Dogfish steroid suppresses Parkinson's Disease

A chemical found in dogfish sharks blocks a protein from accumulating and damaging brain nerve cell membranes.
24 January 2017
Presented by Chris Smith
Production by Tom O'Hanlon.


Spiny dogfish (Squalus acanthias)


A chemical found in dogfish sharks blocks the process that leads to Parkinson's Disease, scientists at Cambridge University have found. The steroid squalamine prevents a protein called alpha-synuclein from accumulating on and damaging nerve cell membranes in the brain. A synthetic form of squalamine protected cells cultured in a dish and also protected microscopic worms that were genetically altered to develop a Parkinson's-like syndrome. Chris Dobson explains how he and his colleagues made the discovery...


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