience:

When matsoda described his success with olive leaf, he said that he would put it in a water bottle so that it would be “consumed throughout the day.”  He also said that he took extra after each O.  But I wonder whether it might be the ‘throughout the day’ part that was most significant: i.e. if he was consuming it throughout the day, then it would have been entering his system at least a couple hours before his O.  Note also that he did not have a complete cure, but that the symptoms were reduced to ‘a fraction of the original condition.’  So there may be things to work out regarding not only amount of dosage, but timing of dosage—and, if it really needs to be a couple hours before O, this might be a less intuitive thing to think of right off the bat.

Also, in Limejuice’s success with the larger dose of progesterone, he also noted that he needed "to [ingest] at least 1.5 hours before activity and no longer than 12 hours before.”  So there might be a similar timing-dynamic at play there.  If he’s currently taking a smaller dosage, but everyday, then it could still have the ‘throughout the day’ effect.

Lastly, in addition to helping my POIS, the olive leaf had an immediate and wonderful effect on another problem I’d had: I had had warts on my fingers and on my toes for the two years or so, and also plantar warts on the bottom of one foot for the past 15 (!) years or so.  Immediately after starting the olive leaf, the warts on my hands and toes starting disappearing, and they’re now completely gone!  The 15-year-old plantar warts have also almost disappeared!  And, this was all from taking the olive leaf internally, without any external application.  (I’d tried external treatments before, but they didn’t work, and may even have made the warts spread.)  So, if it had that internal effect, I’m guessing that it could have been from stimulating my immune system to fight the wart virus.  It also indicates that perhaps my immune system hadn’t been strong enough to fight the warts on its own—so I wonder if this might point, indirectly, to an immune connection to POIS.  Perhaps my immune system is also not strong enough on its own to suppress the chain reaction after an O.

[I should note that for part of the time for the past few months, I was also taking grapefruit seed extract, but my sense was that the positive effects came primarily from the olive leaf extract.  I’ve also been taking vitamin D for the past year or so, but I hadn’t really noticed much of an effect from that, although it might have built up gradually.]

Anyway, that’s my update—make of it what you will!

[lauracostis]

An update on my experience with olive leaf extract:

For the past few months, I’ve been experimenting with olive leaf extract.  I’ve been using Barlean’s Olive Leaf Complex, and my typical dosage has been to take 1 Tablespoon (15 ml) daily, in a single serving.  I have also experimented with supplementing that with additional servings in the time period surrounding an O.

I’ve found that in general, there is noticeable improvement in my POIS, particularly in the brainfog realm.  However, I’ve still often felt emotionally sensitive and irritable.  Still, it has done a good job in helping to alleviate the tortuous ‘really bad feeling’ that would otherwise accompany my POIS. 

Recently, though, I’ve started formulating a bit of a theory as to the ideal form of taking it.  I think that it may be most effective if taken a couple of hours before O.  My sense is that taking it right before O, or after O, or the next morning, may not be as effective.  That is, there may be a factor by which the olive leaf takes a little while after ingestion to become ‘active’ and helps to prevent the bad cycle from starting in its full force.  In contrast, taking it too soon before O may not allow it to become active soon enough, and taking it after O may have less of an effect once the bad cycle has already begun.

This past Friday night, I O’d, and I had taken a few servings throughout the day, all of them at least two hours before the O (I’d estimate 2 hours, 6 hours, and 12 hours before the O).  On Saturday, I felt generally pretty OK—some tiredness, but the POIS never ‘crossed the threshhold’ into its typical strength.  (There have been some times in the past few months when I O, and then for the early part of the next day the POIS seems to ‘teeter on the brink’ before hitting me.)   I’d estimate that yesterday’s experience was about a 60 to 80 percent cure.  So that’s good!

A few reflections on my experience:

When matsoda described his success with olive leaf, he said that he would put it in a water bottle so that it would be “consumed throughout the day.”  He also said that he took extra after each O.  But I wonder whether it might be the ‘throughout the day’ part that was most significant: i.e. if he was consuming it throughout the day, then it would have been entering his system at least a couple hours before his O.  Note also that he did not have a complete cure, but that the symptoms were reduced to ‘a fraction of the original condition.’  So there may be things to work out regarding not only amount of dosage, but timing of dosage—and, if it really needs to be a couple hours before O, this might be a less intuitive thing to think of right off the bat.

Also, in Limejuice’s success with the larger dose of progesterone, he also noted that he needed "to [ingest] at least 1.5 hours before activity and no longer than 12 hours before.”  So there might be a similar timing-dynamic at play there.  If he’s currently taking a smaller dosage, but everyday, then it could still have the ‘throughout the day’ effect.

Lastly, in addition to helping my POIS, the olive leaf had an immediate and wonderful effect on another problem I’d had: I had had warts on my fingers and on my toes for the two years or so, and also plantar warts on the bottom of one foot for the past 15 (!) years or so.  Immediately after starting the olive leaf, the warts on my hands and toes starting disappearing, and they’re now completely gone!  The 15-year-old plantar warts have also almost disappeared!  And, this was all from taking the olive leaf internally, without any external application.  (I’d tried external treatments before, but they didn’t work, and may even have made the warts spread.)  So, if it had that internal effect, I’m guessing that it could have been from stimulating my immune system to fight the wart virus.  It also indicates that perhaps my immune system hadn’t been strong enough to fight the warts on its own—so I wonder if this might point, indirectly, to an immune connection to POIS.  Perhaps my immune system is also not strong enough on its own to suppress the chain reaction after an O.

[I should note that for part of the time for the past few months, I was also taking grapefruit seed extract, but my sense was that the positive effects came primarily from the olive leaf extract.  I’ve also been taking vitamin D for the past year or so, but I hadn’t really noticed much of an effect from that, although it might have built up gradually.]

Anyway, that’s my update—make of it what you will!

very interesting, matsoda was taking a huge dose, 15ml 3 times daily = 45mls total, and your right he mixed it with water in like a two litter bottle and sipped on it slowly through out the day. i think Barlean’s Olive Leaf Complex was the one i tried also for a couple weeks, the fresh pressed one right. i think matsoda told me his was not fresh pressed. i used 45ml daily like matsoda except i just took a tablespoon 3 times a day instead of diluting it. after a week it had killed all the bacteria in my gut and gave my horrible chronic diarrhea. i had to stop after the second week. fresh olive leaf complex may be hard on ones liver if taken for extended periods of time though.  thats amazing that it has suppressed your warts. the concentration is so potent, it tastes like battery acid so you know it going to do something.  i have started taking a compound called MONO LUARIN which has antibacterial,antiviral, and antifungal properties but doesnt have any side effects. i doubt that it is as potent as fresh pressed olive leaf complex.

[Defsync]

demografx

i have another list of researchers for you

and they are a couple of miles from me, so i'd be able to meet with em in person if you get any responses, as a test subject or liaison or w/e

http://utmc.utoledo.edu/patientguests/justforphysicians/clinicalresearch/contactus.html

they are highly regarded nationally, and "The Carnegie Foundation classified the university as "Doctoral/Research Extensive."

[demografx]

demografx

i have another list of researchers for you

and they are a couple of miles from me, so i'd be able to meet with em in person if you get any responses, as a test subject or liaison or w/e

http://utmc.utoledo.edu/patientguests/justforphysicians/clinicalresearch/contactus.html

they are highly regarded nationally, and "The Carnegie Foundation classified the university as "Doctoral/Research Extensive."

Defsync, wow, thank you so much!!

[demografx]

Guthrie, many thanks for that detailed reporting on olive leaf extract!

And Laurac, I appreciate your expanding the discussion with your experience.

[demografx]

demografx

i have another list of researchers for you

and they are a couple of miles from me, so i'd be able to meet with em in person if you get any responses, as a test subject or liaison or w/e

http://utmc.utoledo.edu/patientguests/justforphysicians/clinicalresearch/contactus.html

they are highly regarded nationally, and "The Carnegie Foundation classified the university as "Doctoral/Research Extensive."

Defsync, I just wrote to Dr. Gmerek, with essentially the same info as I sent to Dr. Rajfer:
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg313996#msg313996

Def, I'll be traveling for 3 weeks starting Tuesday, feel free to follow up with her, and I will follow up too. Let's stay in touch with each other so that we look like a team  []

Contact info:
Debra Gmerek, Ph.D.
Director and Associate Dean of Clinical Research
The University of Toledo Medical Center
Jacobson Center for Clinical & Translational Research
3000 Arlington Ave, Mailcode 1034 
Toledo, OH 43614
debra.gmerek@utoledo.edu
Phone: 419.383.6919

[horizon]

I had a CAT scan of my testicles today.

The radiographer doing the scan said there is a problem with one of the sperm ducts being too narrow on my right one (words to that effect).
I then explained how I feel fatigue after orgasm for about 3 days and wondered if there are testosterone or hormonal problems.

He said "it looks physical to me" and its something to take further with my doctor.

[demografx]

Horizon, you had me worried for a sec, I thought at first that you wrote that you had a CAT on....ohnevermind, I need some more morning coffee...

[lauracostis]

Horizon, you had me worried for a sec, I thought at first that you wrote that you had a CAT on....ohnevermind, I need some more morning coffee...

"naughty kitty !"

[Animus]

An update on my experience with olive leaf extract:

For the past few months, I’ve been experimenting with olive leaf extract.  I’ve been using Barlean’s Olive Leaf Complex, and my typical dosage has been to take 1 Tablespoon (15 ml) daily, in a single serving.  ...
Anyway, that’s my update—make of it what you will!

Guthrie,
That's valuable amazing information. I'm still learning about all our related sites. But maybe there is a way you can put the experience and remedy into the "databank". document it and create a theory for our eventual researcher.
I've never heard of this extract til now and I'm reading up on it.

[demografx]

Does the "Remedial Methods" get updated regularly, or only when there is a promising method? How does that work?

http://sites.google.com/site/poiswebsite/test-page/successful-methods

I emailed your question to the author, who is in China presently.

Strawberryman,  he wrote back: "It only gets up dated when a some one finds a method that improves symptoms."

[demografx]

I had a CAT scan of my testicles today.

Horizon, you had me worried for a sec, I thought at first that you wrote that you had a CAT on....ohnevermind, I need some more morning coffee...

"naughty kitty !"

 [] [] []

[daveman]

I had a CAT scan of my testicles today.

The radiographer doing the scan said there is a problem with one of the sperm ducts being too narrow on my right one (words to that effect).
I then explained how I feel fatigue after orgasm for about 3 days and wondered if there are testosterone or hormonal problems.

He said "it looks physical to me" and its something to take further with my doctor.

This is compatible to my situation. The vasectomy reversal left the "sperm ducts" hard (scar tissue) and restricted, although apparantly open.

[horizon]

This is compatible to my situation. The vasectomy reversal left the "sperm ducts" hard (scar tissue) and restricted, although apparantly open.

What were your options? can you get them fixed?