Gene of the Month - Sarcolamban

Our gene of the month may be small, but it's surprisingly important.
10 May 2015

Interview with 

Kat Arney


And finally, it's our Gene of the Month, and this time it's Sarcolamban. A relatively new addition to the list of fruit fly genes, Sarcolamban gets a mention because of its unusual size - it's much, much smaller than regular genes, and one of thousands of so-called smORFs, or small open reading frames, scattered throughout the genomes of many organisms. For a long time it was unknown exactly what - if anything - these smORFs do, but the tiny proteins that they encode are now being discovered to play all kinds of important roles in cells.

Sarcolamban itself makes two little proteins, known as peptides, that are important for keeping flies tiny hearts beating regularly, and a similar gene has been found in humans. So, as with so many things in life, size doesn't always matter.


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