[Quasar]

There's something i forgot to share with you. I don't know if it's relevant or not: i remember i got very low results for FSH hormone: it was like 1.xx, and the normal values were: 1 to 12.

So, it was considered "normal" by my doctor.

But here http://emedicine.medscape.com/article/118810-overview  it states that "FSH stimulates testicular growth and enhances the production of an androgen-binding protein by the Sertoli cells, which are a component of the testicular tubule necessary for sustaining the maturing sperm cell. This androgen-binding protein causes high local concentrations of testosterone near the sperm, an essential factor in the development of normal spermatogenesis"

Is there anybody with low FSH values too?

[Starsky]

Quasar, do you have some problems with your lymph nodes? I think, even when I am out of POIS i have some feeling that with my lymph nodes something wrong is. They are some times small, then getting bigger, then smaller. I cant find a answer why is it happening so.

I wonder. I've noticed too that the lymph nodes sometimes flare up with POIS, like maybe 25% of the time. And your post made me think about it, it seems that they only flare up if the prostate seems to be more inflamed. My protate also seems to inflame sometimes, and it's about the same 25% of the time, and I'd have to say almost coincident.

I have to say that it just might be that those 25% flare-ups are all associated with heavier sessions. It always seems that when the prostate and everything down there is more inflamed, the POIS sessions are, in general, worse.

Lately my sessions have been a fair bit lighter, and almost NO swelling "down there", nor lymph nodes.

Do you mean some kind of generelized swollen/tender lymphnodes or just in one part of the body?

[Quasar]

Starsky, i don't pay much attention to my lymph nodes...i can't see them specially enlarged after Pois, with exception, maybe, to the neck ones.

[Starsky]

Do you often feel tired out of POIS? I have a problem standing up of my bed in the morning, im constantly tired :/

[jivetalk]

I was a little reluctant to post with incomplete results, but I have tried niacin (250mg) before O twice now, and it does a lot to alleviate my symptoms. For now, the 250mg seems to be enough to give me the flush. I would say that compared to nothing, it reduces my symptoms (mostly cognitive brain fog) by about 60-70%.

So far I have only tried it on its own - normally, I would take a dose of fenugreek before and after O. It will be interesting to try niacin in combination with fenugreek, and I will do this at some point, but I thought it would be more "scientific" to let niacin do its work without any assistance.

So, mark up another success for niacin! I hope it proves effective in the long-term as well as the short-term.

Congratulations Hurray!

Thanks for letting us all know about your positive results. Please do keep us posted.

JT.

[Vincent M]

While in POIS when I shave my face it bleeds quite a bit even if I shave carefully with plenty of shaving cream and a new razor, but if I go 3 or 4 days without having an orgasm I can shave without any shaving cream even and my face doesn't bleed at all.

What mechanism could possibly cause my skin to become physically weaker and easier to cut? Could an immune reaction cause this? Perhaps the immune reaction causes certain glands to become inflamed which then may cause a domino effect of hormonal imbalances and digestive inefficiency which then leads to impaired skin cell growth and repair.

Just more speculation I suppose.

In any case my niacin pills should arrive soon and I'll test them asap.

[Quasar]

Do you often feel tired out of POIS? I have a problem standing up of my bed in the morning, im constantly tired :/

It's exponential. At day 5 out of Pois i feel quite good. At day 7 i feel very good. If i stay a whole week out of Pois, then i have no energy problems, and don't become tired. I even can feel very energetic at moments.

About the standing problem, i suppose you refer to orthostatic intolerance. Yeah! I also  suffer from that, specially under Pois.

But when i'm out of Pois, my orthostatic intolerance becomes nearly cured at 100%.

Orthostatic intolerance is also related to neurotransmitters and blood vessels, just like many theories we have already discussed.

[demografx]

We should eat more chocolate to increase peripheral serotonin /tryptophan !  []

If that were true, then by now, I should be The International King Of Peripheral Serotonin/Tryptophan!!!   []

[daveman]

Quasar, do you have some problems with your lymph nodes? I think, even when I am out of POIS i have some feeling that with my lymph nodes something wrong is. They are some times small, then getting bigger, then smaller. I cant find a answer why is it happening so.

I wonder. I've noticed too that the lymph nodes sometimes flare up with POIS, like maybe 25% of the time. And your post made me think about it, it seems that they only flare up if the prostate seems to be more inflamed. My protate also seems to inflame sometimes, and it's about the same 25% of the time, and I'd have to say almost coincident.

I have to say that it just might be that those 25% flare-ups are all associated with heavier sessions. It always seems that when the prostate and everything down there is more inflamed, the POIS sessions are, in general, worse.

Lately my sessions have been a fair bit lighter, and almost NO swelling "down there", nor lymph nodes.

Do you mean some kind of generelized swollen/tender lymphnodes or just in one part of the body?

When it happens, it's semi-isolated. I've had the groin area and underarms on the same side. My bones hurt too when it happens, sort of like the "softer" outer layer of the bones are inflamed. Similar symptoms as produced by prostate, but only POIS related and only about 25% of the POIS sessions. Prostate has checked out OK (out of POIS).

[demografx]

Thankfully, my PSA readings are always fine.

[B_Daniel]

  I want to spend my money on something positive - not getting rid of something negative.  But sometimes fixing the foundation of your house is more important than painting it.  It's time to repair the foundation! 

amen!  [] very well said and eloquent! I intend to donate again to the fund in the future. b_daniel is an inspiration with his level of commitment!

Amen to the Amen!! []

I'm no inspiration!  I'm just the guy who likes to throw a whole bunch of money at my problems.  And this is one problem I'd give just about anything to make go away.

[B_Daniel]

I took Niacin 5 hrs ago and just had an O.  Not a good idea.  It lasts over 2 hrs, but not as much as 5.

[hurray]

Thank you for your encouragement, Victor and Jivetalk  []

I will definitely keep you posted with my results!

[Quasar]

I took Niacin 5 hrs ago and just had an O.  Not a good idea.  It lasts over 2 hrs, but not as much as 5.

Good to know!!

[demografx]

It seems niacin is a key factor of production of insuline, neurotransmitters and sexual hormones. Very interesting.

B_Jim, do you think there is ANY connection between what testosterone does and what niacin does?

[horizon]

Pinhole glasses are good for POIS.

[demografx]

Horizon, can you please elaborate on that?

[BMX]

Hi, I'm new here, I read articles and want to show:

First, I think that brain fog, and lots other symptoms related here could be part of a depression episode (see the diagnosis in (1))

After ejaculation, we have a rise in cortisol levels (2). Studies show conection in cortisol and symptoms like depression (3) and weakness (4)

I also found articles that don't support the idea of the decrease of cognition with high corsisol levels [5], but I really thing that cortisol excess could explain the weakness and symtoms related to depression(mental fatigue, mental fog)considering other studies (6) .

I also think about treating symptons os POIS, like the depression, has anyone tried antidepressives? About the weakness, there's people that uses glutamine and vit C to treat asthenia (muscle weakness) (they decrease the efecct of cortisol in the muscles), has anyone already tried this?

Finally, I read here people using tryptopham, supporting the idea of depression. At last, there is nutrition plans to reduce cortisol levels, there is a lot of aliments that reduces cortisol levels, like vit C.

Sorry about possible bad english, that's not my first language

references:
1-  newbielink:http://www.webmd.com/depression/guide/depression-diagnosis [nonactive]
2-  newbielink:http://www.ncbi.nlm.nih.gov/pubmed/20022362 [nonactive]
3-  newbielink:http://www.sciencedirect.com/science/article/pii/S0306453005000831 [nonactive]
4-  newbielink:http://www.ncbi.nlm.nih.gov/pubmed/192172 [nonactive]
5-  newbielink:http://www.pnas.org/content/108/14/5801.short [nonactive]
6-  newbielink:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894868/ [nonactive]

[BMX]

Me again, I didn't read all the posts, there is a lot!!!

But anyone read this: newbielink:http://topnews.us/content/232830-probable-treatment-pois-might-be-out-soon [nonactive] Waldinger's allergic hypothesis. That go against the cortisol hypothesis.

But, if it's allergic, the same cortisol is anti-allergic (1) and might reduce the signs of POIS! Well, people with asthma (and other inflamatory disorders) use some drugs that contains cortisol-like molecules, if they have POIS and worse symptoms of POIS, there is support the cortisol hyphotesis, if they have decrease in the symptons, there is support the allergic hypothesis.

references:
(1) newbielink:http://www.sciencedirect.com/science/article/pii/016561479390184L [nonactive]

[demografx]

BMX, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:

Our new POIS Forum - architectural genius: "daveman" - for detailed subject-by-subject discussion!
http://www.POISCenter.com/forums/index.php
Our 4-year-old POIS thread here at Naked Science Forum will also always remain open for newcomers, for general unstructured discussion, and historical research of the 10,000+ postings here since 2007.

The Learning Channel's (TLC)  feature TV presentation on POIS, featuring our member here at this forum, "Animus". It was aired on May 22, 2011. Here is a link to the file for that TV documentary, "Desperate Measures", which can be downloaded and played. The segment starts at about 12:20..
http://www.fileserve.com/file/cUtJa9R/TITLE01.mp4

Our POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

The POIS Information Website is home to the famous POIS Forum Compendium, written by "Pyropeach", and contains theories already discussed here and treatments that have both worked and failed.

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat


POIS Research Studies, 2011

These 2 papers reveal Dr. Waldinger's POIS autoimmune hypothesis and suggests one possible avenue of treatment.

First POIS Research Study, 2002

We have a copy of the first formal medical investigation on POIS by Prof. dr. Marcel D. Waldinger,MD,PhD, and Dr. Dave Schweitzer, MD.

  
Recent POIS Research Study, 2010

CASE REPORT
Postorgasm Illness Syndrome - A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg316781#msg316781


British Medical Journal Case Report, 2010

Case study by Dr. Selwyn Dexter of a patient with a headache-featured POIS symptom treated with progesterone/norethisterone.
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short?rss=1


How to get any or all of the above 5 studies: send me or "daveman" a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and we'll send you back the PDF(s).

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around the recipient's name, i.e., "demografx", or "daveman".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the Journal of Sexual Medicine (Dr. Waldinger's study), British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For over 4 years, our POIS forum has attracted over 200 POIS sufferers worldwide who have posted here, research on an additional 200 sufferers elsewhere on the internet, plus over 1,300,000 page visits. Not bad for a rare malady!



SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: more than 4 years' worth of posts (over  10,000 posts!) from 200+ Forum members, and an additional 200 POIS sufferers found elsewhere on the Internet by Member B_Jim.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://thenakedscientists.com/

for example, I tried
nocturnal emission POIS site:http://thenakedscientists.com/

and 740 results came up for "nocturnal emission" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.