Gene drive to wipe out mosquitoes

Scientists have successfully eliminated a group of mosquitoes in the lab, by editing their genes...
04 October 2018
Presented by Chris Smith
Production by Katie Haylor.


Mosquitoes spread diseases like malaria, and they are rapidly becoming resistant to the insecticides used to control them. So scientists are looking at the potential of using a genetic technique, called a gene drive, to solve the problem. This involves engineering a gene-editing system into the insects that targets and inactivates a gene called dbx - or doublesex - that is needed for the insects to develop normally. Critically though, only female mosquitoes, which are also the ones that bite, are affected by the change. This means that males are left unaffected and can spread the genetic modification through the population; but affected female mosquitoes are unable to reproduce, and within 8 generations, the population crashes to zero. Chris Smith heard how it works from Imperial College's Andrea Crisanti...



Reference: A crisPr–cas9 gene drive targeting doublesexcauses complete population suppression in caged Anopheles gambiae mosquitoes


I'm not keen on mosquitoes, but I don't think the food chain should be this altered with. Mosquitoes play their part. I know species will adapt, but some will flourish and others will suffer. Terrible domino effect, for a radical idea.

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